Dendrimers are nanosized, symmetrical molecules in which a small atom or group of atoms is surrounded by the symmetric branches known as dendrons. The structure of dendrimers possesses the greatest impact on their physical and chemical properties. They grow outwards from the core-shell which further reacts with monomers having one reactive or two dormant molecules. Dendrimers’ unique characteristics such as hyperbranching, well-defined spherical structure, and high compatibility with the biological systems are responsible for their wide range of applications including medical and biomedical areas. Particularly, the dendrimers’ three-dimensional structure can incorporate a wide variety of drugs to form biologically active drug conjugates. In this review, we focus on the synthesis, mechanism of drug encapsulations in dendrimers, and their wide applications in drug delivery.
Corona virus disease (COVID-19) is caused by SARS-COV2 and it represents global public health concern and World Health Organization (WHO) declares public health emergency. Special attention is focused to reduce community transmission of COVID-19 have been implemented to control the current outbreak. COVID-19 develops intestinal symptoms like diarrhea, while low percentage of MERS-CoV or SARS-CoV patients had diarrhea. As the race to find the treatments to cure COVID-19 accelerates, the WHO announced to compare treatment strategies in a streamlined clinical trial design that doctors around the world can join. There is no specific treatment for disease caused byCOVID-19. However, many of the clinical symptoms can be treated and therefore treatment based on the patient's clinical condition. Identification of novel chemotherapeutic drugs for treating COVID-19 infections is urgently warranted.
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