Nasal Bioadhesive Drug Delivery Systems and Their Applications

Badhe, Ravindra V.; Nipate, Sonali S.

doi:10.1002/9781119640240.ch10

Cited by 11 publications

(6 citation statements)

References 175 publications

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“… 208 In addition, stimuli-responsive polymeric NPs could be designed for controlled delivery of antigens 209 and development of nasal bioadhesive vaccines. 210 Furthermore, cationic polymeric NPs help in the formulation of nucleic acid-based vaccines; 157 , 211 , 212 however, adverse effects including inflammatory responses, toxicity, and clearance by macrophages in the mononuclear phagocytic system (MPS) are reported. 213 , 214 Regarding the demand for immunization against coronaviruses, some attempts on polymer NP vaccine preparations have been reported.…”

Section: Nanoparticles For Anti-coronavirus Therapeuticsmentioning

confidence: 99%

“…These NPs could encapsulate antigens to protect their structure against degradation and also provide controlled-release systems for a prolonged antigen presentation. , Some polymeric NPs serve as adjuvants to enhance the immunity responses . In addition, stimuli-responsive polymeric NPs could be designed for controlled delivery of antigens and development of nasal bioadhesive vaccines . Furthermore, cationic polymeric NPs help in the formulation of nucleic acid-based vaccines; ,, however, adverse effects including inflammatory responses, toxicity, and clearance by macrophages in the mononuclear phagocytic system (MPS) are reported. , Regarding the demand for immunization against coronaviruses, some attempts on polymer NP vaccine preparations have been reported.…”

Section: Nanoparticles For Anti-coronavirus Therapeuticsmentioning

confidence: 99%

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State-of-the-Art of Nanodiagnostics and Nanotherapeutics against SARS-CoV-2

Derakhshan

Amani

Faridi‐Majidi

2021

ACS Appl. Mater. Interfaces

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The pandemic outbreak of SARS-CoV-2, with millions of infected patients worldwide, has severely challenged all aspects of public health. In this regard, early and rapid detection of infected cases and providing effective therapeutics against the virus are in urgent demand. Along with conventional clinical protocols, nanomaterial-based diagnostics and therapeutics hold a great potential against coronavirus disease 2019 (COVID-19). Indeed, nanoparticles with their outstanding characteristics would render additional advantages to the current approaches for rapid and accurate diagnosis and also developing prophylactic vaccines or antiviral therapeutics. In this review, besides presenting an overview of the coronaviruses and SARS-CoV-2, we discuss the introduced nanomaterial-based detection assays and devices and also antiviral formulations and vaccines for coronaviruses.

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Section: Nanoparticles For Anti-coronavirus Therapeuticsmentioning

confidence: 99%

Section: Nanoparticles For Anti-coronavirus Therapeuticsmentioning

confidence: 99%

State-of-the-Art of Nanodiagnostics and Nanotherapeutics against SARS-CoV-2

Derakhshan

Amani

Faridi‐Majidi

2021

ACS Appl. Mater. Interfaces

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“…For example, some polar drugs or macromolecules are not absorbed in high enough concentrations for their poor membrane permeability, rapid clearance, and enzymatic degradation within the nasal cavity. And the nasal mucosa and physiological and anatomical factors, including nasal blood flow, enzymatic degradation, mucociliary clearance, the physical condition of the nose, including nasal atrophic rhinitis and severe vasomotor rhinitis, could also reduce the capacity of nasal drug absorption and bioavailability as Figure 3 (Sintov et al, 2010 ; Qian et al, 2014 ; Mansuri et al, 2016 ; Rohm et al, 2017 ; Inoue et al, 2018 ; Rohrer et al, 2018 ; Akel et al, 2020 ; Badhe and Nipate, 2020 ). These limitations must be addressed in the design of drug absorption by the nasal route.…”

Section: Nasal Drug Delivery Systemsmentioning

confidence: 99%

Design and Application in Delivery System of Intranasal Antidepressants

Tao

Wang

2020

Front. Bioeng. Biotechnol.

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One of the major reasons why depressed patients fail their treatment course is the existence of the blood-brain barrier (BBB), which prevents drugs from being delivered to the central nervous system (CNS). In recent years, nasal drug delivery has achieved better systemic bioavailability and activity in low doses in antidepressant treatment. In this review, we focused on the latest strategies for delivery carriers (or formation) of intranasal antidepressants. We began this review with an overview of the nasal drug delivery systems, including nasal drug delivery route, absorption mechanism, advantages, and limitations in the nasal drug delivery route. Next, we introduced the development of nasal drug delivery devices, such as powder devices, liquid-based devices, and so on. Finally, intranasal delivery carriers of antidepressants in clinical studies, including nanogels, nanostructured lipid, liposomes nanoparticles, nanoemulsions/microemulsion, were summarized. Moreover, challenges and future perspectives on recent progress of intranasal delivery carriers in antidepressant treatments were discussed.

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“…Allergic rhinitis (AR) is a highly prevalent chronic condition that impacts 400 million individuals globally and 100 million people in Europe. 1,2 Intranasal glucocorticoids, antihistamines, and disodium cromoglycate are all viable pharmaceutical therapy choices. Antihistamine sedation, disodium cromoglycate nasal mucosal irritation, and candidiasis are a few of the moderate side effects of these corticosteroid drugs.…”

Section: Introductionmentioning

confidence: 99%

Fructus Xanthii and Magnolia liliiflora Volatile Oils Liposomes-Loaded Thermosensitive in situ Gel for Allergic Rhinitis Management

Jing,

Li,

Liao

et al. 2024

IJN

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The aim of the present study was to fabricate a Fructus Xanthii and Magnolia liliiflora volatile oils liposomes-loaded thermosensitive in situ gel (gel/LIP/volatile oil) for effectively treating allergic rhinitis via intranasal administration. Patients and Methods: Particle size, polymer dispersity index (PDI), entrapment effectiveness, and cumulative drug permeation of the developed liposomes were assessed. Then, a thermoreversible in situ gel was created using the liposomes loaded with volatile oils of Fructus Xanthii and Magnolia liliiflora. The effectiveness of this treatment for allergic rhinitis was confirmed by evaluating nasal symptoms, and hematological results, after injecting the formulation into the ovalbumin (OVA)-sensitized mice, we conducted hematoxylin-eosin staining (HE) and immunohistochemistry to evaluate the outcomes. The effects of the gel/LIP/volatile oil formulation for nasal delivery of volatile oil in the treatment of rhinitis were then assessed. Results: The average particle size was 95.1 ± 3.6 nm, and the encapsulation efficiencies of Fructus Xanthii and Magnolia liliiflora volatile oils were 70.42 ± 5.41% and 67.10 ± 6.08%, respectively. Drug loadings of Fructus Xanthii and Magnolia liliiflora volatile oils were 9.10 ± 0.98% and 16.10 ± 1.03%, respectively. The binary formulation produced a gel rapidly in the nasal cavity with a strong mucosal adherence at a temperature of delivering volatile oil to the nasal mucosa steadily and continuously. After nasal administration, the gel/LIP/volatile oil sustained the volatile oil delivery into the mucosa. In comparison to the monolithic formulations, the gel/LIP/volatile oil binary formulation exhibited superior performance in terms of drug delivery capability and pharmacodynamic effects. Conclusion: This binary preparation displayed the ability to deliver drugs to the nasal mucosa and exhibited positive pharmacodynamic effects in treating OVA-induced rhinitis in mice. As a result, it has the potential to serve as a delivery platform for Traditional Chinese medicine in the treatment of allergic rhinitis.

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Nasal Bioadhesive Drug Delivery Systems and Their Applications

Cited by 11 publications

References 175 publications

State-of-the-Art of Nanodiagnostics and Nanotherapeutics against SARS-CoV-2

State-of-the-Art of Nanodiagnostics and Nanotherapeutics against SARS-CoV-2

Design and Application in Delivery System of Intranasal Antidepressants

Fructus Xanthii and Magnolia liliiflora Volatile Oils Liposomes-Loaded Thermosensitive in situ Gel for Allergic Rhinitis Management

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