The Potential Contribution of Nanoparticles in the Treatment of Inflammatory Diseases

Abstract

The scope of this chapter is to review the significant effect that nanomedicine has had in the treatment of inflammatory diseases. Nanotechnology has been widely studied in the last decade and proved to be an encouraging strategy in the healthcare system and the medical field. This novel technology provides a vast number of nanomaterials and tools that could actually diagnose and treat different inflammatory disorders and conditions. An enormous amount of in vivo and in vitro research was conducted by many groups to validate the positive contribution that nanoparticles have in regard to the treatment of inflammation and its associated illnesses. This contribution is due to the fact that nanoparticles could be modulated to pass through metabolic barriers and specifically targeted to deliver drugs to the required sites without affecting healthy cells and tissues. This makes them a promising therapeutical choice for the treatment of inflammatory diseases in the future.

Recent advances in herbal-based nanomedicine for anti-inflammatory purposes

“…These structures are produced from solid lipids and they are stabilized through surfactants. SLNs size ranges from 50 to 1000nm and they can be used for the delivery of drugs by using different routes of administration such as oral and parenteral route, they combine the advantages of liposomes and polymeric nanoparticles as they have low toxicity, high physicochemical stability, and offer good protection against drug degradation 11 .…”

Potential of nanoparticles and nanopolymers in treatment of age-associated diseases

“…In spite of the therapeutic potential of bioactive nanoparticles in the treatment of diseases initiated by chronic inflammation, still, further studies are required to overcome their potential toxicity and identify their pharmacokinetic properties, such as the least effective concentrations, physicochemical interactions, route of administration, etc. (Elsayed & Norredin, 2019). New advances in nanotechnology and nanomedicine-based strategies have led to the emergence of nanomedicine for the inflammatory disease treatments that can be directly effective in delaying aging (Table 6 ) (Rizzuto et al, 2019).…”

The Impact of Zinc Oxide Nanoparticles on Male (In)Fertility

“…Several studies have indicated that ZnO NPs have different mechanisms for inflammation inhibition that are very useful in autoimmune [43] and inflammatory diseases and in drug designing and targeting, as well as in the food and cosmetic industry. They may also offer a plausible solution for cancer and various types of inflammation treatment using, for instance, UV rays with minimal side-effects [39,[48][49][50]. Interesting studies regarding atopic dermatitis revealed that ZnO NPs treatment decreases local skin inflammation on a mouse model with atopic dermatitis [51] and patients with atopic dermatitis [52], as a result of the anti-inflammatory properties of ZnO NPs [51,52], as well as high antioxidative and anti-bacterial capacities [52].…”