Naringenin downregulates inflammation‐mediated nitric oxide overproduction and potentiates endogenous antioxidant status during hyperglycemia

Rehman, Kanwal; Khan, Ikram Ilahee; Akash, Muhammad Sajid Hamid; Jabeen, Komal; Haider, Kamran

doi:10.1111/jfbc.13422

Cited by 22 publications

(18 citation statements)

References 33 publications

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“…The therapeutic potential of hesperidin has been confirmed recently (Rehman et al, 2020b). This flavanone improved leptin and insulin resistance, IL-6 and TNF-α more significantly compared to the reference drug Orlistat used in high fat diet (HFD)-induced obese rats.…”

Section: Antibacterial Effectmentioning

confidence: 86%

Citrus species: Modern functional food and nutraceutical-based product ingredient

2021

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Citrus is the most cultivated fruit crop in the world and occupies a place of considerable importance in the country’s economy. Almost 33% of the citrus fruits are processed for juice production; however, a great amount of wastes, including peels, segment membranes, and seeds are also produced. Indeed, citrus fruits consist of 45% juice, 26% pulp, 27% peels, and 2% seeds. Pruning, a cultural practice involving the removal of tree branches and limbs, was applied to improve fruit’s quality. A large amount of leaves are produced through pruning. These agri-food matrices contain a wide range of bioactive phytochemicals compared to fruits. The present review covers the past 5 years of research carried out in chemistry, health properties, and applications in food and nutraceutical industries of all portions of citrus fruit and its major bioactive compounds. Additionally, patents are also included.

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Section: Antibacterial Effectmentioning

confidence: 86%

Citrus species: Modern functional food and nutraceutical-based product ingredient

2021

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“…Naringin is a kind of citrus flavonoid with a variety of biological activities including significant anti-inflammatory activities [ 151 ]. Studies showed that naringin could inhibit the release of pro-inflammatory cytokine IL-1β and induce the expression of anti-inflammatory factor interleukin-10 (IL-10) and transforming growth factor β1(TGF-β1) [ 152 ].…”

Section: Natural Products With Anti-inflammatory Effects In Alzheimer...mentioning

confidence: 99%

Anti-Neuroinflammatory Potential of Natural Products in the Treatment of Alzheimer’s Disease

Deng

Yan

et al. 2023

Molecules

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Alzheimer’s disease (AD) is an age-related chronic progressive neurodegenerative disease, which is the main cause of dementia in the elderly. Much evidence shows that the onset and late symptoms of AD are caused by multiple factors. Among them, aging is the main factor in the pathogenesis of AD, and the most important risk factor for AD is neuroinflammation. So far, there is no cure for AD, but the relationship between neuroinflammation and AD may provide a new strategy for the treatment of AD. We herein discussed the main etiology hypothesis of AD and the role of neuroinflammation in AD, as well as anti-inflammatory natural products with the potential to prevent and alleviate AD symptoms, including alkaloids, steroids, terpenoids, flavonoids and polyphenols, which are available with great potential for the development of anti-AD drugs.

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“…In fact, naringenin is able to ameliorate hyperglycemia and to improve the secretion of insulin. Moreover, it has an action on the inflammatory status by decreasing cytokines like TNFα and IL-6 and increasing the activity of SOD [ 105 ]. Naringenin and hesperetin are aglycones, but they are often found in their glycosylated form called naringin (naringenin + neohexperidose) and hesperidin (hesperetin + rutinose).…”

Section: Structure and Function Of Grape Polyphenolmentioning

confidence: 99%

Grape Polyphenols in the Treatment of Human Skeletal Muscle Damage Due to Inflammation and Oxidative Stress during Obesity and Aging: Early Outcomes and Promises

et al. 2022

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Today, inactivity and high-calorie diets contribute to the development of obesity and premature aging. In addition, the population of elderly people is growing due to improvements in healthcare management. Obesity and aging are together key risk factors for non-communicable diseases associated with several co-morbidities and increased mortality, with a major impact on skeletal muscle defect and/or poor muscle mass quality. Skeletal muscles contribute to multiple body functions and play a vital role throughout the day, in all our activities. In our society, limiting skeletal muscle deterioration, frailty and dependence is not only a major public health challenge but also a major socio-economic issue. Specific diet supplementation with natural chemical compounds such as grape polyphenols had shown to play a relevant and direct role in regulating metabolic and molecular pathways involved in the prevention and treatment of obesity and aging and their related muscle comorbidities in cell culture and animal studies. However, clinical studies aiming to restore skeletal muscle mass and function with nutritional grape polyphenols supplementation are still very scarce. There is an urgent need for clinical studies to validate the very encouraging results observed in animal models.

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Naringenin downregulates inflammation‐mediated nitric oxide overproduction and potentiates endogenous antioxidant status during hyperglycemia

Cited by 22 publications

References 33 publications

Citrus species: Modern functional food and nutraceutical-based product ingredient

Citrus species: Modern functional food and nutraceutical-based product ingredient

Anti-Neuroinflammatory Potential of Natural Products in the Treatment of Alzheimer’s Disease

Grape Polyphenols in the Treatment of Human Skeletal Muscle Damage Due to Inflammation and Oxidative Stress during Obesity and Aging: Early Outcomes and Promises

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