The MAK‐Collection for Occupational Health and Safety 2018
DOI: 10.1002/3527600418.bb9120e2218
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Naphthalene [BAT Value Documentation, 2018]

Abstract: The German Commission for the Investigation of Health Hazards of Chemical Compounds in the Work Area has evaluated a BAR (“Biologischer Arbeitsstoff Referenzwert”) for naphthalene, considering 1‐ and 2‐naphthol in urine to characterize the internal exposure. Naphthalene is classified in category 2 for carcinogenic substances and designated with an “H” because of its contribution to the toxicological hazards due to penetration through the skin in vitro and dermal absorption in vivo. In a number of bio… Show more

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Cited by 6 publications
(7 citation statements)
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“…1-NAP and 2-NAP are excreted in the urine as glucuronide and sulfate conjugates. 6 In order to cleave these conjugates, enzymatic hydrolysis was carried out according to the procedure employed in a previous study. 10 IS 1 (5000 µg/L, 20 µL), 0.5 mol/L acetate buffer (pH 5.0, 1 mL), and β-glucuronidase/ arylsulfatase (20 µL) were added to a glass test tube containing urine (2 mL).…”
Section: Sample Preparationmentioning
confidence: 99%
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“…1-NAP and 2-NAP are excreted in the urine as glucuronide and sulfate conjugates. 6 In order to cleave these conjugates, enzymatic hydrolysis was carried out according to the procedure employed in a previous study. 10 IS 1 (5000 µg/L, 20 µL), 0.5 mol/L acetate buffer (pH 5.0, 1 mL), and β-glucuronidase/ arylsulfatase (20 µL) were added to a glass test tube containing urine (2 mL).…”
Section: Sample Preparationmentioning
confidence: 99%
“…6 Among them, 1-naphthol (1-NAP) and 2-naphthol (2-NAP) have been used as biomarkers for exposure to naphthalene in humans. 6 For non-smokers, the DFG has proposed a biological reference value (Biologischer Arbeitsstoff-Referenzwert, BAR) of 35 μg/L (after hydrolysis) for 1-NAP plus 2-NAP in urine. 6 This BAR defines the urinary 1-NAP and 2-NAP level in the population who are not occupationally exposed to naphthalene (ie, the background level).…”
Section: Introductionmentioning
confidence: 99%
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