Nanoparticles as Delivery Systems in Cancer Therapy

Carvalho, Andreia; Fernandes, Alexandra R.; Baptista, Pedro V.

doi:10.1016/b978-0-12-814029-1.00010-7

Cited by 27 publications

(21 citation statements)

References 188 publications

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“…The exponential increase of the research and publications related to nanomedicine in the last decades is linked to the improvements observed in the field of medicine related to cancer therapy ( Figure 1) [8][9][10]. The importance of research in cancer diseases has been also acknowledged by Nature editorial group that only recently published Nature Cancer journal focusing on exploration of leading edge solutions to cancer.…”

Section: Introductionmentioning

confidence: 99%

Encapsulation for Cancer Therapy

et al. 2020

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The current rapid advancement of numerous nanotechnology tools is being employed in treatment of many terminal diseases such as cancer. Nanocapsules (NCs) containing an anti-cancer drug offer a very promising alternative to conventional treatments, mostly due to their targeted delivery and precise action, and thereby they can be used in distinct applications: as biosensors or in medical imaging, allowing for cancer detection as well as agents/carriers in targeted drug delivery. The possibility of using different systems—inorganic nanoparticles, dendrimers, proteins, polymeric micelles, liposomes, carbon nanotubes (CNTs), quantum dots (QDs), biopolymeric nanoparticles and their combinations—offers multiple benefits to early cancer detection as well as controlled drug delivery to specific locations. This review focused on the key and recent progress in the encapsulation of anticancer drugs that include methods of preparation, drug loading and drug release mechanism on the presented nanosystems. Furthermore, the future directions in applications of various nanoparticles are highlighted.

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Section: Introductionmentioning

confidence: 99%

Encapsulation for Cancer Therapy

et al. 2020

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“…(1) Biomedical Study. Dendrimers are widely used in the biomedical field where they are used as analogs to proteins, enzymes, and viruses where they are primarily used to focus the target cells and conjugated to the host dendrimeric cells, for example, poly(amidoamine) dendrimer [7].…”

Section: Medical Applicationsmentioning

confidence: 99%

“…Dendrimeric formulations which are used in the hydrogels are cross-linked networks that increase the volume in the aqueous solution. By the addition of polyethylene glycol groups, they are widely used in cartilage tissue production and for sealing the ophthalmic injuries and targeted delivery [7].…”

Section: Medical Applicationsmentioning

confidence: 99%

Dendrimers: A New Race of Pharmaceutical Nanocarriers

Moteriya

Saharan

Verma

et al. 2021

BioMed Research International

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Dendrimers are nanosized, symmetrical molecules in which a small atom or group of atoms is surrounded by the symmetric branches known as dendrons. The structure of dendrimers possesses the greatest impact on their physical and chemical properties. They grow outwards from the core-shell which further reacts with monomers having one reactive or two dormant molecules. Dendrimers’ unique characteristics such as hyperbranching, well-defined spherical structure, and high compatibility with the biological systems are responsible for their wide range of applications including medical and biomedical areas. Particularly, the dendrimers’ three-dimensional structure can incorporate a wide variety of drugs to form biologically active drug conjugates. In this review, we focus on the synthesis, mechanism of drug encapsulations in dendrimers, and their wide applications in drug delivery.

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“…Dendrimers are three‐dimensional and hyperbranched structures, which are synthesized from branched monomers (Figure 1C). 43 They exhibit very low polydispersity index, which is favorable in drug delivery applications 44 . Dendrimers are composed of many generations radially around a core.…”

Section: Polymeric Carriers Structuresmentioning

confidence: 99%

Polymeric nanocarriers in targeted drug delivery systems: A review

Abasian

Ghanavati

Rahebi

et al. 2020

Polymers for Advanced Techs

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Today's medicine mainly relies on conventional means of therapeutics delivery to the human body, such as tablets, capsules, syrups, and injectable drugs. Utilizing such techniques are associated with a number of drawbacks including the need of high drug dosage, causing transient drug concentration changes in the patient's body, poor solubility, poor bioavailability, drug degradation, and interaction with the biological environment (enzymes and proteins). To address these issues, nanotechnology-based novel drug delivery methods are proposed. Among the plethora of novel drug delivery techniques, the use of polymeric nanocarriers is shown to be promising. In fact, they focus on three main questions: first, where should a drug be released? Second, when should the drug be released? And finally, how should the drug be released? In this review, we are confined to explaining some concepts regarding to polymeric nanocarriers. First, different kinds of polymeric nanocarriers have been explained, in terms of their structures and properties. Second, different fabrication methods, for each one, have been elaborated. Finally, a handful of works carried out have been reviewed for their special structure, their kind of polymers which is used, and the drug which is encapsulated.

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Nanoparticles as Delivery Systems in Cancer Therapy

Cited by 27 publications

References 188 publications

Encapsulation for Cancer Therapy

Encapsulation for Cancer Therapy

Dendrimers: A New Race of Pharmaceutical Nanocarriers

Polymeric nanocarriers in targeted drug delivery systems: A review

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