Anti-Neuroinflammatory Potential of Natural Products in the Treatment of Alzheimer’s Disease

Deng, Mingzhenlong; Yan, Wanli; Gu, Zhicheng; Li, Yan; Chen, Lei; He, Bin

doi:10.3390/molecules28031486

Cited by 13 publications

(11 citation statements)

References 226 publications

(285 reference statements)

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“…The results suggest that MH reduces ROS production while simultaneously enhancing the expression of Nrf2 and HO-1, which is consistent with the concept that high levels of Nrf2 and HO-1 can inhibit the production of NO induced by LTA. 45 Therefore, MH may exert anti-inflammatory and antioxidant effects by activating the Nrf2/HO-1 antioxidant pathway.…”

Section: Discussionmentioning

confidence: 99%

Morin hydrate suppresses lipoteichoic acid-induced oxidative stress-mediated inflammatory events in macrophages via augmenting Nrf2/HO-1 and antioxidant defense molecules

Hsieh,

Jayakumar,

Lin

et al. 2023

Eur J Inflamm

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Objectives Oxidative stress induces chronic inflammatory diseases in aerobic organisms, and antioxidants from plants represent an efficient strategy to prevent this condition. Morin hydrate (MH), a bioactive flavonoid, has a wide range of pharmacological properties, including anti-inflammatory and anti-oxidant. This study evaluated the protective effects of MH on lipoteichoic acid (LTA)-induced inflammation in RAW 264.7 macrophages by testing the main oxidative and inflammatory biomarkers and also investigating the molecular pathways involved. Methods The antioxidant and anti-inflammatory effects of MH were evaluated in a cell-free system and RAW264.7 cells. Quantitative real-time PCR (RT-qPCR) and assay kits were used to measure the expression of nuclear factor erythroid 2-related factor 2 (Nrf2) and heme oxygenase 1 (HO-1) mRNA, as well as the activity of antioxidant enzymes. The effects of MH on LTA-induced inducible nitric oxide synthase (iNOS), IL-1β, and TNF-α mRNA and protein expression were also evaluated by RT-qPCR and Western blotting. Results MH reduced DPPH and ABTS radicals in a cell-free system and LTA-induced ROS and NO production in RAW264.7 cells. MH upregulated Nrf2 and HO-1 mRNA expression and reversed LTA-mediated reduction of antioxidant enzymes, at a high concentration of 20 µM pretreated cells. MH also effectively attenuated LTA-induced iNOS, IL-1β, and TNF-α mRNA and protein expression, and these effects were reversed by ML385. Conclusions The study found that the Nrf2/HO-1 played role in the inhibition of LTA-induced oxidative stress in macrophages by MH. This study may consider to be a promising induced macrophage-targeted strategy via regulating anti-oxidative defense to control inflammatory-related disease.

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Section: Discussionmentioning

confidence: 99%

Morin hydrate suppresses lipoteichoic acid-induced oxidative stress-mediated inflammatory events in macrophages via augmenting Nrf2/HO-1 and antioxidant defense molecules

Hsieh,

Jayakumar,

Lin

et al. 2023

Eur J Inflamm

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“…Microglial activation is considered the first sign of neuroinflammation [22,35]. In the pathologies of NDDs, the initial activation is triggered by the detection of extracellular or intracellular pathogen-associated molecular patterns (PAMPs) or damage-associated molecular patterns (DAMPs) through pattern recognition receptors (PRRs), such as the best-known Toll-like receptors (TLRs) and nuclear oligomerization domain-like receptors (NLRs) [36].…”

Section: Activation Of Microgliamentioning

confidence: 99%

“…Due to their high accessibility, low toxicity, and potent anti-inflammatory properties, natural products (including alkaloids, steroids, terpenoids, flavonoids and polyphenols) have been proposed as potential agents for preventing and mitigating neuroinflammation [35,[83][84][85]. These natural products share the common feature of possessing a multitargeted approach and exert their potential neuroprotective properties by either inhibiting translocation of NF-kB dimers into the nucleus, regulating the release of proinflammatory cytokines and the production of inflammasomes, or inducing anti-inflammatory effects [86].…”

Section: Therapeutic Applications Of Immunomodulatory Medications In ...mentioning

confidence: 99%

Exploring the Potential of Aptamers in Targeting Neuroinflammation and Neurodegenerative Disorders: Opportunities and Challenges

Kong

et al. 2023

IJMS

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Neuroinflammation is the precursor for several neurodegenerative diseases (NDDs), such as Alzheimer’s disease (AD), Parkinson’s disease (PD), and multiple sclerosis (MS). Targeting neuroinflammation has emerged as a promising strategy to address a wide range of CNS pathologies. These NDDs still present significant challenges in terms of limited and ineffective diagnosis and treatment options, driving the need to explore innovative and novel therapeutic alternatives. Aptamers are single-stranded nucleic acids that offer the potential for addressing these challenges through diagnostic and therapeutic applications. In this review, we summarize diagnostic and therapeutic aptamers for inflammatory biomolecules, as well as the inflammatory cells in NDDs. We also discussed the potential of short nucleotides for Aptamer-Based Targeted Brain Delivery through their unique features and modifications, as well as their ability to penetrate the blood-brain barrier. Moreover, the unprecedented opportunities and substantial challenges of using aptamers as therapeutic agents, such as drug efficacy, safety considerations, and pharmacokinetics, are also discussed. Taken together, this review assesses the potential of aptamers as a pioneering approach for target delivery to the CNS and the treatment of neuroinflammation and NDDs.

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“…Currently, only five drugs are approved for the treatment of AD, highlighting the need for alternative therapies that can relieve symptoms but do not provide a cure or halt disease progression 8 . The human diet represents an important exogenous source of antioxidants and has drawn interest for AD therapy, with several natural compounds showing promising results in in vivo preclinical studies, alongside others already being studied in clinical trials 9 .…”

Section: Introductionmentioning

confidence: 99%

Antioxidant and anti-Alzheimer's potential of Tetragonisca angustula (Jataí) stingless bee pollen

dos Santos,

Malta,

Franco

et al. 2024

Sci Rep

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Alzheimer's disease (AD) is considered the leading cause of dementia in the elderly worldwide. It results in progressive memory loss and impairment of cognitive and motor skills, leading to a high degree of disability and dependence. The development of AD is associated with the accumulation of senile plaques in the brain, caused by the amyloidogenic pathway of the disease. Several genetic and biochemical events are linked to AD development, with oxidative stress being one of them. Due to the scarcity of drugs aimed at treating AD, antioxidant compounds are increasingly studied as therapeutic targets for the disease. In this study, we investigate the antioxidant and anti-Alzheimer potential of the Tetragonisca angustula (Jataí) pollen extract in a Drosophila melanogaster Alzheimer's model. For this purpose, we utilized a D. melanogaster AD-like model, which expresses genes related to the amyloidogenic pathway of Alzheimer's disease. We explored the floral origin of the collected pollen, conducted phytochemical prospecting, and evaluated its antioxidant capacity in vitro. In vivo experiments involved assessing the survival and climbing ability of the D. melanogaster AD-like model with various concentrations of the pollen extract. Our findings revealed that the pollen extract of Tetragonisca angustula exhibits a significant antioxidant response and high concentrations of important phytochemicals, such as flavonoids and polyphenols. Furthermore, it enhanced the survival rate of D. melanogaster, and across all concentrations tested, it improved the climbing ability of the flies after 15 days of treatment with methanolic pollen extract. Additionally, the pollen extract reduced the neurodegeneration index in histopathological analysis. Thus, our study demonstrates the potential of Tetragonisca angustula pollen as an important subject for further investigation, aiming to isolate molecules that could potentially serve as therapeutic targets for Alzheimer's disease.

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Anti-Neuroinflammatory Potential of Natural Products in the Treatment of Alzheimer’s Disease

Cited by 13 publications

References 226 publications

Morin hydrate suppresses lipoteichoic acid-induced oxidative stress-mediated inflammatory events in macrophages via augmenting Nrf2/HO-1 and antioxidant defense molecules

Morin hydrate suppresses lipoteichoic acid-induced oxidative stress-mediated inflammatory events in macrophages via augmenting Nrf2/HO-1 and antioxidant defense molecules

Exploring the Potential of Aptamers in Targeting Neuroinflammation and Neurodegenerative Disorders: Opportunities and Challenges

Antioxidant and anti-Alzheimer's potential of Tetragonisca angustula (Jataí) stingless bee pollen

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