Nanoparticle–membrane interactions

Contini, Claudia; Schneemilch, M.; Gaisford, Simon; Quirke, N.

doi:10.1080/17458080.2017.1413253

Cited by 144 publications

(110 citation statements)

References 98 publications

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“…19,20 Unfortunately, there are relatively few experimental data for the adhesion strength that would allow us to better understand these toxicity pathways. 14 The only direct measurement of the adhesion strength of lipid bilayers on silica surfaces, as far as we aware, was performed by Anderson et al 15 using a surface force apparatus. 1,2-dimyristoyl-snglycero-3-phosphocholine (DMPC) supported lipid bilayers (SLBs), formed by fusion of vesicles or Langmuir-Blodgett deposition, were contacted by electron-deposited amorphous silica surfaces in phosphate-buffered saline solution.…”

Section: Introductionmentioning

confidence: 99%

Free energy of adhesion of lipid bilayers on silica surfaces

Schneemilch

Quirke

2018

The Journal of Chemical Physics

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The free energy of adhesion per unit area (hereafter referred to as the adhesion strength) of lipid arrays on surfaces is a key parameter that determines the nature of the interaction between materials and biological systems. Here we report classical molecular simulations of water and 1,2-dimyristoylsn-glycero-3-phosphocholine (DMPC) lipid bilayers at model silica surfaces with a range of silanol densities and structures. We employ a novel technique that enables us to estimate the adhesion strength of supported lipid bilayers in the presence of water. We find that silanols on the silica surface form hydrogen bonds with water molecules and that the water immersion enthalpy for all surfaces varies linearly with the surface density of these hydrogen bonds. The adhesion strength of lipid bilayers is a linear function of the surface density of hydrogen bonds formed between silanols and the lipid molecules on crystalline surfaces. Approximately 20% of isolated silanols form such bonds but more than 99% of mutually interacting geminal silanols do not engage in hydrogen bonding with water. On amorphous silica, the bilayer displays much stronger adhesion than expected from the crystalline surface data. We discuss the implications of these results for nanoparticle toxicity.

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Section: Introductionmentioning

confidence: 99%

Free energy of adhesion of lipid bilayers on silica surfaces

Schneemilch

Quirke

2018

The Journal of Chemical Physics

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“…Unlike in E. coli cells, the outer surface of S. aureus cells consists of a thick layer of peptidoglycan that stabilizes the cell and limits the cell‐nanoparticle interaction . In contrast, Gram‐negative bacterial cells possess a thin peptidoglycan layer covered by the outer membrane that easily loses its stability after treatment with nanoparticles . Interestingly, significantly higher antimicrobial activity of synthesized TMA‐AgNPs toward S. aureus and C. albicans was observed than in the case of commercially available samples of these nanostructures (Table ).…”

Section: Resultsmentioning

confidence: 99%

Production of antimicrobial silver nanoparticles modified by alkanethiol self‐assembled monolayers by direct current atmospheric pressure glow discharge generated in contact with a flowing liquid anode

Dzimitrowicz

Krychowiak-Maśnicka

Pohl

et al. 2019

Plasma Processes & Polymers

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Direct current atmospheric pressure glow discharge (dc‐APGD) generated in contact with a flowing liquid anode (FLA) is used for continuous synthesis of size‐defined silver nanoparticles (AgNPs) modified by a (11‐mercaptoundecyl)‐N,N,N‐trimethylammonium chloride (TMA) alkanethiol self‐assembled monolayer. The impact of the operating parameters (concentration of Ag(I) ions, solution flow rate, discharge current) on the size of TMA‐AgNPs is examined. Design of experiments along with response surface methodology reveals that it is possible to obtain size‐defined TMA‐AgNPs, the smallest being 1.21 ± 0.80 nm. Furthermore, the reactive species involved in formation of TMA‐AgNPs are identified using optical emission spectrometry. TMA‐AgNPs are characterized by several other experimental techniques, which confirm production of approximately spherical, well‐dispersed TMA‐AgNPs. Additionally, attenuated total reflection Fourier transform infrared spectroscopy and UV/Vis absorption spectrophotometry confirmed that the surface of Ag nanostructures is covered by TMA. TMA‐AgNPs display antimicrobial activity toward multiple human pathogens (Escherichia coli, Staphylococcus aureus, and Candida albicans) with minimal bactericidal concentrations or minimal fungicidal concentrations of 3.90 ± 0.15, 7.79 ± 0.30, and 3.90 ± 0.15 mg/L, respectively.

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“…There is some evidence that nanoparticle pass through cell membranes and interact with cellular structures, and then have a direct impact on cell viability. 24,25 Bendale et al 26 also have reported the cytotoxicity of platinum nanoparticles in ovarian, lung and pancreatic cancer cell lines. In contrast, no significant cytotoxic effect was observed in the normal human peripheral blood mononucleocyte.…”

Section: Discussionmentioning

confidence: 99%

“…Based on in vivo results, we performed in vitro experiments using HSC‐3‐M3 cells to investigate the tumor growth inhibitory effect of PtNCP beads. There is some evidence that nanoparticle pass through cell membranes and interact with cellular structures, and then have a direct impact on cell viability . Bendale et al also have reported the cytotoxicity of platinum nanoparticles in ovarian, lung and pancreatic cancer cell lines.…”

Section: Discussionmentioning

confidence: 99%

Anticancer effect of novel platinum nanocomposite beads on oral squamous cell carcinoma cells

et al. 2019

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Nanoparticles are used in industry and medicine, because of their physiochemical properties, such as size, charge, large surface area and surface reactivity. Recently, metal nanoparticles were reported to show cell toxicity on cancer cells. In this study, we focused novel platinum nanoparticles‐conjugated latex beads (P2VPs), platinum nanocomposite (PtNCP) beads, and investigated the possibility to incorporate novel anti‐cancer effect of these combined nanoparticles. Oral squamous cell carcinoma cell lines, HSC‐3‐M3 cells were injected subcutaneously into the back of nude mice to produce a xenograft model. PtNCP beads were injected locally and examined by measuring tumor volume and comparing pathological histology. PtNCP beads treatment suppressed tumor growth and identified increasing pathological necrotic areas, in vivo. PtNCP beads inhibited the cell viability of HSC‐3‐M3 cells in dose‐dependent manner and induced the cytotoxicity with extracellular LDH value, in vitro. Furthermore, SEM images were morphologically observed in PtNCP beads‐treated HSC‐3‐M3 cells. The aggregation of the PtNCP beads on the cell membrane, the destructions of the cell membrane and globular structures were observed in the SEM image. Our results indicated that a potential anti‐cancer effect of the PtNCP beads, suggesting the possibility as a therapeutic tool for cancer cell‐targeted therapy. © 2019 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater 107B: 2281–2287, 2019.

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Nanoparticle–membrane interactions

Cited by 144 publications

References 98 publications

Free energy of adhesion of lipid bilayers on silica surfaces

Free energy of adhesion of lipid bilayers on silica surfaces

Production of antimicrobial silver nanoparticles modified by alkanethiol self‐assembled monolayers by direct current atmospheric pressure glow discharge generated in contact with a flowing liquid anode

Anticancer effect of novel platinum nanocomposite beads on oral squamous cell carcinoma cells

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