Nanostructure-Mediated Drug Delivery

Hughes, Gareth A.

doi:10.1201/b22358-2

Cited by 34 publications

(41 citation statements)

References 1 publication

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“…The continuous reaction produces multiple layers of branches called “generations”, resulting in dendrimers with different sizes, shapes, and functionalities. Drug molecules may be covalently conjugated to the end groups of a dendrimer or entrapped inside the core via hydrogen bonding, hydrophobic linkage, or electrostatic interactions (Hughes, 2005). The number of generations influences the drug loading capacity: A relatively high generation number provides more space for guest drugs and has a larger number of functional groups on the surface for drug conjugation.…”

Section: Drug Release Control In Nanocarriersmentioning

confidence: 99%

Controlled drug release from pharmaceutical nanocarriers

Lee

Yeo

2015

Chemical Engineering Science

402

240

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Nanocarriers providing spatiotemporal control of drug release contribute to reducing toxicity and improving therapeutic efficacy of a drug. On the other hand, nanocarriers face unique challenges in controlling drug release kinetics, due to the large surface area per volume ratio and the short diffusion distance. To develop nanocarriers with desirable release kinetics for target applications, it is important to understand the mechanisms by which a carrier retains and releases a drug, the effects of composition and morphology of the carrier on the drug release kinetics, and current techniques for preparation and modification of nanocarriers. This review provides an overview of drug release mechanisms and various nanocarriers with a specific emphasis on approaches to control the drug release kinetics.

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Section: Drug Release Control In Nanocarriersmentioning

confidence: 99%

Controlled drug release from pharmaceutical nanocarriers

Lee

Yeo

2015

Chemical Engineering Science

402

240

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“…The goal is to develop drug or drug delivery vehicles with the ability to efficiently cross physiological barriers and reach to the desired locations for disease containment and control. Different nanoscale morphologies allow precise delivery of not only small-molecule drugs but also the delivery of nucleic acids and proteins that reduce systemic side effects [4, 103]. Surface of nanoparticles could be meso-porous, have tiny pores of 2–50 nm over the surface or non-porous, have plane surfaces that theoretically contain no pores [104].…”

Section: Morphological and Physicochemical Characterizationmentioning

confidence: 99%

Perspective on Nanoparticle Technology for Biomedical Use

Raliya¹,

Chadha²,

Haddad³

et al. 2016

CPD

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This review gives a short overview on the widespread use of nanostructured and nanocomposite materials for disease diagnostics, drug delivery, imaging and biomedical sensing applications. Nanoparticle interaction with a biological matrix/entity is greatly influenced by its morphology, crystal phase, surface chemistry, functionalization, physicochemical and electronic properties of the particle. Various nanoparticle synthesis routes, characteristization, and functionalization methodologies to be used for biomedical applications ranging from drug delivery to molecular probing of underlying mechanisms and concepts are described with several examples (150 references).

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“…Several drug carrier systems are currently under development [13]. Areas such as cancer pathology need innovative techniques and methods to improve the diagnostics and develop a cure for this deadly disease.…”

Section: Multifunctional Polyelectrolyte Capsules As Smart Delivery Vmentioning

confidence: 99%

“…They are far from covering the complete spectrum of nanotechnologically generated delivery and sensing systems, and many alternative systems have been published [13,14]. For delivery applications, the cargo desired is loaded into the capsule cavity.…”

mentioning

confidence: 99%