Red emissive carbon dots as a fluorescent sensor for fast specific monitoring and imaging of polarity in living cells

Yang, Zheng; Li, Hui; Xu, Tiantian; She, Mengyao; Chen, Jiao; Liu, Ping; Liu, Xiangrong; Li, Jianli

doi:10.1039/d2ta09462b

Cited by 36 publications

(16 citation statements)

References 69 publications

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“…As a result, the advantages of red emissive QCNSs, including plausible stability, simple synthesis, low toxicity, water solubility, inherent analyte selectivity, wide excitation and emission range, high quantum yield, and versatile surface functionalization, make them highly suitable for sensing applications in diverse fields such as biomedicine, environmental monitoring and chemical analysis. 44,45…”

Section: Analyst Papermentioning

confidence: 99%

Red-emissive carbon nanostructure-anchored molecularly imprinted Er-BTC MOF: a biosensor for visual anthrax monitoring

Dashtian¹,

Norouzi²,

Amourizi³

et al. 2023

Analyst

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Section: Analyst Papermentioning

confidence: 99%

Red-emissive carbon nanostructure-anchored molecularly imprinted Er-BTC MOF: a biosensor for visual anthrax monitoring

Dashtian¹,

Norouzi²,

Amourizi³

et al. 2023

Analyst

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“…The surface chemistry of OR-CDs was deduced by FTIR spectra. The characteristic absorption of functional groups at 3383 and 3217 cm –1 represented υ(O–H) and υ(N–H) . The stretching vibrations of the CO, CN, and C–N were observed at 1615, 1502, and 1313 cm –1 , respectively (Figure b) .…”

Section: Resultsmentioning

confidence: 97%

Rational Design of Orange-Red Emissive Carbon Dots for Tracing Lysosomal Viscosity Dynamics in Living Cells and Zebrafish

et al. 2023

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Lysosomal viscosity is an essential microenvironment parameter in lysosomes, which is closely associated to the occurrence and development of various diseases, including cancer. Thus, accurately quantifying lysosomal viscosity changes is highly desirable for a better understanding of the dynamics and biological functions of lysosomes. In this study, lysosome self-targetable orange-red emissive carbon dots (OR-CDs) were rationally designed and developed for monitoring lysosomal viscosity fluctuations. The enhanced fluorescence of OR-CDs could be obviously observed as the viscosity increased from 1.07 to 950 cP. Moreover, the as-prepared OR-CDs could quickly enter cells for lysosome-targeting imaging and visualize viscosity variations in living cells and zebrafish. More importantly, by utilizing OR-CDs, we successfully achieved tracing the variations in lysosomal viscosity during the autophagy process. Additionally, as cancer cells possess high viscosity than normal cells, the OR-CDs have been effectively utilized for cancer imaging from cell, tissue, and organ to in vivo levels. It is expected that the developed OR-CDs not only provide a meaningful tool for visualizing investigations of lysosome viscosity-related diseases but also shed light on the development based on the nanomaterial for the clinical diagnosis of cancer.

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“…Specifically, under excitation the solvent molecules have the opportunity to rotationally reorient to stabilize the excited-state dipole moment. This phenomenon as depicted is known as solvent relaxation, which is a key feature of both positive and negative solvatochromism [ 67 , 68 , 69 ]. Under this condition, we believe that 813-CDs experience a lowering of the energy of their excited state.…”

Section: Resultsmentioning

confidence: 99%

Investigation into Red Emission and Its Applications: Solvatochromic N-Doped Red Emissive Carbon Dots with Solvent Polarity Sensing and Solid-State Fluorescent Nanocomposite Thin Films

et al. 2023

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In this work, a NIR emitting dye, p-toluenesulfonate (IR-813) was explored as a model precursor to develop red emissive carbon dots (813-CD) with solvatochromic behavior with a red-shift observed with increasing solvent polarity. The 813-CDs produced had emission peaks at 610 and 698 nm, respectively, in water with blue shifts of emission as solvent polarity decreased. Subsequently, 813-CD was synthesized with increasing nitrogen content with polyethyleneimine (PEI) to elucidate the change in band gap energy. With increased nitrogen content, the CDs produced emissions as far as 776 nm. Additionally, a CD nanocomposite polyvinylpyrrolidone (PVP) film was synthesized to assess the phenomenon of solid-state fluorescence. Furthermore, the CDs were found to have electrochemical properties to be used as an additive doping agent for PVP film coatings.

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Red emissive carbon dots as a fluorescent sensor for fast specific monitoring and imaging of polarity in living cells

Abstract: Polarity is an integral microenvironment parameter which is crucial for establishing and reflecting a large number of sophisticated physiological functions and pathological effects. Monitoring the changes of intracellular polarity is...

Cited by 36 publications

References 69 publications

Red-emissive carbon nanostructure-anchored molecularly imprinted Er-BTC MOF: a biosensor for visual anthrax monitoring

Red-emissive carbon nanostructure-anchored molecularly imprinted Er-BTC MOF: a biosensor for visual anthrax monitoring

Rational Design of Orange-Red Emissive Carbon Dots for Tracing Lysosomal Viscosity Dynamics in Living Cells and Zebrafish

Investigation into Red Emission and Its Applications: Solvatochromic N-Doped Red Emissive Carbon Dots with Solvent Polarity Sensing and Solid-State Fluorescent Nanocomposite Thin Films

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