Plant-derived extracellular vesicles (PDEVs) in nanomedicine for human disease and therapeutic modalities

Abstract

Background The past few years have witnessed a significant increase in research related to plant-derived extracellular vesicles (PDEVs) in biological and medical applications. Using biochemical technologies, multiple independent groups have demonstrated the important roles of PDEVs as potential mediators involved in cell-cell communication and the exchange of bio-information between species. Recently, several contents have been well identified in PDEVs, including nucleic acids, proteins, lipids, and other active substances. These cargoes carried by PDEVs could be transferred into recipient cells and remarkably influence their biological behaviors associated with human diseases, such as cancers and inflammatory diseases. Main body of the abstract This review summarizes the latest updates regarding PDEVs and focuses on its important role in nanomedicine applications, as well as the potential of PDEVs as drug delivery strategies to develop diagnostic and therapeutic agents for the clinical management of diseases, especially like cancers. Conclusion Considering its unique advantages, especially high stability, intrinsic bioactivity and easy absorption, further elaboration on molecular mechanisms and biological factors driving the function of PDEVs will provide new horizons for the treatment of human disease.

Kuwanon H Inhibits Melanoma Growth through Cytotoxic Endoplasmic Reticulum Stress and Impaired Autophagy Flux

“…12 Therefore, manipulating autophagy or ER stress could be a promising strategy to overcome drug resistance in cancer therapy, especially given that ER stress is a potent autophagy trigger. 13 Numerous plant-derived compounds and products have demonstrated significant potential in the prevention and treatment of various diseases, 14,15 including malignancies such as cancer. 16 Natural-derived compounds and products are of significant interest in cancer chemoprevention due to their minimal side effects and abundant sources.…”

“…Numerous plant-derived compounds and products have demonstrated significant potential in the prevention and treatment of various diseases, , including malignancies such as cancer . Natural-derived compounds and products are of significant interest in cancer chemoprevention due to their minimal side effects and abundant sources.…”

Plant exosomes: A natural medicine for oral cancer

“…7 PDExo is a potential therapeutic tool for oral cancer. 8 Sources of PDExo are fruit, vegetables, and different parts of plants. 7 PDExo offers an alternative, addressing limitations and expanding sources, marking a promising avenue in exosome research in oral oncology.…”

“…It is an effective green drug delivery approach. 8,9 This therapeutic source is more effective due to its biocompatibility, less immune reactivity, low toxicity, and ability to cross biological barriers. 9 It is effective compared to the stem cell-derived exosome-based therapeutic approach (because stem cell-derived exosomes promote cancer or inhibit cancer).…”

“…7 Plant-derived exosomes (PDExo) show a significant role in cancer healing. 8 Compared to other sources, it is toxicologically safer. 7 PDExo is a potential therapeutic tool for oral cancer.…”