Biomineralized Polydopamine Nanoparticle-Based Sodium Alginate Hydrogels for Delivery of Anti-serine/Threonine Protein Kinase B-Rapidly Accelerated Fibrosarcoma siRNA for Metastatic Melanoma Therapy

Lu, Jianxiu; Song, Jixin; Zhang, Peiying; Huang, Ying; Lu, Xiaomin; Dai, Hua; Xi, Juqun

doi:10.1021/acsnano.3c05563

Cited by 16 publications

(7 citation statements)

References 42 publications

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“…A large number of carboxyl groups are present along the sodium alginate chain, facilitating easy interaction of carboxyl groups with divalent cations (e.g., Ca 2+ and Mg 2+ ) to form hydrogels [ 24 ]. Further, when trivalent cations are added (e.g., Al 3+ and Fe 3+ ), they can interact with the three carboxylate groups to form a more compact network, thus generating metal–alginate hydrogels with high mechanical properties.…”

Section: Resultsmentioning

confidence: 99%

Dynamic monitoring soft tissue healing via visualized Gd-crosslinked double network MRI microspheres

Chen,

Cai,

Zhao

et al. 2024

J Nanobiotechnol

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By integrating magnetic resonance-visible components with scaffold materials, hydrogel microspheres (HMs) become visible under magnetic resonance imaging(MRI), allowing for non-invasive, continuous, and dynamic monitoring of the distribution, degradation, and relationship of the HMs with local tissues. However, when these visualization components are physically blended into the HMs, it reduces their relaxation rate and specificity under MRI, weakening the efficacy of real-time dynamic monitoring. To achieve MRI-guided in vivo monitoring of HMs with tissue repair functionality, we utilized airflow control and photo-crosslinking methods to prepare alginate-gelatin-based dual-network hydrogel microspheres (G-AlgMA HMs) using gadolinium ions (Gd (III)), a paramagnetic MRI contrast agent, as the crosslinker. When the network of G-AlgMA HMs degrades, the cleavage of covalent bonds causes the release of Gd (III), continuously altering the arrangement and movement characteristics of surrounding water molecules. This change in local transverse and longitudinal relaxation times results in variations in MRI signal values, thus enabling MRI-guided in vivo monitoring of the HMs. Additionally, in vivo data show that the degradation and release of polypeptide (K2 (SL)6 K2 (KK)) from G-AlgMA HMs promote local vascular regeneration and soft tissue repair. Overall, G-AlgMA HMs enable non-invasive, dynamic in vivo monitoring of biomaterial degradation and tissue regeneration through MRI, which is significant for understanding material degradation mechanisms, evaluating biocompatibility, and optimizing material design.

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Section: Resultsmentioning

confidence: 99%

Dynamic monitoring soft tissue healing via visualized Gd-crosslinked double network MRI microspheres

Chen,

Cai,

Zhao

et al. 2024

J Nanobiotechnol

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“…RNA-based therapies have shown great promise. Lu and his team ( 55 ) designed a versatile injectable hydrogel system for the treatment of melanoma. A calcium-phosphorus shell was constructed on the surface of dopamine nanoparticles through biosimulated mineralization to achieve efficient loading of siRNA.…”

Section: Hydrogels Loaded With Nucleic Acid Drugs For Melanoma Immuno...mentioning

confidence: 99%

Research progress on hydrogel-based drug therapy in melanoma immunotherapy

He,

Zhang,

et al. 2024

BMB Rep

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Melanoma is one of the most aggressive skin tumors, and conventional treatment modalities are not effective in treating advanced melanoma. Although immunotherapy is an effective treatment for melanoma, it has disadvantages, such as a poor response rate and serious systemic immune-related toxic side effects. The main solution to this problem is the use of biological materials such as hydrogels to reduce these side effects and amplify the immune killing effect against tumor cells. Hydrogels have great advantages as local slow-release drug carriers, including the ability to deliver antitumor drugs directly to the tumor site, enhance the local drug concentration in tumor tissue, reduce systemic drug distribution and exhibit good degradability. Despite these advantages, there has been limited research on the application of hydrogels in melanoma treatment. Therefore, this article provides a comprehensive review of the potential application of hydrogels in melanoma immunotherapy. Hydrogels can serve as carriers for sustained drug delivery, enabling the targeted and localized delivery of drugs with minimal systemic side effects. This approach has the potential to improve the efficacy of immunotherapy for melanoma. Thus, the use of hydrogels as drug delivery vehicles for melanoma immunotherapy has great potential and warrants further exploration.

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“…These findings were observed using the B16F10 melanoma cell line, renowned for its high metastatic potential, as the experimental model. 123 Sodium alginate was utilized in conjunction with hyaluronic acid gel and aptamer AS1411 to facilitate the delivery of 5-fluorouracil. The engineered platform within SkinEthic™ RHE tissues proved to be non-irritating and demonstrated cytotoxic effects on MCF7 neoplastic cells with high expression of nucleolin.…”

Section: Next-generation Wound Dressings: Complicated Skin Cancer Sol...mentioning

confidence: 99%

Advances in skin gene therapy: utilizing innovative dressing scaffolds for wound healing, a comprehensive review

Karimzadeh,

Soltani Fard,

Nadi

et al. 2024

J. Mater. Chem. B

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Biomineralized Polydopamine Nanoparticle-Based Sodium Alginate Hydrogels for Delivery of Anti-serine/Threonine Protein Kinase B-Rapidly Accelerated Fibrosarcoma siRNA for Metastatic Melanoma Therapy

Cited by 16 publications

References 42 publications

Dynamic monitoring soft tissue healing via visualized Gd-crosslinked double network MRI microspheres

Dynamic monitoring soft tissue healing via visualized Gd-crosslinked double network MRI microspheres

Research progress on hydrogel-based drug therapy in melanoma immunotherapy

Advances in skin gene therapy: utilizing innovative dressing scaffolds for wound healing, a comprehensive review

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