Nanoparticle Characterisation of Traditional Homeopathically Manufactured Cuprum metallicum and Gelsemium sempervirens Medicines and Controls

Wassenhoven, Michel Van; Goyens, Martine; Capieaux, Etienne; Devos, Philippe; Dorfman, Pierre

doi:10.1055/s-0038-1676304

Cited by 10 publications

(9 citation statements)

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“…From the size distribution by intensity particles prepared from solid sample in distilled water and those prepared from extract in ethanol 99,8% -distilled water before and after succussion, it appears that, the size of particles in all samples is in the range of micro-nanoscale in this research. Similar results have been shown by others as well [30].…”

Section: Discussionsupporting

confidence: 92%

Micro-nano particulate compositions of Hypericum perforatum L in ultra high diluted succussed solution medicinal products

Kalliantas¹,

Kallianta

Kordatos³

et al. 2021

Heliyon

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The fact that many patients all over the world use homeopathic ultra high diluted succussed medicinal products, makes very interesting an explanation about the structure of them since until now only unconfirmed hypotheses are made. The present study focuses on the still unanswered questions about what happens with the chemical composition and the physicochemical properties of these products using Hypericum Perforatum L as a representative paradigm. All samples were prepared according to manufacturing procedures described mainly in S. Hahnemann's "Organon" and were examined by SEM, XRD, FTIR, DLS micro Mastersizer, DLS nano Zetasizer, UV-Vis and TEM. Measurements of electrical conductivity and pH were effectuated by the appropriate devices. During trituration of source material in alpha-lactose monohydrate some functional chemical groups present in source material disappeared and some others new ones came in view at the end of the process. A differentiation upon physicochemical properties between the source material and final triturating product was viewed, as well as micro-nanoparticles in colloidal form in all potencies derived trituration or extraction origin were present. The findings showed that the whole preparation process leads to the creation of micro nanoparticles something that for solid origin these products are created by trituration and for extract origin products these nanoparticles exist from the beginning.

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Section: Discussionsupporting

confidence: 92%

Micro-nano particulate compositions of Hypericum perforatum L in ultra high diluted succussed solution medicinal products

Kalliantas¹,

Kallianta

Kordatos³

et al. 2021

Heliyon

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“…Thus, the presence of source-drug in extremely low level as at nanoscale is very likely in commercially-made market-purchased medicines. Using self-made samples in laboratory, Van Wassenhoven et al could not validate the findings of Chikramane et al 75…”

Section: How Ultra-high Dilutions May Work As Nanomedicinesmentioning

confidence: 91%

“…Thus, the presence of source-drug in extremely low level as at nanoscale is very likely in commercially-made market-purchased medicines. Using selfmade samples in laboratory, Van Wassenhoven et al could not validate the findings of Chikramane et al 75 As Van Wassenhoven et al could not detect the source-drug even at 4C potency level, where such a presence is expected, this seems to question the sensitivity of the tools they used (Bellare, personal communication, March 2, 2021). Bellare notes that Van Wassenhoven, et al used dynamic light scattering, SEM with EDX, which are nano-analysis techniques that have limited capability to detect ultrahigh dilution samples.…”

Section: How Ultra-high Dilutions May Work As Nanomedicinesmentioning

confidence: 97%

Exploring Possible Mechanisms of Hormesis and Homeopathy in the Light of Nanopharmacology and Ultra-High Dilutions

Ullman¹

2021

Dose-Response

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Serially diluted succussed solutions of a suitable drug/toxic substance can exhibit physicochemical and biological properties even far beyond Avogadro’s limit defying conventional wisdom. They can show hormesis, and homeopathy uses them as medicines. Many studies confirm that they can have an impact on gene expression different than controls. Water in the exclusion zone phase can have memory but for a short period. However, the nanoparticle as the physical substrate can hold information. Nanoparticle and exclusion zone duo as nanoparticle-exclusion zone shell can provide a prolonged memory. The Nanoparticle-Exclusion Zone Shell Model may be an important step toward explaining the nature and bioactivity of serially diluted succussed solutions used as homeopathic medicines. This model may also provide insight into the workings of hormesis. Hormesis is the primary phenomenon through which homeopathic phenomenon may have evolved exhibiting the principle of similars. Hahnemann exploited it to establish homeopathy. The nanoparticle-exclusion zone shells present in the remedy, selected on the principle of similars, can be patient-specific nanoparticles in a symptom syndrome-specific manner. They can carry the drug-specific information for safer clinical applications in an amplified form for high yielding. It suggests homeopathy is a type of nanopharmacology.

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“…18 Other research groups, including Van Wassenhoven et al , investigated the presence of metal NPs in homeopathic dilutions that use water as solvent, but did not confirm the same findings. 19…”

Section: Introductionmentioning

confidence: 99%

Pro-Inflammatory Cytokines at Ultra-Low Dose Exert Anti-Inflammatory Effect In Vitro: A Possible Mode of Action Involving Sub-Micron Particles?

Floris¹,

Rose²,

Rojas

et al. 2020

Dose-Response

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Tumor necrosis factor-α (TNF-α) and interleukin-1β (IL-1β) are pro-inflammatory cytokines involved in acute and chronic inflammatory diseases. Indeed, immunotherapy blocking these 2 cytokines has been developed. Micro-immunotherapy (MI) also uses ultra-low doses (ULD) of pro-inflammatory cytokines, impregnated on lactose-sucrose pillules, to counteract their overexpression. The study has been conducted with 2 objectives: examine the anti-inflammatory effect in vitro and the capacity of 2 unitary medicines, TNF-α (27 CH) and IL-1β (27 CH), to reduce the secretion of TNF-α in human primary monocytes and THP-1 cells differentiated with phorbol-12-myristate-13-acetate, after lipopolysaccharide (LPS) exposure; then, investigate the presence of particles possibly containing starting materials using tunable resistive pulse sensing technique. The results show that the unitary medicines, tested at 3 pillules concentrations (5.5, 11 and 22 mM), have reduced the secretion of TNF-α in both models by about 10−20% vs. vehicle control, depending on concentration. In this exploratory study, particles (150−1000 nm) have been detected in MI ULD-impregnated pillules and a hypothesis for MI medicines mode of action has been proposed. Conscious that more evaluations are necessary, authors are cautious in the conclusions because the findings described in the study are still limited, and future investigations may lead to different hypothesis.

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Nanoparticle Characterisation of Traditional Homeopathically Manufactured Cuprum metallicum and Gelsemium sempervirens Medicines and Controls

Cited by 10 publications

References 0 publications

Micro-nano particulate compositions of Hypericum perforatum L in ultra high diluted succussed solution medicinal products

Micro-nano particulate compositions of Hypericum perforatum L in ultra high diluted succussed solution medicinal products

Exploring Possible Mechanisms of Hormesis and Homeopathy in the Light of Nanopharmacology and Ultra-High Dilutions

Pro-Inflammatory Cytokines at Ultra-Low Dose Exert Anti-Inflammatory Effect In Vitro: A Possible Mode of Action Involving Sub-Micron Particles?

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