MicroRNA-nanoparticles against cancer: Opportunities and challenges for personalized medicine

Martino, Elisa; Anastasio, Camilla; Abate, Marianna; Zappavigna, Silvia; Caraglia, Michele; Balestrieri, Maria Luisa

doi:10.1016/j.omtn.2023.03.021

Cited by 8 publications

(4 citation statements)

References 146 publications

(194 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Therapeutically targeting such miRNAs can potentially resensitize tumors to chemotherapy. a significant challenges in miRNA-based therapy is effective delivery to tumor cells; diverse nanoparticles loaded with miRNAs and are being explored for targeted delivery with minimal side effects [ 46 ]. …”

Section: Discussionmentioning

confidence: 99%

Cellular signaling modulated by miRNA-3652 in ovarian cancer: unveiling mechanistic pathways for future therapeutic strategies

Imran,

Iqbal,

Abid

et al. 2023

Cell Commun Signal

View full text Add to dashboard Cite

MicroRNAs (miRNAs) are small non-coding RNA molecules that play pivotal roles in regulating gene expression and have been implicated in the pathogenesis of numerous cancers. miRNA-3652, though relatively less explored, has recently emerged as a potential key player in ovarian cancer's molecular landscape. This review aims to delineate the functional significance and tumor progression role of miRNA-3652 in ovarian cancer, shedding light on its potential as both a diagnostic biomarker and therapeutic target. A comprehensive literature search was carried out using established databases, the focus was on articles that reported the role of miRNA-3652 in ovarian cancer, encompassing mechanistic insights, functional studies, and its association with clinical outcomes. This updated review highlighted that miRNA-3652 is intricately involved in ovarian cancer cell proliferation, migration, and invasion, its dysregulation was linked to altered expression of critical genes involved in tumor growth and metastasis; furthermore, miRNA-3652 expression levels were found to correlate with clinical stages, prognosis, and response to therapy in ovarian cancer patients. miRNA-3652 holds significant promise as a vital molecular player in ovarian cancer's pathophysiology. Its functional role and impact on tumor progression make it a potential candidate for diagnostic and therapeutic applications in ovarian cancer. Given the pivotal role of miRNA-3652 in ovarian cancer, future studies should emphasize in-depth mechanistic explorations, utilizing advanced genomic and proteomic tools. Collaboration between basic scientists and clinicians will be vital to translating these findings into innovative diagnostic and therapeutic strategies, ultimately benefiting ovarian cancer patients.

show abstract

Section: Discussionmentioning

confidence: 99%

Cellular signaling modulated by miRNA-3652 in ovarian cancer: unveiling mechanistic pathways for future therapeutic strategies

Imran,

Iqbal,

Abid

et al. 2023

Cell Commun Signal

View full text Add to dashboard Cite

show abstract

“…Currently, the integration of nanotechnology into male fertility preservation has the potential to revolutionize the field, providing more effective and personalized approaches to preserve male reproductive function and improve outcomes for individuals facing fertility challenges. Several types of nanoparticles have been investigated for the delivery of miRNAs in the landscape of cancer treatment, and their potential application in male fertility preservation is also very attractive [ 137 ] ( Figure 3 ). Lipid-based nanoparticles, such as liposomes and lipid nanoparticles (LNPs), have shown promise in mRNA/miRNA delivery due to their biocompatibility and ability to encapsulate and protect RNAs from degradation [ 138 , 139 ].…”

Section: Mirna Therapeutics: Limitations and Solutionsmentioning

confidence: 99%

The Role of microRNA in Spermatogenesis: Is There a Place for Fertility Preservation Innovation?

Klees,

Alexandri,

Demeestere

et al. 2023

IJMS

View full text Add to dashboard Cite

Oncological treatments have dramatically improved over the last decade, and as a result, survival rates for cancer patients have also improved. Quality of life, including concerns about fertility, has become a major focus for both oncologists and patients. While oncologic treatments are often highly effective at suppressing neoplastic growth, they are frequently associated with severe gonadotoxicity, leading to infertility. For male patients, the therapeutic option to preserve fertility is semen cryopreservation. In prepubertal patients, immature testicular tissue can be sampled and stored to allow post-cure transplantation of the tissue, immature germ cells, or in vitro spermatogenesis. However, experimental techniques have not yet been proven effective for restoring sperm production for these patients. MicroRNAs (miRNAs) have emerged as promising molecular markers and therapeutic tools in various diseases. These small regulatory RNAs possess the unique characteristic of having multiple gene targets. MiRNA-based therapeutics can, therefore, be used to modulate the expression of different genes involved in signaling pathways dysregulated by changes in the physiological environment (disease, temperature, ex vivo culture, pharmacological agents). This review discusses the possible role of miRNA as an innovative treatment option in male fertility preservation–restoration strategies and describes the diverse applications where these new therapeutic tools could serve as fertility protection agents.

show abstract

“…Over the last two decades, clear and definite evidence from numerous studies showed that epigenetics is deeply involved in modulating host immunity and tumorigenesis processes upon infections [3][4][5][6]. The epigenetic factor microRNA (miRNA) is reportedly involved in various bioprocesses, including oncogene functions and tumorigenesis suppression [7]. Host cellular miRNAs, like gga-miR-26a, gga-miR-181a, and gga-miR-130a, for instance, play a role in lymphoma cell proliferation suppression [8,9].…”

Section: Introductionmentioning

confidence: 99%

Epigenetic Factor MicroRNAs Likely Mediate Vaccine Protection Efficacy against Lymphomas in Response to Tumor Virus Infection in Chickens through Target Gene Involved Signaling Pathways

Zhang,

Xie,

Chang

et al. 2024

Veterinary Sciences

View full text Add to dashboard Cite

Epigenetic factors, including microRNAs (miRNAs), play an important role in affecting gene expression and, therefore, are involved in various biological processes including immunity protection against tumors. Marek’s disease (MD) is a highly contagious disease of chickens caused by the MD virus (MDV). MD has been primarily controlled by vaccinations. MD vaccine efficacy might, in part, be dependent on modulations of a complex set of factors including host epigenetic factors. This study was designed to identify differentially expressed miRNAs in the primary lymphoid organ, bursae of Fabricius, in response to MD vaccination followed by MDV challenge in two genetically divergent inbred lines of White Leghorns. Small RNA sequencing and bioinformatic analyses of the small RNA sequence reads identified hundreds of miRNAs among all the treatment groups. A small portion of the identified miRNAs was differentially expressed within each of the four treatment groups, which were HVT or CVI988/Rispens vaccinated line 63-resistant birds and line 72-susceptible birds. A direct comparison between the resistant line 63 and susceptible line 72 groups vaccinated with HVT followed by MDV challenge identified five differentially expressed miRNAs. Gene Ontology analysis of the target genes of those five miRNAs revealed that those target genes, in addition to various GO terms, are involved in multiple signaling pathways including MAPK, TGF-β, ErbB, and EGFR1 signaling pathways. The general functions of those pathways reportedly play important roles in oncogenesis, anti-cancer immunity, cancer cell migration, and metastatic progression. Therefore, it is highly likely that those miRNAs may, in part, influence vaccine protection through the pathways.

show abstract

MicroRNA-nanoparticles against cancer: Opportunities and challenges for personalized medicine

Cited by 8 publications

References 146 publications

Cellular signaling modulated by miRNA-3652 in ovarian cancer: unveiling mechanistic pathways for future therapeutic strategies

Cellular signaling modulated by miRNA-3652 in ovarian cancer: unveiling mechanistic pathways for future therapeutic strategies

The Role of microRNA in Spermatogenesis: Is There a Place for Fertility Preservation Innovation?

Epigenetic Factor MicroRNAs Likely Mediate Vaccine Protection Efficacy against Lymphomas in Response to Tumor Virus Infection in Chickens through Target Gene Involved Signaling Pathways

Contact Info

Product

Resources

About