Nanomechanical properties, SEM, and EDS microanalysis of dentin treated with 2.5% titanium tetrafluoride, before and after an erosive challenge

Basting, Roberta Tarkany; Leme, A.A.; Bridi, Enrico Coser; Amaral, Flávia Lucisano Botelho do; França, Fabiana Mantovani Gomes; Turssi, Cecília Pedroso; Bedran-Russo, Ana K.

doi:10.1002/jbm.b.33254

Cited by 25 publications

(37 citation statements)

References 35 publications

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“…The matrix, even though suggested to be removed prior to laboratorial analysis (17), may have been important to inhibit the progression of erosive lesions, especially when treated with TiF 4 . Some authors reported that TiF 4 produces a glaze on the dentin surface (6,18) and one of the strongest actual theories to explain this formation considers the direct interaction between titanium and the organic matrix (8).…”

Section: Discussionmentioning

confidence: 99%

“…Currently, fluoride compounds of polyvalent metal ions, especially titanium tetrafluoride (TiF 4 ), have been studied due to their unique interaction with the tooth structure, leading to the formation of an acid-resistant glaze-like layer capable of adhering strongly to the tooth surface (6). Among the existing theories to explain its action, one is that titanium is capable of reacting with the oxygen atoms of the phosphate groups of the dental tissue, forming stable titanium oxides (7) or organometallic complexes that can act as a diffusion barrier (8).…”

Section: Introductionmentioning

confidence: 99%

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The In Situ Effect of Titanium Tetrafluoride Gel on Erosion/Abrasion Progression in Human Dentin

et al. 2017

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Erosion incidence is increasing and its control is still a challenge in clinical practice. This study evaluated 4% TiF 4 -gel effects on eroded human dentin subjected to in situ erosive/ abrasive episodes. Seventy-two previously eroded dentin slabs (0.05 M citric acid, pH 2.3, 20 min) were allocated to 6 groups (n=12) according to the treatment to be performed during the in situ phase and number of erosive/abrasive cycles, as follows: 4% TiF 4 -gel applied once (TiF 4 1), twice (TiF 4 2) or three times (TiF 4 3) followed by 1, 2 and 3 erosive/ abrasive cycles, respectively. Gel was applied before the beginning of the next cycle. Control groups were subjected to 1 (C1), 2 (C2) and 3 (C3) erosive/abrasive cycles only. A seventh group (n=12) comprised in vitro uneroded samples (UN) subjected to 3 erosive/ abrasive cycles. Each cycle corresponded to 2 days of erosive (citric acid 0.5%, pH 2.6, 6x/day) and abrasive (electric toothbrush, 10 s/sample, 1 x/day) challenges. Samples were evaluated under profilometry and environmental scanning electron microscopy (ESEM). Atomic force microscopy images (AFM) were also made (n=3). Repeated measures 2-way ANOVA and Tukey test (p<0.001) showed that TiF 4 2, which did not differ from TiF 4 1 and TiF 4 3, revealed a significant reduction in surface loss compared to all control groups. TiF 4 1 and TiF 4 3 showed no significant difference from C1, but both groups demonstrated significantly smaller surface loss than C2 and C3. ESEM and AFM micrographs suggested alterations on treated surfaces compared to samples from control groups, showing reduced diameters of dentinal tubules lumens. Therefore, TiF 4 was able to reduce the progression of erosive/abrasive lesions.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

The In Situ Effect of Titanium Tetrafluoride Gel on Erosion/Abrasion Progression in Human Dentin

et al. 2017

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“…There is a plethora of models in the literature [Ganss et al, 2001[Ganss et al, , 2010[Ganss et al, , 2014Schlueter et al, 2007;Wiegand et al, 2008Hara et al, 2013;Borges et al, 2014;Basting et al, 2015], with variations in the number of cycles, incubation periods, and days of treatment. Our chosen protocol of 6 daily cycles of de-remineralization for 5 days showed the most significant difference between our negative (no treatment) and positive (AmF/NaF/ SnCl 2 ) controls.…”

Section: Discussionmentioning

confidence: 99%

Effect of Phosphorylated Chitosan on Dentin Erosion: An in vitro Study

Beltrame

Suchyta²,

Alraheam³

et al. 2018

Caries Res

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The aim of this study was to evaluate the antierosive effect of phosphorylated chitosan in dentin. Bovine dentin specimens were randomly distributed into the following groups: (1) no treatment (NoTx/negative control), (2) phosphate-buffered saline solution (PBS), (3) AmF/NaF/SnCl₂ (positive control), (4) 0.5% chitosan solution (Chi), (5) 0.5% neutral phosphorylated (NP)-Chi, and (6) 0.5% alkaline phosphorylated (AP)-Chi. The specimens were submitted to de-remineralization treatment cycles for 5 days: 0.5% citric acid (2 min), remineralizing solution (30 min), and surface treatment according to assigned groups (2 min, 6×/day). The loss of dentin surface was measured by profilometry. Hardness and modulus of elasticity were measured using a nanoindenter equipped with a Berkovich diamond tip. The dentin surface was analyzed by scanning electron microscopy (SEM). The largest loss of dentin was observed in the No Tx and PBS groups (approx. 25 µm). The group treated with AmF/NaF/SnCl₂ showed less loss of dentin (67% reduction vs. NoTx and PBS), followed by the groups treated with NP-Chi and AP-Chi (33% reduction), and Chi (18% reduction). Nanohardness and modulus of elasticity were similar in the NoTx and PBS groups, with a small increase in stiffness in all other groups. SEM revealed that the experimental solution of AP-Chi had a favorable effect on maintaining the integrity of collagen fibrils. AmF/NaF/SnCl₂ showed a preserved mineralized collagen surface. Further studies are warranted to explore this nontoxic phosphorylated chitosan polymer as an effective agent in the prevention and treatment of dental erosion.

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“…Besides, prolonged application times, between 2 and 4 minutes, may favor the retention of F -on the dental surface 35 and decrease mineral loss by dental tissue under acid action 19 . The ideal clinical application frequency has not still been determined, but it is known that TiF 4 is capable of modifying surface morphology since its first application 43 , leading to the formation of a smoother surface 49 and covered by precipitate both in enamel 38 and in dentin 50 . However, re-application of the fluoride may favor the reduction of substrate loss after tissue exposure to erosive solutions 43 and to promote certain obliteration of tubule entrance 49 , which could also lead to reduction of dentin hypersensitivity.…”

Section: Titanium Tetrafluoridementioning

confidence: 99%

Titanium Tetrafluoride (TiF4) in the Treatment of Dental Erosion

Mantilla

Freitas

2018

J. Health Scie.

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Dental erosion is a multifactorial pathology that leads to dental substrate loss caused by its exposure to acids of non-bacterial origin. The process begins with a superficial demineralization of enamel, which, when continuously exposed to erosive solutions, can even lead to dentin exposure, causing aesthetic/functional problems to patients, besides increasing the chances of dentin hypersensitivity. Fluoride ResumoA erosão dental é uma patologia multifatorial que leva a uma perda de substrato dental causada pela sua exposição a ácidos de origem não-bacteriana. O processo se inicia com uma desmineralização superficial do esmalte, que, quando da continua exposição a soluções erosivas, pode levar a exposição do esmalte, causando problemas estéticos/funcionais aos pacientes, além de aumentar a chance de hipersensibilidade dentinária. Os produtos fluoretados, quando aplicados sobre a superfície dental, formam uma barreira física de proteção, que também pode agir como reservatório de íons F. Entretanto, frente a recorrentes desafios erosivos, esta proteção tem efetividade limitada. A literatura recente já demonstrou a capacidade de compostos contendo cátions metálicos polivalentes associados a fluoretos, incluindo o tetrafluoreto de titânio (TiF 4 ), para formar camadas mais ácido-resistentes. A capacidade do íon titânio de se ligar simultaneamente aos íons F e ao tecido dental permite a formação de uma barreira de difusão na superfície dental, conhecida como glaze, que a protege contra desmineralização ácida. Entretanto, ainda é necessário estabelecer um protocolo clínico ideal envolvendo a definição de fatores capazes de determinar o sucesso do tratamento, como concentração, pH, veículo e forma/tempo de aplicação, além da frequência para reaplicação. A presente revisão crítica tem como objetivo proporcionar uma breve visão geral dos mecanismos de ação do TiF 4 e discutir os fatores que podem melhorar sua capacidade protetora contra a erosão dental.Palavras-chave: Erosão Dentária. Flúor. Titânio.

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Nanomechanical properties, SEM, and EDS microanalysis of dentin treated with 2.5% titanium tetrafluoride, before and after an erosive challenge

Cited by 25 publications

References 35 publications

The In Situ Effect of Titanium Tetrafluoride Gel on Erosion/Abrasion Progression in Human Dentin

The In Situ Effect of Titanium Tetrafluoride Gel on Erosion/Abrasion Progression in Human Dentin

Effect of Phosphorylated Chitosan on Dentin Erosion: An in vitro Study

Titanium Tetrafluoride (TiF4) in the Treatment of Dental Erosion

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