Extracellular vesicles in skin health, diseases, and aging

Wang, Juan; Yuan, Siqi; Tu, Yidong; Lv, Zhi; Cheng, Hua; Ding, Xiaolei

doi:10.1002/inmd.20240011

Interdisciplinary Medicine

2024

DOI: 10.1002/inmd.20240011

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Extracellular vesicles in skin health, diseases, and aging

Juan Wang,

Siqi Yuan,

Yidong Tu

et al.

Abstract: The skin interfaces with the external environment, acting as both a physical barrier and an immunologic defense. The dynamic interactions between various cell types are essential for skin homeostasis and function. Emerging research has unveiled the significant role of extracellular vesicles (EVs) as key mediators of cell communication in regulating many aspects of skin physiological and pathological processes. In this review, we provide an overview of recent advances in understanding the physiological and path… Show more

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Cited by 2 publications

References 192 publications

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Lubricin‐Inspired Nanozymes Reconstruct Cartilage Lubrication System with an “In‐Out” Strategy

Du,

Chen,

Liu

et al. 2024

Small Methods

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Lubricin, secreted primarily by chondrocytes, plays a critical role in maintaining the function of the cartilage lubrication system. However, both external factors such as friction and internal factors like oxidative stress can disrupt this system, leading to osteoarthritis. Inspired by lubricin, a lubricating nanozyme, that is, Poly‐2‐acrylamide‐2‐methylpropanesulfonic acid sodium salt‐grafted aminofullerene, is developed to restore the cartilage lubrication system using an “In‐Out” strategy. The “Out” aspect involves reducing friction through a combination of hydration lubrication and ball‐bearing lubrication. Simultaneously, the “In” aspect aims to mitigate oxidative stress by reducing free radical, increasing autophagy, and improving the mitochondrial respiratory chain. This results in reduced chondrocyte senescence and increased lubricin production, enhancing the natural lubrication ability of cartilage. Transcriptome sequencing and Western blot results demonstrate that it enhances the functionality of mitochondrial respiratory chain complexes I, III, and V, thereby improving mitochondrial function in chondrocytes. In vitro and in vivo experiments show that the lubricating nanozymes reduce cartilage wear, improve chondrocyte senescence, and mitigate oxidative stress damage, thereby mitigating the progression of osteoarthritis. These findings provide novel insights into treating diseases associated with oxidative stress and frictional damage, such as osteoarthritis, and set the stage for future research and development of therapeutic interventions.

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Lubricin‐Inspired Nanozymes Reconstruct Cartilage Lubrication System with an “In‐Out” Strategy

Du,

Chen,

Liu

et al. 2024

Small Methods

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Surgical outcomes of sacrospinous hysteropexy and hysteropreservation for pelvic organ prolapse: a systematic review of randomized controlled trials

Xiao,

Yu,

Yin

et al. 2024

Front. Med.

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ObjectiveIn several randomized controlled trials (RCTs), sacrospinous hysteropexy and other forms of hysteropreservation have been compared. Nevertheless, there is no definitively best treatment. This study summarized RCT evidence for various uterine preservation surgical procedures.MethodsFrom each database inception to August 2023, we searched PubMed, Embase, Cochrane Library, and Web of Science for eligible RCTs. A comparison was made between sacrospinous hysteropexy and other hysteropreservation, including vaginal and abdominal surgery. For categorical and continuous variables, relative risks (RRs) and mean differences (MDs) were calculated using random-effects models.ResultsWe reviewed a total 1,398 studies and ultimately included five RCTs that met all inclusion criteria. These five studies included a total of 1,372 uterine POP cases all of whom received transvaginal surgery and had a follow-up period for assessment of recurrence from 12 months to 5 years. There were no significant differences between sacrospinous hysteropexy and other hysteropreservation for the incidences of recurrence (RR,1.24; 95% CI, 0.58 to 2.63; p = 0.58) or hematoma (RR,0.70; 95% CI, 0.17 to 2.92; p = 0.62). Moreover, neither sacrospinous hysteropexy nor hysteropreservation had any significant effect on the risk of mesh exposure (RR,0.34; 95% CI, 0.03 to 4.31; p = 0.41), dyspareunia (RR,0.45; 95% CI, 0.13 to1.6; p = 0.22), urinary tract infection (RR,0.66; 95% CI, 0.38 to 1.15; p = 0.15), bothersome bulge symptoms (RR,0.03; 95% CI, −0.02 to 0.08; p = 0.24), operative time (MD, −4.53; 95% CI, −12.08 to 3.01; p = 0.24), and blood loss (MD, −25.69; 95% CI, −62.28 to 10.91; p = 0.17). However, sacrospinous hysteropexy was associated with a lower probability of pain (RR,4.8; 95% CI, 0.79 to 29.26; p = 0.09) compared with other hysteropreservation.ConclusionThere was no difference between sacrospinous hysteropexy and hysteropreservation in terms of recurrence, hematoma, mesh exposure, dyspareunia, urinary tract infection, bothersome bulge symptoms, operative time, pain, and blood loss.Systematic Review RegistrationPROSPERO [CRD42023470025].

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Extracellular vesicles in skin health, diseases, and aging

Cited by 2 publications

References 192 publications

Lubricin‐Inspired Nanozymes Reconstruct Cartilage Lubrication System with an “In‐Out” Strategy

Lubricin‐Inspired Nanozymes Reconstruct Cartilage Lubrication System with an “In‐Out” Strategy

Surgical outcomes of sacrospinous hysteropexy and hysteropreservation for pelvic organ prolapse: a systematic review of randomized controlled trials

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