Toxicity Issues Related to Biomedical Applications of Carbon Nanotubes

Jain, Sapna; Singh, Shree R.; Pillai, Shreekumar R.

doi:10.4172/2157-7439.1000140

Cited by 45 publications

(36 citation statements)

References 173 publications

(172 reference statements)

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“…In parallel, much attention is paid to research and development of techniques for directed modifications of CNTs to prevent cytotoxicity. Some of these approaches are summarized in the review by Jain et al [91]. …”

Section: Nanoencapsulation and Smart Delivery Systemsmentioning

confidence: 99%

Carbon nanomaterials: production, impact on plant development, agricultural and environmental applications

Zaytseva

Neumann

2016

Chem. Biol. Technol. Agric.

357

166

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During the relatively short time since the discovery of fullerenes in 1985, carbon nanotubes in 1991, and graphene in 2004, the unique properties of carbon-based nanomaterials have attracted great interest, which has promoted the development of methods for large-scale industrial production. The continuously increasing commercial use of engineered carbon-based nanomaterials includes technical, medical, environmental and agricultural applications. Regardless of the application field, this is also associated with an increasing trend of intentional or unintended release of carbon nanomaterials into the environment, where the effect on living organisms is still difficult to predict. This review describes the different types of carbon-based nanomaterials, major production techniques and important trends for agricultural and environmental applications. The current status of research regarding the impact of carbon nanomaterials on plant growth and development is summarized, also addressing the currently most relevant knowledge gaps.

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Section: Nanoencapsulation and Smart Delivery Systemsmentioning

confidence: 99%

Carbon nanomaterials: production, impact on plant development, agricultural and environmental applications

Zaytseva

Neumann

2016

Chem. Biol. Technol. Agric.

357

166

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“…The reviews published so far on nanoparticle toxicology provide information about toxicity of engineered nanoparticles to environmental microorganisms [20], titanium oxide nanoparticle toxicity [21], gold nanoparticle toxicity [21], risk management of inhaled nanoparticles [22], induced mitochondrial toxicity of silver nanoparticles [23] and single-wall carbon nanotube toxicity [24] and multi-wall carbon nanotube toxicity [25]. The published reviews are either too general or very specific (focusing on a single nanoparticle or toxicological effects on a particular organ) to explain the toxicity.…”

Section: Introductionmentioning

confidence: 99%

In vitro and in vivo toxicity assessment of nanoparticles

2017

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Nanotechnology has revolutionized gene therapy, diagnostics and environmental remediation. Their bulk production, uses and disposal have posed threat to the environment. With the appearance of these nanoparticles in the environment, their toxicity assessment is an immediate concern. This review is an attempt to summarize the major techniques used in cytotoxity determination. The review also presents a detailed and elaborative discussion on the toxicity imposed by different types of nanoparticles including carbon nanotubes, gold nanoparticles, silver nanoparticles, quantum dots, fullerenes, aluminium nanoparticles, zinc nanoparticles, iron nanoparticles, titanium nanoparticles and silica nanoparticles. It discusses the in vitro and in vivo toxological effects of nanoparticles on bacteria, microalgae, zebrafish, crustacean, fish, rat, mouse, pig, guinea pig, human cell lines and human. It also discusses toxological effects on organs such as liver, kidney, spleen, sperm, neural tissues, liver lysosomes, spleen macrophages, glioblastoma cells, hematoma cells and various mammalian cell lines. It provides information about the effects of nanoparticles on the gene-expression, growth and reproduction of the organisms.

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“…ROS may lead to harmful effects in cells such as apoptosis, DNA damage, amino acid oxidation, and inhibition of enzymes [35]. Proinflammatory cytokines and apoptosis are regulated by protein kinase and nuclear factor kappa B (NF-B) signalling pathways in response to oxidative stress [36]. Witzmann and MonteiroRiviere demonstrated that MWCNTs could initiate inflammatory responses.…”

Section: Carbon Nanotubes Potential Toxicity In Living Cells Includinmentioning

confidence: 99%

“…The controversy of CNTs with regard to their toxicity has slowed down the efforts for further innovation in their implementation especially in the clinical setting and hinders the CNT progress from the lab to clinical trials [36]. There is a lack of long-term toxicity research on CNTs as a higher proportion of toxicity studies conducted were for a short duration.…”

Section: Carbon Nanotubes Currently On the Market And Limitations Tomentioning

confidence: 99%

Diagnosis and Treatment of Neurological and Ischemic Disorders Employing Carbon Nanotube Technology

Komane

Choonara

Toit

et al. 2016

Journal of Nanomaterials

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Extensive research on carbon nanotubes has been conducted due to their excellent physicochemical properties. Based on their outstanding physicochemical properties, carbon nanotubes have the potential to be employed as theranostic tools for neurological pathologies such as Alzheimer’s disease and Parkinson’s disease including ischemic stroke diagnosis and treatment. Stroke is currently regarded as the third root cause of death and the leading source of immobility around the globe. The development and improvement of efficient and effective procedures for central nervous system disease diagnosis and treatment is necessitated. The main aim of this review is to discuss the application of nanotechnology, specifically carbon nanotubes, to the diagnosis and treatment of neurological disorders with an emphasis on ischemic stroke. Areas covered include the conventional current diagnosis and treatment of neurological disorders, as well as a critical review of the application of carbon nanotubes in the diagnosis and treatment of ischemic stroke, covering areas such as functionalization of carbon nanotubes and carbon nanotube-based biosensors. A broad perspective on carbon nanotube stimuli-responsiveness, carbon nanotube toxicity, and commercially available carbon nanotubes is provided. Potential future studies employing carbon nanotubes have been discussed, evaluating their extent of advancement in the diagnosis and treatment of neurological and ischemic disorders.

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Toxicity Issues Related to Biomedical Applications of Carbon Nanotubes

Cited by 45 publications

References 173 publications

Carbon nanomaterials: production, impact on plant development, agricultural and environmental applications

Carbon nanomaterials: production, impact on plant development, agricultural and environmental applications

In vitro and in vivo toxicity assessment of nanoparticles

Diagnosis and Treatment of Neurological and Ischemic Disorders Employing Carbon Nanotube Technology

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