Nanomedical Platform for Drug Delivery

P, Naga Anusha

doi:10.4172/2157-7439.1000122

J Nanomed Nanotechnol

2011

DOI: 10.4172/2157-7439.1000122

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Nanomedical Platform for Drug Delivery

Naga Anusha P¹

Abstract: Nanoparticles hold tremendous potential as an effective drug delivery system. The developments in nanotechnology for drug delivery laid platform for nanomedicine. To achieve efficient drug delivery it is important to understand the interactions of nanomaterials with the biological environment. This rapidly growing field allows cross-disciplinary researchers the opportunity to design and develop multifunctional nanoparticles in the form of nanotubes that can target, diagnose, and treat diseases such as cancer. … Show more

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Cited by 5 publications

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Nanotechnology-based approaches in anticancer research

Jabir¹,

Tabrez²,

Ashraf³

et al. 2012

IJN

139

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Cancer is a highly complex disease to understand, because it entails multiple cellular physiological systems. The most common cancer treatments are restricted to chemotherapy, radiation and surgery. Moreover, the early recognition and treatment of cancer remains a technological bottleneck. There is an urgent need to develop new and innovative technologies that could help to delineate tumor margins, identify residual tumor cells and micrometastases, and determine whether a tumor has been completely removed or not. Nanotechnology has witnessed significant progress in the past few decades, and its effect is widespread nowadays in every field. Nanoparticles can be modified in numerous ways to prolong circulation, enhance drug localization, increase drug efficacy, and potentially decrease chances of multidrug resistance by the use of nanotechnology. Recently, research in the field of cancer nanotechnology has made remarkable advances. The present review summarizes the application of various nanotechnology-based approaches towards the diagnostics and therapeutics of cancer.

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Nanotechnology-based approaches in anticancer research

Jabir¹,

Tabrez²,

Ashraf³

et al. 2012

IJN

139

View full text Add to dashboard Cite

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3D Modeling of Epithelial Tumors—The Synergy between Materials Engineering, 3D Bioprinting, High-Content Imaging, and Nanotechnology

Trivedi

et al. 2021

IJMS

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The current statistics on cancer show that 90% of all human cancers originate from epithelial cells. Breast and prostate cancer are examples of common tumors of epithelial origin that would benefit from improved drug treatment strategies. About 90% of preclinically approved drugs fail in clinical trials, partially due to the use of too simplified in vitro models and a lack of mimicking the tumor microenvironment in drug efficacy testing. This review focuses on the origin and mechanism of epithelial cancers, followed by experimental models designed to recapitulate the epithelial cancer structure and microenvironment, such as 2D and 3D cell culture models and animal models. A specific focus is put on novel technologies for cell culture of spheroids, organoids, and 3D-printed tissue-like models utilizing biomaterials of natural or synthetic origins. Further emphasis is laid on high-content imaging technologies that are used in the field to visualize in vitro models and their morphology. The associated technological advancements and challenges are also discussed. Finally, the review gives an insight into the potential of exploiting nanotechnological approaches in epithelial cancer research both as tools in tumor modeling and how they can be utilized for the development of nanotherapeutics.

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Toxicity Issues Related to Biomedical Applications of Carbon Nanotubes

Jain¹,

Singh²,

Pillai³

2012

J Nanomedic Nanotechnol

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Carbon Nanotubes (CNTs) have emerged as a potential candidate for application in targeted drug delivery, cancer treatment, gene therapy and diagnostics. This review critically evaluates the biomedical potential of CNTs, and possible toxicological implications. Success of CNTs in other fields has not yet been translated to the biomedical field due to the lack of consistent data on toxicity, variation of toxicity due to characteristics such as shape and size along with the method of preparation, and limited control over functionalized CNTs behavior. Thus there is a lack of a predictable toxicity pattern of CNTs. This review summarizes the key findings on the toxicity of CNTs and the role of functionalization with hydrophilic moieties to reduce their toxicity, and increase cell penetrability for drug delivery and gene therapy applications. Caution is urged when handling this 'wonder material' but the immense potential for its commercial utilization and clinical trials infuses hope for future biomedical applications. Journal of Nanomedicine & Nanotechnology J o u rna l of N a n o m ed icine & N a n o te chnolo g y

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Nanomedical Platform for Drug Delivery

Cited by 5 publications

References 59 publications

Nanotechnology-based approaches in anticancer research

Nanotechnology-based approaches in anticancer research

3D Modeling of Epithelial Tumors—The Synergy between Materials Engineering, 3D Bioprinting, High-Content Imaging, and Nanotechnology

Toxicity Issues Related to Biomedical Applications of Carbon Nanotubes

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