Naples, Italy

Wilding, Martin; Singer, Michael; Fehr, Peter; Haeberlin, Felix; Roth, Felix; Lachat, Remo; Matteo, Loredana Di; Capobianco, Clemente; Dale, Brian

doi:10.1007/s10815-005-9016-y

Cited by 5 publications

(1 citation statement)

References 28 publications

(41 reference statements)

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“…The assay was finally used for the study of three more complex sample matrixes: human serum, urine, and saliva. It is known that although the pH of blood is regulated in the body between 7.35 and 7.45, 47 the pH of saliva can range between 5.3 and 7.8, depending on the salivary flow, 48 and that of urine can vary between 4.4 and 8 and is determined by parameters such as an individual's diet, drugs intake, or health state. 49,50 In this study, dilution in PBS guaranteed that all samples showed a pH of around 7.4 before MP addition and that the pH did not affect DA immunocapture.…”

Section: Detection Of Da In Pbs and In Complex Sample Matrixesmentioning

confidence: 99%

Carbon Nanotube Wiring: A Tool for Straightforward Electrochemical Biosensing at Magnetic Particles

Baldrich

Muñoz

2011

Anal. Chem.

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Here, we combine the unique properties of carbon nanotubes (CNTs) and magnetic particles (MPs) to develop a novel biosensing approach for the specific detection of electroactive labels and targets. The assay is based on label/target capture and concentration using MPs. It follows addition of CNTs, which adsorb onto the surface of the beads. The subsequent magnetic entrapment of the CNT/MP complexes onto an electrode allows straightforward electrochemical sensing of the MP surface by exploiting CNT wiring. As a proof of concept, the assay has been applied to detection of ferrocene labels, and to the specific immunodetection of dopamine in both artificial saline solutions and real sample matrixes. The results demonstrate the applicability of CNT as wiring tools for enzymeless and substrateless electrochemical biosensing.

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Section: Detection Of Da In Pbs and In Complex Sample Matrixesmentioning

confidence: 99%