Nanostructured lipid carriers as a favorable delivery system for β-carotene

Pezeshki, Akram; Hamishehkar, Hamed; Ghanbarzadeh, Babak; Fathollahy, Isa; Nahr, Fatemeh Keivani; Heshmati, Maryam Khakbaz; Mohammadi, Maryam

doi:10.1016/j.fbio.2018.11.004

Cited by 68 publications

(26 citation statements)

References 35 publications

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“…The high %EE can be due to its lipophilic properties, which leads to its higher ability into lipid matrix compared to aqueous phase (Ni, Zheng, Hara, Pan, & Luo, 2015). Similar results were gained by other researchers (Babazadeh et al, 2017; Keivani Nahr et al, 2018; Pezeshki et al., 2019), with high EE % more than 90% in all formulations.…”

Section: Resultssupporting

confidence: 90%

Conjugated linoleic acid loaded nanostructured lipid carrier as a potential antioxidant nanocarrier for food applications

Hashemi¹,

Farzadnia

Aghajani

et al. 2020

Food Science & Nutrition

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The encapsulation of fatty acids in nanocarrier systems is a very effective technique in improving their biological efficiency and controlled delivery. Nanostructured lipid carrier (NLC) is a major type of lipid‐based nanoparticle. This study is focused on producing nanolipid carrier containing conjugated linoleic acid and fortifying low‐fat milk using this nanoparticle. Nanostructured lipid carriers were produced by hot high‐shear homogenization containing 1.5% Poloxamer 407, cocoa butter as solid lipid, and conjugated linoleic acid as liquid oil in ratio of 10:1. Results showed that the nanoparticles sized 81 nm with monomodular dispersity and the system was stable at 4 and 22°C for 40 days. Zeta potential and encapsulation efficiency (%EE) were −15.8 mV and 98.2%, respectively. Scanning electron microscopy (SEM) showed that the particles are in spiral form and small size and no significant aggregation was observed because of few changes in the system turbidity after storage time. The result of oxidative stability showed that using Nanostructured lipid carriers system resulted in lower malone dialdehyde production. Conjugated linoleic acid was protected at level of 3.9% of milk fatty acids in Nanostructured lipid carrier formulation during storage time. Based on these findings, Nanostructured lipid carriers system is an appropriate and stable nanocarrier system for delivery of nutraceuticals in foods and can be used in protecting them against oxidation, heating, and other processes in order to fortify foods and beverages.

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Section: Resultssupporting

confidence: 90%

Conjugated linoleic acid loaded nanostructured lipid carrier as a potential antioxidant nanocarrier for food applications

Hashemi¹,

Farzadnia

Aghajani

et al. 2020

Food Science & Nutrition

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“…Then, the unloaded β‐carotene in the water phase was withdrawn and diluted with ethanol. The sample was analyzed using a Shimadzu UV‐2100 spectrophotometer (Tokyo, Japan) at 454 nm (Pezeshki et al., 2019) under validated calibration curve, that is, y = 1815 x + 0.0093 ( R 2 = .9951; accuracy of 103.7%; and precision of 3.2%) where y and x are the absorbance and β‐carotene concentration (µg/ml), respectively. EE was calculated according to the unloaded β‐carotene ( U ) and theoretical β‐carotene ( T ) using the following equation.

EE = \frac{()(, T ‐ U)}{T} \times 100 %

…”

Section: Methodsmentioning

confidence: 99%

Palm stearin and olein binary mixture incorporated into nanostructured lipids carrier: Improvement food functionality for micronutrient delivery

Rohmah

Choiri

Raharjo

et al. 2020

J. Food Process. Preserv.

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“…Other studies have reported the success of NLC in dissolving lipophilic components such as curcumin (Park et al, 2018), essential oil (Bashiri et al, 2020), vitamin D (Rabelo et al, 2018), lycopene (Sharma et al, 2021), β-carotene (Pezeshki et al, 2019), quercetin and piperine (Chaudhari et al, 2021).…”

Section: In Vitro Release Of βC From the βC-nlcmentioning

confidence: 99%

Bioaccessibility and antioxidant activity of β-carotene loaded nanostructured lipid carrier (NLC) from binary mixtures of palm stearin and palm olein

Rohmah

Rahmadi

Raharjo

2022

Heliyon

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activity of β-carotene loaded nanostructured lipid carrier (NLC) from binary mixtures of palm stearin and palm olein, HELIYON, https://doi.org/10.1016/j.heliyon.2022.e08913. This is a PDF file of an article that has undergone enhancements after acceptance, such as the addition of a cover page and metadata, and formatting for readability, but it is not yet the definitive version of record. This version will undergo additional copyediting, typesetting and review before it is published in its final form, but we are providing this version to give early visibility of the article. Please note that, during the production process, errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.

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Nanostructured lipid carriers as a favorable delivery system for β-carotene

Cited by 68 publications

References 35 publications

Conjugated linoleic acid loaded nanostructured lipid carrier as a potential antioxidant nanocarrier for food applications

Conjugated linoleic acid loaded nanostructured lipid carrier as a potential antioxidant nanocarrier for food applications

Palm stearin and olein binary mixture incorporated into nanostructured lipids carrier: Improvement food functionality for micronutrient delivery

Bioaccessibility and antioxidant activity of β-carotene loaded nanostructured lipid carrier (NLC) from binary mixtures of palm stearin and palm olein

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