Nanoplatform-mediated calcium overload for cancer therapy

Yao, Junlie; Peng, Hao; Qiu, Yue; Li, Shunxiang; Xu, Xiawei; Wu, Aiguo; Yang, Fang

doi:10.1039/d1tb02721b

Cited by 29 publications

(20 citation statements)

References 82 publications

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“…Calcium overload can activate the GSDME protein, which induces pyroptosis in tumor cells and sensitizes immunotherapy. Currently, several methods, such as Ca 2+ nanoparticles and calcium hydride (CaH 2 ) administration, are being evaluated to induce calcium overload in tumor cells to assist immunotherapy and develop a new tumor treatment strategy, namely ion interference therapy 234 , 235 .…”

Section: Abnormal Cell Death Related To Lipid Peroxidation and Tumor ...mentioning

confidence: 99%

The role of lipid metabolic reprogramming in tumor microenvironment

Yang¹,

Wang²,

Song³

et al. 2023

Theranostics

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Metabolic reprogramming is one of the most important hallmarks of malignant tumors. Specifically, lipid metabolic reprogramming has marked impacts on cancer progression and therapeutic response by remodeling the tumor microenvironment (TME). In the past few decades, immunotherapy has revolutionized the treatment landscape for advanced cancers. Lipid metabolic reprogramming plays pivotal role in regulating the immune microenvironment and response to cancer immunotherapy. Here, we systematically reviewed the characteristics, mechanism, and role of lipid metabolic reprogramming in tumor and immune cells in the TME, appraised the effects of various cell death modes (specifically ferroptosis) on lipid metabolism, and summarized the antitumor therapies targeting lipid metabolism. Overall, lipid metabolic reprogramming has profound effects on cancer immunotherapy by regulating the immune microenvironment; therefore, targeting lipid metabolic reprogramming may lead to the development of innovative clinical applications including sensitizing immunotherapy.

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Section: Abnormal Cell Death Related To Lipid Peroxidation and Tumor ...mentioning

confidence: 99%

The role of lipid metabolic reprogramming in tumor microenvironment

Yang¹,

Wang²,

Song³

et al. 2023

Theranostics

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show abstract

“…B16F10 cells were used as the evaluation criteria, and a green fluorescence probe (Fluo-3 AM) was used to study the cellular calcium levels. It is acknowledged that an excessive amount of Ca 2+ may trigger Ca 2+ overload in cells to induce mitochondrial dysfunction (calcium ions interference therapy), which is recognized as a key factor in augmenting cell apoptosis. , Therefore, confocal laser scanning microscopy (CLSM) was first used to visualize B16F10 cells incubated with PBS (G1), PDA@CaP-SA (G2), PDA@siBRAF/CaP-SA (G3), and PDA@siBRAF/CaP-SA plus NIR (G4). As shown in Figure a, compared to the G1 group, the green Fluo-3 AM signals of Ca 2+ were increased in groups G2 and G3, confirming that Ca 2+ could release from the hydrogels following the degradation of CaP to affect cell function.…”

Section: Resultsmentioning

confidence: 99%

Biomineralized Polydopamine Nanoparticle-Based Sodium Alginate Hydrogels for Delivery of Anti-serine/Threonine Protein Kinase B-Rapidly Accelerated Fibrosarcoma siRNA for Metastatic Melanoma Therapy

Lu,

Song,

Zhang

et al. 2023

ACS Nano

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“…An oxidatively stressed environment will alter the protein functions and prevent the proper relay of the calcium signal in CAT-downregulated cancerous cells, resulting in unrestrained Ca 2+ build-up and cell death [167,168]. Similarly, nanosystems which used CaO 2 as an oxygen source and hematoporphyrin monomethyl as a photosensitizer have been synthesized and reported [169,170].…”

Section: Targeting Metal Ion Homeostasismentioning

confidence: 99%

Targeting Tumor Microenvironment by Metal Peroxide Nanoparticles in Cancer Therapy

Mbugua

2022

Bioinorganic Chemistry and Applications

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Solid tumors have a unique tumor microenvironment (TME), which includes hypoxia, low acidity, and high hydrogen peroxide and glutathione (GSH) levels, among others. These unique factors, which offer favourable microenvironments and nourishment for tumor development and spread, also serve as a gateway for specific and successful cancer therapies. A good example is metal peroxide structures which have been synthesized and utilized to enhance oxygen supply and they have shown great promise in the alleviation of hypoxia. In a hypoxic environment, certain oxygen-dependent treatments such as photodynamic therapy and radiotherapy fail to respond and therefore modulating the hypoxic tumor microenvironment has been found to enhance the antitumor impact of certain drugs. Under acidic environments, the hydrogen peroxide produced by the reaction of metal peroxides with water not only induces oxidative stress but also produces additional oxygen. This is achieved since hydrogen peroxide acts as a reactive substrate for molecules such as catalyse enzymes, alleviating tumor hypoxia observed in the tumor microenvironment. Metal ions released in the process can also offer distinct bioactivity in their own right. Metal peroxides used in anticancer therapy are a rapidly evolving field, and there is good evidence that they are a good option for regulating the tumor microenvironment in cancer therapy. In this regard, the synthesis and mechanisms behind the successful application of metal peroxides to specifically target the tumor microenvironment are highlighted in this review. Various characteristics of TME such as angiogenesis, inflammation, hypoxia, acidity levels, and metal ion homeostasis are addressed in this regard, together with certain forms of synergistic combination treatments.

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Nanoplatform-mediated calcium overload for cancer therapy

Abstract: Mitochondria, as the "the plant of power" of cells, have been extensively highlighted with biological functions of offering energy and participating in signaling pathways. In parallel, calcium (Ca2+) plays a...

Cited by 29 publications

References 82 publications

The role of lipid metabolic reprogramming in tumor microenvironment

The role of lipid metabolic reprogramming in tumor microenvironment

Biomineralized Polydopamine Nanoparticle-Based Sodium Alginate Hydrogels for Delivery of Anti-serine/Threonine Protein Kinase B-Rapidly Accelerated Fibrosarcoma siRNA for Metastatic Melanoma Therapy

Targeting Tumor Microenvironment by Metal Peroxide Nanoparticles in Cancer Therapy

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