Nanosecond-order long–short fluorescence lifetime switchable encryption with enlarged coding capacity

Abstract

The turn-off fluorescent photoswitches for information encryption are constantly being developed. However, there are no reports about time-switchable (fluorescence lifetime-switchable) encryption to overcome the limitations of tunable encoding numbers in spectrally and temporally encoded libraries. Based on the double-exponential fitting of fluorescence lifetime, we propose, a fatigue-free and highly flexible switch between the amplitude-weighted average fluorescence lifetime (τm) and the intensity-weighted average fluorescence lifetime (τi), which will realize the supermultiplexed fluorescence lifetime switchable encryption. The potentially enormous library of different fluorescent lifetime combinations would facilitate the development of information security.

Near-Infrared Inorganic Nanomaterials for Precise Diagnosis and Therapy

“…Nanoparticles doped with appropriate lanthanide ions has proved to enhance NIR emission through energy trapping or suppress the up-conversion pathway ( Chen et al, 2017 ; Zhong et al, 2017 ). Fluorescence lifetime as a new dimension become highly useful in multichannel bioimaging ( Figure 2D ), which are independent of both colour and intensity ( Laviv et al, 2016 ; Fan et al, 2018 ; Zheng et al, 2018 ; Xie et al, 2020 ; Lukina et al, 2021 ; Luo et al, 2021 ). Zhang group designed NIR-II RENPs with tunable luminescence lifetimes for in vivo quantitative imaging ( Fan et al, 2018 ).…”