Validity of different biomonitoring parameters in human urine for the assessment of occupational exposure to naphthalene

Klotz, K.; Weiß, Tobias; Zobel, Melanie; Bury, Daniel; Breuer, D.; Werner, Silke; Sucker, Kirsten; Zschiesche, W; Göen, Thomas; Brüning, Thomas; Drexler, Hans

doi:10.1007/s00204-019-02468-9

Cited by 7 publications

(9 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The purpose of Article 3 (Klotz et al, 2019) is to investigate the correlation between occupational naphthalene exposure and biological exposure markers. It collected urine samples from workers who had been exposed to naphthalene in industrial abrasives.…”

Section: Resultsmentioning

confidence: 99%

“…Article 3 (Klotz et al, 2019) and Article 4 (Klotz et al, 2018) were produced by the same first author. Previously it was stated that Article 4 (Klotz et al, 2018) did not find correlations between external and internal naphthalene exposure, so in Article 3 (Klotz et al, 2019) the data were re-analyzed statistically, resulting in a significant correlation (p<0.01) with a strong Pearson's correlation coefficient (R2=0.944). Using the correlation, the biomarker equivalent concentration in urine can be calculated in relation to occupational exposure limits in workplace's water.…”

Section: Discussionmentioning

confidence: 99%

“…Using the correlation, the biomarker equivalent concentration in urine can be calculated in relation to occupational exposure limits in workplace's water. The biomarker equivalent concentration for the occupational exposure limit (OEL) of 2 mg/m 3 can be calculated up to 4940 μg/L for 1,2-DHN (Klotz et al, 2019).…”

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

1,2-dihydroxynaphthalene as Biomonitoring of Occupational Exposure to Naphthalene

Budiman

Ilyas

2022

IJOSH

View full text Add to dashboard Cite

Introduction: Naphthalene is a chemical exposure found in various industries, including in the manufacture of phthalic anhydride, synthetic resins, lubricants, mothballs, and used as fuel additives. The exposure to naphthalene in humans has several detrimental health effects such as hemolytic anemia, kidney and liver disorders. Therefore, biological monitoring is needed as a health surveillance of naphthalene exposure. Generally, the biomonitoring examination carried out for this is naphthol in the blood. However, 1,2-dihydroxynaphthalene (1,2-DHN) is also known to be another major metabolite. Therefore, this literature review aims to determine whether 1,2-DHN can also be a reliable biomonitoring test on occupational exposure to naphthalene. Methods: PubMed, Proquest, and Google Scholar were used to conduct article searches. The articles were chosen based on predetermined inclusion and exclusion criteria. The selected articles were then critically appraised. Results: Four cross-sectional articles examining 1,2-DHN in the urine of naphthalene-exposed workers were selected and reviewed. There was a similar result from all selected articles that elevated levels of 1,2-DHN in the urine, indicating workplace exposure to naphthalene. Moreover, apart from having a strong correlation with 1- and 2-naphthol, 1,2-DHN also has a high sensitivity compared to these established metabolites. Conclusion: Based on the articles obtained, 1,2-DHN can be a reliable biological monitoring for workers exposed to naphthalene. However, further research is still needed on other industries exposed to naphthalene and is needed to ascertain the correlation between external and internal exposure to naphthalene.

show abstract

Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

1,2-dihydroxynaphthalene as Biomonitoring of Occupational Exposure to Naphthalene

Budiman

Ilyas

2022

IJOSH

View full text Add to dashboard Cite

show abstract

“…Also relevant are aldo-keto reductase (AKR) pathways. For example, 1,2dihydroxynaphthalene, which results from the AKR pathways, is by far the main urinary metabolite of naphthalene [20]. This urinary metabolite has shown a strong correlation with environmental naphthalene exposure, which supports its use as a biomarker for the human biomonitoring of naphthalene exposure as an alternative for more commonly used 1-and 2-naphthol [20].…”

Section: Introductionmentioning

confidence: 86%

“…For example, 1,2dihydroxynaphthalene, which results from the AKR pathways, is by far the main urinary metabolite of naphthalene [20]. This urinary metabolite has shown a strong correlation with environmental naphthalene exposure, which supports its use as a biomarker for the human biomonitoring of naphthalene exposure as an alternative for more commonly used 1-and 2-naphthol [20]. Pyrene is frequently found in PAH mixtures and its urinary metabolite, 1-hydroxypyrene (1-OH-PYR), has been commonly used as an indicator of exposure to PAHs [21,22].…”

Section: Introductionmentioning

confidence: 99%

The Use of Human Biomonitoring to Assess Occupational Exposure to PAHs in Europe: A Comprehensive Review

Louro

Gomes

Saber

et al. 2022

Toxics

Self Cite

View full text Add to dashboard Cite

Polycyclic aromatic hydrocarbons (PAHs) are among the chemicals with proven impact on workers’ health. The use of human biomonitoring (HBM) to assess occupational exposure to PAHs has become more common in recent years, but the data generated need an overall view to make them more usable by regulators and policymakers. This comprehensive review, developed under the Human Biomonitoring for Europe (HBM4EU) Initiative, was based on the literature available from 2008–2022, aiming to present and discuss the information on occupational exposure to PAHs, in order to identify the strengths and limitations of exposure and effect biomarkers and the knowledge needs for regulation in the workplace. The most frequently used exposure biomarker is urinary 1-hydroxypyrene (1-OH-PYR), a metabolite of pyrene. As effect biomarkers, those based on the measurement of oxidative stress (urinary 8-oxo-dG adducts) and genotoxicity (blood DNA strand-breaks) are the most common. Overall, a need to advance new harmonized approaches both in data and sample collection and in the use of appropriate biomarkers in occupational studies to obtain reliable and comparable data on PAH exposure in different industrial sectors, was noted. Moreover, the use of effect biomarkers can assist to identify work environments or activities of high risk, thus enabling preventive risk mitigation and management measures.

show abstract

Analysis of urinary metabolites of polycyclic aromatic hydrocarbons and cotinine in pooled urine samples to determine the exposure to PAHs in an Australian population.

Thai

Banks

Toms

et al. 2020

Environmental Research

View full text Add to dashboard Cite

Validity of different biomonitoring parameters in human urine for the assessment of occupational exposure to naphthalene

Cited by 7 publications

References 21 publications

1,2-dihydroxynaphthalene as Biomonitoring of Occupational Exposure to Naphthalene

1,2-dihydroxynaphthalene as Biomonitoring of Occupational Exposure to Naphthalene

The Use of Human Biomonitoring to Assess Occupational Exposure to PAHs in Europe: A Comprehensive Review

Analysis of urinary metabolites of polycyclic aromatic hydrocarbons and cotinine in pooled urine samples to determine the exposure to PAHs in an Australian population.

Contact Info

Product

Resources

About