“…14,23 However, complex synthesis procedures, poor water solubility, and most importantly high cytotoxicity and inferior biocompatibility constantly block them from efficient practical biological monitoring and imaging applications. 24,25 By contrast, a uorescent sensor made from nanoparticles has excellent biological affinity and unique photoelectric characteristics, [26][27][28][29] especially for those which are built up by choosing carbon as the basic framework of nanometer quantum dots, not only endowing them with diversied structural variability and abundant modiability, but also enjoying the advantages of abundant and affordable precursors, green and convenient synthesis procedures as well as exceptional characteristics, such as excellent water solubility, negligible toxicity, and terric biocompatibility. [30][31][32][33] These advantages make carbon quantum dots particularly suitable for the real-time detection and imaging of biological activity markers in multitudinous biological events, including polarity response.…”