Nanotechnology, Inflammation and the Skin Barrier: Innovative Approaches for Skin Health and Cosmesis

Landriscina, Angelo; Rosen, Jamie; Friedman, Adam

doi:10.3390/cosmetics2020177

Cited by 22 publications

(22 citation statements)

References 29 publications

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“…This field aims at designing materials with new functions and beneficial properties at the nanometer level [10]. The nanomaterials designed are mostly any shape with a size in the range of 1-100 nm [11]. The huge and unique advantages that nanoparticles (NPs) offer made them an important research in the medical field, which created a new field called nanomedicine [12].…”

Section: Nanotechnologymentioning

confidence: 99%

“…Dermatologic therapy is mainly aimed to prevent or decrease inflammation in the skin. Topical corticosteroids are the keystone of dermatologic therapy and have been used for various inflammatory conditions for their treatment or prevention [11]. Corticosteroids are often prescribed, though their use can carry significant side effects, as mentioned earlier.…”

Section: Dermatitismentioning

confidence: 99%

“…In several studies, SLN corticosteroid formulations showed increased penetration compared to its traditional counterparts, resulting in penetration beyond the epidermis and into the dermis [11]. Moreover, SLN provide the added benefit of sustained release, which is a desirable feature for controlling concentration of drug in tissue over time; these properties may improve side effect profiles and dosing schedules of drugs.…”

Section: Dermatitismentioning

confidence: 99%

“…Inorganic UV filters such as titanium oxide (TiO 2 ) and zinc oxide (ZnO) have been used in sunscreen formulations for a long time, and they are effective in protecting against both UVA and UVB rays. Despite that, TiO 2 and ZnO filters leave an opaque white residue on the skin, which limits its use by many customers [11]. However, by reducing TiO 2 and ZnO sizes to the nanoscale, the production of translucent products is possible rather than the white coarse raw material.…”

Section: Dermatitismentioning

confidence: 99%

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The Potential Contribution of Nanoparticles in the Treatment of Inflammatory Diseases

Elsayed¹,

Norredin²

2020

Translational Studies on Inflammation

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The scope of this chapter is to review the significant effect that nanomedicine has had in the treatment of inflammatory diseases. Nanotechnology has been widely studied in the last decade and proved to be an encouraging strategy in the healthcare system and the medical field. This novel technology provides a vast number of nanomaterials and tools that could actually diagnose and treat different inflammatory disorders and conditions. An enormous amount of in vivo and in vitro research was conducted by many groups to validate the positive contribution that nanoparticles have in regard to the treatment of inflammation and its associated illnesses. This contribution is due to the fact that nanoparticles could be modulated to pass through metabolic barriers and specifically targeted to deliver drugs to the required sites without affecting healthy cells and tissues. This makes them a promising therapeutical choice for the treatment of inflammatory diseases in the future.

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Section: Nanotechnologymentioning

confidence: 99%

Section: Dermatitismentioning

confidence: 99%

Section: Dermatitismentioning

confidence: 99%

Section: Dermatitismentioning

confidence: 99%

See 2 more Smart Citations

The Potential Contribution of Nanoparticles in the Treatment of Inflammatory Diseases

Elsayed¹,

Norredin²

2020

Translational Studies on Inflammation

View full text Add to dashboard Cite

show abstract

“…Nanotechnology is considered the most powerful and promising strategy of the 21st century providing innovative solutions and new opportunities to modern cosmetic dermatology through the investigation of the unique properties of matter at the nanoscale [1][2][3][4]. In particular, nanoparticles, recognized for their potential to penetrate human skin, are increasingly used to enhance the topical delivery of cosmetic ingredients and also to give stability to formulations that contain easily degradable materials [5][6][7].…”

Section: Introductionmentioning

confidence: 99%

Simil-Microfluidic Nanotechnology in Manufacturing of Liposomes as Hydrophobic Antioxidants Skin Release Systems

Bochicchio¹,

Dalmoro

Simone

et al. 2020

Cosmetics

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Novel nanotechnologies represent the most attractive and innovative tools to date exploited by cosmetic companies to improve the effectiveness of their formulations. In this context, nanoliposomes have had a great impact in topical preparations and dermocosmetics, allowing the transcutaneous penetration and absorption of several active ingredients and improving the stability of sensitive molecules. Despite the recent boom of this class of delivery systems, their industrial production is still limited by the lack of easily scalable production techniques. In this work, nanoliposomes for the topical administration of vitamin D3, K2, E, and curcumin, molecules with high antioxidant and skin curative properties but unstable and poorly absorbable, were produced through a novel simil-microfluidic technique. The developed high-yield semi continuous method is proposed as an alternative to face the problems linked with low productive conventional methods in order to produce antioxidant formulations with improved features. The novel technique has allowed to obtain a massive production of stable antioxidant vesicles of an 84–145 nm size range, negatively charged, and characterized by high loads and encapsulation efficiencies. The obtained products as well as the developed high-performance technology make the achieved formulations very interesting for potential topical applications in the cosmetics/cosmeceutical field.

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Recent Progress in Skin‐on‐a‐Chip Platforms

Cui

Wiraja

Zheng

et al. 2021

Advanced Therapeutics

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As the largest organ of the body, the skin acts as a physical barrier for preventing excessive water loss and infection, and the host of many cosmetic and pharmaceutical products. Currently, two-dimensional (2D) cell culture and animal models are extensively used as mainstream platforms to understand skin biology and assess therapeutic drug efficacy. However, 2D cell culture model fails to recapitulate the intricate interactions between cells and the extracellular matrix. The metabolic state of 2D-cultured cells is typically similar, unlike the physiological condition in the body. Also, there is a growing ethical concern over the use of animal studies. Significant advances in microfluidics and tissue engineering have led to the development of three-dimensional (3D) skin-on-a-chip (SOC) technology, which offers a cost-effective alternative to conventional preclinical models for the validation and testing of pharmaceutical and cosmetic products. This review discusses the recent developments in the design of various SOCs, their fabrication strategies and methods for introducing skill cells to the chip, and their respective biomedical applications. Finally, an outlook on current applications, challenges, and future research direction in this field is provided.

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Nanotechnology, Inflammation and the Skin Barrier: Innovative Approaches for Skin Health and Cosmesis

Cited by 22 publications

References 29 publications

The Potential Contribution of Nanoparticles in the Treatment of Inflammatory Diseases

The Potential Contribution of Nanoparticles in the Treatment of Inflammatory Diseases

Simil-Microfluidic Nanotechnology in Manufacturing of Liposomes as Hydrophobic Antioxidants Skin Release Systems

Recent Progress in Skin‐on‐a‐Chip Platforms

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