Altering the bioactivity of aqueous solutions via serial dilutions is important for toxicology, medicine and wastewater treatment. Extensive research has shown that serially diluting aqueous solutions beyond a threshold concentration, combined with vigorous shaking after each dilution step, has several notable effects. (a) The solutes may serve as substrates, which facilitate association of water molecules (10 -5 and 10 -7 m sized associates). (b) The associates and the bioactivity of these liquids persist when these fluids are diluted below 10 -24 mol/liter. (c) The associates and the bioactivity of these liquids disappear when such ultra-diluted fluids are screened from ambient electromagnetic radiation. (d) The structural and physicochemical properties of these liquids are explainable within the context of quantum electrodynamics (QED). Hitherto, relations between the physicochemical properties of these liquids and their substrates have not been unveiled. There are no reports of statistically significant data that reflect physicochemical aspects of these liquids attributable to specific characteristics of substrates. Moreover, the aforementioned relations have not been theoretically derived. In this study, the relations are ana-lyzed within the context of QED. The analyses have helped elucidate the challenge of observing the impact of the substrate on the associates. The analyses also indicate that measuring the quantum Hall effect of these liquids holds the promise of unveiling the aforementioned relations.