Nanoparticles: Emerging carriers for drug delivery

Mudshinge, Sagar R.; Deore, Amol Bhalchandra; Patil, Sachin; Bhalgat, Chetan M.

doi:10.1016/j.jsps.2011.04.001

Cited by 442 publications

(205 citation statements)

References 153 publications

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“…Some targeted drugs have also been developed as a specific treatment for cancer chemotherapy. 23 However, it is not enough to improve the specificity of chemotherapy drugs alone. On the one hand, because of the presence of several biological barriers, such as the mononuclear phagocyte system, 24 blood-brain barrier (BBB), 25,26 kidney filtration, 27,28 and so on, chemotherapy drugs have difficulty in reaching the tumor site and may not reach the effective concentration in some tissues.…”

Section: Introductionmentioning

confidence: 99%

Effects of major parameters of nanoparticles on their physical and chemical properties and recent application of nanodrug delivery system in targeted chemotherapy

Zhang¹,

Tang²,

Liu³

et al. 2017

IJN

128

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Chemotherapy is still one of the main cancer therapy treatments, but the curative effect of chemotherapy is relatively low, as such the development of a new cancer treatment is highly desirable. The gradual maturation of nanotechnology provides an innovative perspective not only for cancer therapy but also for many other applications. There are a diverse variety of nanoparticles available, and choosing the appropriate carriers according to the demand is the key issue. The performance of nanoparticles is affected by many parameters, mainly size, shape, surface charge, and toxicity. Using nanoparticles as the carriers to realize passive targeting and active targeting can improve the efficacy of chemotherapy drugs significantly, reduce the mortality rate of cancer patients, and improve the quality of life of patients. In recent years, there has been extensive research on nanocarriers. In this review, the effects of several major parameters of nanoparticles on their physical and chemical properties are reviewed, and then the recent progress in the application of several commonly used nanoparticles is presented.

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Section: Introductionmentioning

confidence: 99%

Effects of major parameters of nanoparticles on their physical and chemical properties and recent application of nanodrug delivery system in targeted chemotherapy

Zhang¹,

Tang²,

Liu³

et al. 2017

IJN

128

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“…The release of nanoparticles from formulations is governed by the separation of nanoparticles from the polymer matrix and their diffusion from the matrix. 27 Percentage of drug released from different films [F5, F6, F7 and control (drug incorporated films)]…”

Section: Ex-vivo Permeation Studiesmentioning

confidence: 99%

Mucoadhesive Film Embedded with Acyclovir Loaded Biopolymeric Nanoparticles: In vitro Studies

Nair¹,

Al-ghannam²,

Al‐Dhubiab³

et al. 2017

JYP

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Objective: The efficiency of acyclovir, a potent antiviral agent, is mainly limited by its low permeability.The purpose of this investigation was to formulate and assess nanoparticle impregnated buccal films to improve acyclovir permeability and thereby enhance bioavailability. Methods: Acyclovir was incorporated into the polymeric materials and formulated as nanoparticles. The prepared nanoparticles were then loaded into various films (F5-F7) prepared with varying quantities of hydroxyethyl cellulose and Eudragit RL 100. The prepared films were evaluated for physico-mechanical characters, mucoadhesion, swelling, in vitro acyclovir release and ex vivo diffusion. Results: The films so prepared showed adequate mucoadhesive strength and excellent physico-mechanical properties. Rapid hydration of films (>35%) were observed in 15 min, followed by a relatively slower phase of hydration which continued till 60 min. In vitro release profile exhibited biphasic pattern, while the rate of acyclovir release was higher with film F7. Prepared films exhibited either first order (F5, control) or Higuchi model (F6, F7) kinetics. The enhancement in acyclovir permeation in F5, F6 and F7 loaded films were 2.2, 4.1 and 6.7 folds, respectively, when compared to control. Conclusion: This study concludes that the drug loaded nanoparticles impregnated buccal film could be an alternative approach to enhance the oral bioavailability of acyclovir, and need to be proved in vivo.

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“…Superparamagnetism is common in sufficiently small ferromagnetic or ferrimagnetic nanoparticles that have a single magnetic domain. These molecules are attracted to a magnetic field, but after the removal of this field they do not retain residual magnetism [31][32][33].…”

Section: Mechanism Of Drug Deliverymentioning

confidence: 99%

Superparamagnetic calcium ferrite nanoparticles synthesized using a simple sol-gel method for targeted drug delivery

Sulaiman

Ghazali

Majlis

et al. 2015

BME

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Abstract. The calcium ferrite nano-particles (CaFe 2 O 4 NPs) were synthesized using a sol-gel method for targeted drug delivery application. The proposed nano-particles were initially prepared by mixing calcium and iron nitrates that were added with citric acid in order to prevent agglomeration and subsequently calcined at a temperature of 550ÛC to obtain small particle size. The prepared nanoparticles were characterized by using an XRD (X-ray diffraction), which revealed the configuration of orthorhombic structures of the CaFe 2 O 4 nano-particles. A crystallite size of ~13.59 nm was obtained using a Scherer's formula. Magnetic analysis using a VSM (Vibrating Sample Magnetometer analysis), revealed that the synthesized particles exhibited super-paramagnetic behavior having magnetization saturation of approximately 88.3emu/g. Detailed observation via the scanning electron microscopy (SEM) showed the calcium ferrite nano-particles were spherical in shape.

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Nanoparticles: Emerging carriers for drug delivery

Cited by 442 publications

References 153 publications

Effects of major parameters of nanoparticles on their physical and chemical properties and recent application of nanodrug delivery system in targeted chemotherapy

Effects of major parameters of nanoparticles on their physical and chemical properties and recent application of nanodrug delivery system in targeted chemotherapy

Mucoadhesive Film Embedded with Acyclovir Loaded Biopolymeric Nanoparticles: In vitro Studies

Superparamagnetic calcium ferrite nanoparticles synthesized using a simple sol-gel method for targeted drug delivery

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