Nanoparticles for oral delivery: targeted therapy for inflammatory bowel disease

Li, Defeng; Yang, Meifeng; Xu, Haoming; Zhu, Min‐zheng; Zhang, Yuan; Tian, Cheng‐mei; Nie, Yuqiang; Wang, Jianyao; Liang, Yujie; Yao, Jun; Wang, Lisheng

doi:10.1039/d2tb01190e

Cited by 34 publications

(29 citation statements)

References 211 publications

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“…Chitosan, as a natural polysaccharide, has played an important role in biomedicine with the advantages of excellent biodegradability and biosafety . Diverse types of drug-loaded micro-/nanoparticles based on chitosan are designed for targeted drug delivery, possessing the features of sustained drug release and pH responsiveness. − Researchers have explored the use of chitosan microparticles loaded with drugs to treat colorectal cancer, showing good therapeutic effects. , The emulsification cross-linking method was introduced to fabricate chitosan microparticles (CMs) to load the drug. The scanning electron microscopy (SEM) image of CMs is shown in Figure b.…”

Section: Resultsmentioning

confidence: 99%

Multiscale Magnetic Hydrogel Robot with a Core–Shell Structure for Active Targeted Delivery

Chen

Zhang

Tian

et al. 2022

ACS Appl. Polym. Mater.

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Tremendous progress in applying small-scale magnetic robots for targeted drug delivery has sparked a growing interest among researchers. However, significant effort is needed to design and fabricate robots to meet the needs of clinical treatments, such as biocompatibility, biodegradation, and synergistic therapy. Here, we propose a multiscale magnetic hydrogel robot (MMHR) with a core–shell structure in which superparamagnetic nanoparticles and curcumin-loaded chitosan microparticles (CCMs) are encapsulated inside the core, while doxorubicin-loaded chitosan microparticles (DCMs) are embedded inside the shell. The core and shell of the MMHR are composed of pH-sensitive calcium alginate hydrogels that can alleviate the sudden release of drugs from CCMs and DCMs in gastric fluid. MMHRs can be precisely actuated to the target region through magnetic driving systems for further drug delivery. The experimental results demonstrate that the MMHR possesses superior obstacle-crossing ability and can successfully locomote on the surface of the intestine. Additionally, the co-delivery of doxorubicin and curcumin is realized through the different fabrication methods of CCMs and DCMs and shows excellent synergistic therapeutic effects against colon cancer cells. The powerful propulsion, good biocompatibility, and remarkable synergistic efficacy of the MMHR offer a promising route for active drug delivery through the gastrointestinal tract.

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Section: Resultsmentioning

confidence: 99%

Multiscale Magnetic Hydrogel Robot with a Core–Shell Structure for Active Targeted Delivery

Chen

Zhang

Tian

et al. 2022

ACS Appl. Polym. Mater.

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“…Although a detailed understanding of PDEVs is not present, their applications in cancer research and treatment have attracted a great deal of attention. Notably, the PDEVs display good safety and biocompatibility for future clinical applications [ 71 , 72 ]. Several groups consistently revealed that PDEVs displayed remarkable killing effects on cancer cells without significantly affecting normal cell growth [ 73 , 74 ].…”

Section: Introductionmentioning

confidence: 99%

Plant-derived extracellular vesicles (PDEVs) in nanomedicine for human disease and therapeutic modalities

Zhang

et al. 2023

J Nanobiotechnol

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Background The past few years have witnessed a significant increase in research related to plant-derived extracellular vesicles (PDEVs) in biological and medical applications. Using biochemical technologies, multiple independent groups have demonstrated the important roles of PDEVs as potential mediators involved in cell-cell communication and the exchange of bio-information between species. Recently, several contents have been well identified in PDEVs, including nucleic acids, proteins, lipids, and other active substances. These cargoes carried by PDEVs could be transferred into recipient cells and remarkably influence their biological behaviors associated with human diseases, such as cancers and inflammatory diseases. Main body of the abstract This review summarizes the latest updates regarding PDEVs and focuses on its important role in nanomedicine applications, as well as the potential of PDEVs as drug delivery strategies to develop diagnostic and therapeutic agents for the clinical management of diseases, especially like cancers. Conclusion Considering its unique advantages, especially high stability, intrinsic bioactivity and easy absorption, further elaboration on molecular mechanisms and biological factors driving the function of PDEVs will provide new horizons for the treatment of human disease.

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“…Nanoparticles have shown an encouraging and promising outlook for drug or gene delivery in IBD treatment [ 6 , 7 , 8 ]. The design of drug-loaded nanoparticles for delivery to the colon via oral administration has been used as a strategy to further amplify drug uptake into the inflamed tissue of the colon [ 1 , 9 ]. Nanoparticles have a great chance to reach and accumulate in inflamed tissues due to the loosening of tight junctional complexes [ 10 ].…”

Section: Introductionmentioning

confidence: 99%

Preparation and Characterization of a Novel Multiparticulate Dosage Form Carrying Budesonide-Loaded Chitosan Nanoparticles to Enhance the Efficiency of Pellets in the Colon

et al. 2022

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An attempt was made to conquer the limitation of orally administered nanoparticles for the delivery of budesonide to the colon. The ionic gelation technique was used to load budesonide on chitosan nanoparticles. The nanoparticles were investigated in terms of size, zeta potential, encapsulation efficiency, shape and drug release. Then, nanoparticles were pelletized using the extrusion–spheronization method and were investigated for their size, mechanical properties, and drug release. Pellets were subsequently coated with a polymeric solution composed of two enteric (eudragit L and S) and time-dependent polymers (eudragit RS) for colon-specific delivery. All formulations were examined for their anti-inflammatory effect in rats with induced colitis and the relapse of the colitis after discontinuation of treatment was also followed. The size of nanoparticles ranged between 288 ± 7.5 and 566 ± 7.7 nm and zeta potential verified their positive charged surface. The drug release from nanoparticles showed an initial burst release followed by a continuous release. Pelletized nanoparticles showed proper mechanical properties and faster drug release in acidic pH compared with alkaline pH. It was interesting to note that pelletized budesonide nanoparticles released the drug throughout the GIT in a sustained fashion, and had long-lasting anti-inflammatory effects while rapid relapse was observed for those treated with conventional budesonide pellets. It seems that there is a synergistic effect of nanoformulation of budesonide and the encapsulation of pelletized nanoparticles in a proper coating system for colon delivery that could result in a significant and long-lasting anti-inflammatory effect.

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Nanoparticles for oral delivery: targeted therapy for inflammatory bowel disease

Abstract: As a group of chronic and idiopathic gastrointestinal (GI) disorders, inflammatory bowel disease (IBD) is characterized by recurrent intestinal mucosal inflammation.

Cited by 34 publications

References 211 publications

Multiscale Magnetic Hydrogel Robot with a Core–Shell Structure for Active Targeted Delivery

Multiscale Magnetic Hydrogel Robot with a Core–Shell Structure for Active Targeted Delivery

Plant-derived extracellular vesicles (PDEVs) in nanomedicine for human disease and therapeutic modalities

Preparation and Characterization of a Novel Multiparticulate Dosage Form Carrying Budesonide-Loaded Chitosan Nanoparticles to Enhance the Efficiency of Pellets in the Colon

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