Nanostructured MXene-based biomimetic enzymes for amperometric detection of superoxide anions from HepG2 cells

Smartphone‐coupled Electrochemical Analysis of Cellular Superoxide Anions Based on Mnx(PO4)y Monolayer Modified Porous Carbon

“…Nevertheless, the exploration of Mn x (PO 4 ) y for the usage in electrochemical sensor was limited due to the complicated and time‐consuming synthesis of Mn x (PO 4 ) y nanomaterials. Recently, Chen‘s and Li‘s groups have prepared Mn x (PO 4 ) y nanomaterials based on some phosphate‐containing biological molecules, such as DNA and ATP, respectively. Our group has come up with a facile way to synthesize Mn x (PO 4 ) y layer directly on some widely used carbon nanomaterials such as graphene oxide, nitrogen‐doped graphene sheet and carbon nanotubes, by using phytic acid and melamine.…”

“…As shown in Figure B, in the potential range of 0–+800 mV, bare SPE, PCC/SPE and MPSA/SPE exhibited no redox peaks while Mn‐MPSA/SPE presented a wide oxidative peak at around +400∼500 mV due to the transfer between Mn 2+ and MnO 2 + . The oxidative peak was wider when compared with some previous researches , and the reductive peak was not very obvious. This is mainly resulted from the different electrochemical device and three‐electrode‐system used in this work.…”

“…We further investigated the behaviour of Mn‐MPSA‐PCC toward superoxide dismutation by adding O 2 .− stock solution into the system. As displayed in Figure D, after different amount of O 2 .− was added into the system, the oxidative peak current as well as reductive current of Mn‐MPSA‐PCC/SPE was increased gradually, indicating that Mn‐MPSA‐PCC could catalyse both oxidation and reduction of O 2 .− . Manganese phosphate has been reported to present SOD‐mimic behaviour by a number of previous researches since that manganese phosphate can efficiently catalyze the dismutation of O 2 .− , which was also comfirmed by the enlarged redox current in Figure E after O 2 .− was added.…”

2D MXenes as Perspective Immobilization Platforms for Design of Electrochemical Nanobiosensors

“…Besides chitosan as a glue to deposit MXene onto the surface, Nafion proved to provide excellent results, as well with a final electrostatic immobilization of glucose oxidase (GOx) . Nafion was also applied to deposit MXene with adsorbed hemoglobin , MXene/Mn 3 (PO 4 ) 2 hybrid particles or MXene/TiO 2 mixed with hemoglobin on GCE . Furthermore, Nafion has a beneficial role in resisting interferences coming from negatively charged redox species such as ascorbic acid .…”

“…Hybrid MXene‐based nanocomposites can be prepared also from other materials besides precious metals. For example a nanocomposite based on MXene and a layer of Mn 3 (PO 4 ) 2 under ambient conditions using only agitation was prepared, as well .…”