Free energy of adhesion of lipid bilayers on silica surfaces

Schneemilch, M.; Quirke, N.

doi:10.1063/1.5028557

Cited by 19 publications

(23 citation statements)

References 33 publications

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“…Note that the critical diameter changes depending on the nature of the nanoparticle surface. Molecular simulations 30,31 have shown that for neutral crystalline silica surfaces the critical diameter as defined above, obtained from predictions of W; is~16 nm while for amorphous silica is~10 nm. For AuNPs the critical diameter is much smaller (~4 nm) based on the experimental data/simulation prediction of W = 42 mN m −1 32 for a bare gold surface.…”

Section: Resultsmentioning

confidence: 94%

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Size dependency of gold nanoparticles interacting with model membranes

et al. 2020

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The rapid development of nanotechnology has led to an increase in the number and variety of engineered nanomaterials in the environment. Gold nanoparticles (AuNPs) are an example of a commonly studied nanomaterial whose highly tailorable properties have generated significant interest through a wide range of research fields. In the present work, we characterise the AuNP-lipid membrane interaction by coupling qualitative data with quantitative measurements of the enthalpy change of interaction. We investigate the interactions between citrate-stabilised AuNPs ranging from 5 to 60 nm in diameter and large unilamellar vesicles acting as a model membrane system. Our results reveal the existence of two critical AuNP diameters which determine their fate when in contact with a lipid membrane. The results provide new insights into the size dependent interaction between AuNPs and lipid bilayers which is of direct relevance to nanotoxicology and to the design of NP vectors.

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Section: Resultsmentioning

confidence: 94%

“…where Àk w is the simulated absorption strength on a flat surface [30][31][32]34 , a is the wrapping diameter equal to the nominal radius plus 2 nm and m and κ SLB are adjustable constants fitted to coarse grained simulation data for w s SLB . This approach gives a critical diameter for adhesion for AuNPs equal to zero.…”

Section: Resultsmentioning

confidence: 99%

Size dependency of gold nanoparticles interacting with model membranes

et al. 2020

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“…We have used this method to calculate adhesion strengths for DMPC bilayers on planar surfaces of gold 29 , silica 30 , and titania 31 ( see table 1) as well as mixed lipid membranes with and without cholesterol for gold.…”

Section: Adhesion Strengthmentioning

confidence: 99%

Predicting Nanoparticle Uptake by Biological Membranes: Theory and Simulation

Schneemilch¹,

Quirke

2020

Preprint

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We describe a new approach which predicts the level of internalisation or complete wrapping of nanoparticles by liposomes in solution. It is based on a generalisation of elastic theory to nanoscale particles with physical property data obtained from atomistic and coarse-grained simulations. We apply this approach to determine the maximum number of nanoparticles of a given type that can be internalised by a given liposome and give examples of how our approach might be used to identify and/or design nanoparticles with different uptakes: New data that could be correlated with nanoparticle toxicity experiments . We briefly discuss the possibility of designing nanoscale separations process.

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“…The results of the adhesion simulations are recorded in Table 1 , data taken from previously published work for DMPC on gold 29 , silica 30 , and titania 31 .By far the greatest adhesion strength was recorded on the gold surface. For this material a reliable experimental value has been determined from chronocoulometry measurements with a gold electrode 34 .…”

Section: Adhesion Strengthmentioning

confidence: 99%