Nanomaterials in medicine and pharmaceuticals: nanoscale materials developed with less toxicity and more efficacy

Using hyaluronic acid-functionalized pH stimuli-responsive mesoporous silica nanoparticles for targeted delivery to CD44-overexpressing cancer cells

“…In recent decades, nanomaterials have been widely used in nanomedicine as potential diagnostic and therapeutic agents for cancer imaging and treatment, with less toxicity and improved efficacy. 3,4 Targeted delivery of more efficient cancer treatments has been well documented and is vital to distribute the drug throughout the body to minimize the side effects, which is desirable in order to increase the anticancer drug concentration at the target sites. 5 The major goal of chemotherapy is to ensure the safe and efficient transportation of drug molecules to the targeted sites.…”

“…HeLa cells were seeded in 12-well plates at a density of 2×10 4 per well. The cells, after 8 h washing with PBS, were incubated with 30 μg/mL FITC-labeled DOX@MSNs, DOX@PL-MSNs, DOX@L-MSNs, and DOX solution in 2 mL serum-free DMEM medium.…”

Assembly of Multicomponent Nano-Bioconjugates Composed of Mesoporous Silica Nanoparticles, Proteins, and Gold Nanoparticles

“…1−3 Nanodevices take advantage of the specific physicochemical properties of matter at the nanoscale and thus behave differently from their bulk counterparts. 4 There is a wide range of biomedical nanodevices, and various combinations of them exist. A relevant example is provided by mesoporous silica nanoparticles (MSNs), 5 which are very promising drug delivery systems.…”

Nanoengineered cell membrane-based nanoparticles for tumor and immunocompetent cells modulation

“…Nanotechnology is one of the areas that contribute to increase the specificity of treatments and the development of new materials applicable to human health. 3 Nanomedicine aid diagnosis techniques and disease treatments, like magnetic resonance imaging, hyperthermia, and drug delivery, using concepts from chemistry, physics, and biotechnology. 4 For example, organic and inorganic nanoparticles can be modified to "address" cytotoxic activity in diseased tissues orand organs.…”

“…4 For example, organic and inorganic nanoparticles can be modified to "address" cytotoxic activity in diseased tissues orand organs. 3 For example, the deposition of cellular biomarkers (specific for each cell class) on nanoparticle's surface allows the delivery of drugs or contrast agents to the cells of interest, in order to increase the specificity of treatments and improve diagnostic accuracy, respectively. 3 In the medical and biomedical areas, nanoparticles (NPs) carry antineoplastic agents, such as proteins, nucleic acids, and drugs, delivering high concentrations of the drugs within target cells in order to minimize unwanted toxicity in healthy tissues.…”