Nanotechnology for colorectal cancer detection and treatment

Gogoi, Purnima; Kaur, Geetika; Singh, Nikhlesh K.

doi:10.3748/wjg.v28.i46.6497

Cited by 22 publications

(14 citation statements)

References 94 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Nanotechnology has gained increasing interest in recent years due to its significant contribution to CRC treatment. 6 Oral treatment by NP-targeting drugs is a promising delivery to accumulate antineoplastic compounds in tumor colon sites and increase therapeutic efficacy. PLGA NPs have been used to encapsulate and preserve 5-FU, enhancing its levels in CRC cells.…”

Section: Nps In Crc Therapymentioning

confidence: 99%

“… 4 In this light, the knowledge of the molecular mechanisms and the genetic signature of cancer has contributed to the optimization of the treatment, determining a significant increase of patient survival. 5 A successful treatment, preventing side effects and cytotoxicity to healthy tissues and organs by selectively targeting tumor tissues 6 could result from the design of new therapeutics based on nanoparticles (NPs), delivering small non-coding RNAs, such as microRNAs (miRNAs), 7 which act as oncogenic or tumor suppressor players at the epigenetic level.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

MicroRNA-nanoparticles against cancer: Opportunities and challenges for personalized medicine

Martino¹,

Anastasio²,

Abate³

et al. 2023

Molecular Therapy - Nucleic Acids

View full text Add to dashboard Cite

Section: Nps In Crc Therapymentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

MicroRNA-nanoparticles against cancer: Opportunities and challenges for personalized medicine

Martino¹,

Anastasio²,

Abate³

et al. 2023

Molecular Therapy - Nucleic Acids

View full text Add to dashboard Cite

“…Some countries of South America and Africa along with Asian countries like China and India endure a low-risk for CRC. 5 …”

Section: Introductionmentioning

confidence: 99%

“…Explicitly, CRC remains a leading cause of death as the CANZUK countries and the United States remain high-risk countries. Some countries of South America and Africa along with Asian countries like China and India endure a low-risk for CRC …”

Section: Introductionmentioning

confidence: 99%

“…Some countries of South America and Africa along with Asian countries like China and India endure a low-risk for CRC. 5 The current treatment options for early diagnosis and treatment of CRC lack precision and pose side effects in addition to occurrence of resistance among cancer cells. Nanoparticles can be useful in this regard as they are effective diagnostic and therapeutic agents and reduce side-effects as they can increase solubility of drugs being loaded into organized sequences.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Carbon-Based Nanomaterials as Drug Delivery Agents for Colorectal Cancer: Clinical Preface to Colorectal Cancer Citing Their Markers and Existing Theranostic Approaches

Wang

Ding

et al. 2023

ACS Omega

View full text Add to dashboard Cite

Colorectal cancer (CRC) is one of the universally established cancers with a higher incidence rate. Novel progression toward cancer prevention and cancer care among countries in transition should be considered seriously for controlling CRC. Hence, several cutting edge technologies are ongoing for high performance cancer therapeutics over the past few decades. Several drug-delivery systems of the nanoregime are relatively new in this arena compared to the previous treatment modes such as chemoor radiotherapy to mitigate cancer. Based on this background, the epidemiology, pathophysiology, clinical presentation, treatment possibilities, and theragnostic markers for CRC were revealed. Since the use of carbon nanotubes (CNTs) for the management of CRC has been less studied, the present review analyzes the preclinical studies on the application of carbon nanotubes for drug delivery and CRC therapy owing to their inherent properties. It also investigates the toxicity of CNTs on normal cells for safety testing and the clinical use of carbon nanoparticles (CNPs) for tumor localization. To conclude, this review recommends the clinical application of carbon-based nanomaterials further for the management of CRC in diagnosis and as carriers or therapeutic adjuvants.

show abstract