Nanofibrous silk fibroin/reduced graphene oxide scaffolds for tissue engineering and cell culture applications

Nalvuran, Hande; Elçin, Ayşe Eser; Elçin, Yaşar Murat

doi:10.1016/j.ijbiomac.2018.03.072

Cited by 60 publications

(40 citation statements)

References 45 publications

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“…The nanofibers produced by electrospinning have excellent characteristics such as small diameter and uniform size distribution. Electrospun SF nanofibers have attracted much attention in the field of tissue engineering [ 17 , 18 ]. Nalvuran et al [ 17 ] used electrospinning to obtain nanofibrous SF/reduced graphene oxide scaffolds for tissue engineering and cell culture applications.…”

Section: Introductionmentioning

confidence: 99%

High-Throughput Preparation of Silk Fibroin Nanofibers by Modified Bubble-Electrospinning

Fang

Wang

2018

Nanomaterials

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As a kind of natural macromolecular protein molecule extracted from silk, silk fibroin (SF) has been widely used as biological materials in recent years due to its good physical and chemical properties. In this paper, a modified bubble-electrospinning (MBE) using a cone-shaped gas nozzle combined with a copper solution reservoir was applied to obtain high-throughput fabrication of SF nanofibers. In the MBE process, sodium dodecyl benzene sulfonates (SDBS) were used as the surfactant to improve the spinnability of SF solution. The rheological properties and conductivity of the electrospun SF solutions were investigated. And the effects of gas flow volume, SF solution concentration and additive amounts of SDBS on the morphology, property and production of SF nanofibers were studied. The results showed the decrease of gas flow volume could decrease the nanofiber diameter, enhance the diameter distribution, and increase the production of nanofibers. And the maximum yield could reach 3.10 g/h at the SF concentration of 10 wt % and the SDBS concentration of 0.1 wt %.

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Section: Introductionmentioning

confidence: 99%

High-Throughput Preparation of Silk Fibroin Nanofibers by Modified Bubble-Electrospinning

Fang

Wang

2018

Nanomaterials

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“…The comparable TGA curves were observed in SF fiber and SF/GT nanocomposites after the addition of GT. Rapid weightlessness was observed in the matrix nanofibers in a similar temperatures range and the low grade of the GT loading in nanofibers does not result in a clear decomposition step corresponding to GT . However, slight differences can be detected when comparing the curves of SF and SF/GT composite nanofibers.…”

Section: Resultsmentioning

confidence: 99%

High antibacterial performance of electrospinning silk fibroin/gelatin film modified with graphene oxide‐sliver nanoparticles

Zhang

Cai

et al. 2019

J of Applied Polymer Sci

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In this study, graphene oxide-sliver nanoparticle (GO-AgNP) composite was synthesized in situ with GO as the raw material. Fourier transform infrared spectroscopy (FTIR), transmission electron microscopy, and scanning electron microscopy were used to characterize the composite, the spherical Ag particles with a diameter of about 36 nm were well deposited on the surface of GO nanosheets without serious agglomeration, and the antibacterial properties of the composites were also tested. Moreover, the silk fibroin (SF)/gelatin (GT) electrospun nanofiber film was prepared by electrospinning, and the structure of the SF nanofiber film was observed using a Fourier transform infrared spectrometer, X-ray diffractometer, and scanning electron microscope. The TGA curves indicated that the total weight loss rate of SF nanofibers at 400 C was significantly higher than that of SF/GT composite nanofibers (74.72% for pure SF, 62.37% for SF/GT nanocomposites). Finally, the GO-AgNP composite was combined with electrospinning SF film, which resulted in the decrease in surface roughness from 393.5 AE 123.7 nm to 109.9 AE 24.43 nm and the decrease in contact angle from 82.48 to 54.78 . Besides, the GO-AgNP composites enhanced the antibacterial performance of SF film greatly, which was conducive to its application in biological tissue engineering.

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“…However, the change of SF structure was different from that already mentioned, when composite materials of graphene‐family materials and SF were fabricated by freeze‐drying, the SA‐LbL method, electrospinning, and other methods. With increasing concentration of graphene‐family materials, the content of silk II structure (β‐sheet) in composites increased, without any evidence of a downward trend ,. The mechanical properties of the composite materials were also increased significantly at higher concentrations of graphene‐family materials within the specified range ,.…”

Section: Combined Application Of Graphene‐family Materials and Sfmentioning

confidence: 97%

Combined Application of Graphene‐Family Materials and Silk Fibroin in Biomedicine

et al. 2019

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The main graphene‐family materials used in biomedicine include graphene, graphene oxide, and reduced graphene oxide. They have been well documented for their distinctive microstructure and excellent physicochemical properties. Although they also have some shortcomings, such as slow biodegradation and dose‐dependent biotoxicity, these problems can be solved by using them in conjunction with other biomaterials. Silk fibroin (SF), a natural polymer material with many advantageous properties, has been used widely in biomedicine. However, SF requires modification by other biomaterials to improve its mechanical properties and control its degradation rate for further use. In recent years, the combined application of graphene‐family materials and SF has increased gradually, and the effects of it on cell behavior have been preliminary investigated, such as promoting cell adhesion, proliferation, and differentiation. Further studies of the combined use have been conducted in biomedicine, including tissue engineering, biosensor, and other biomedical usage. In this paper, this combined application has been outlined and summarized, and some envisioned challenges and future perspectives have been mentioned. We hope that this review will provide some reference and inspiration for the combined application of graphene‐family materials and SF in biomedicine in the future.

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Nanofibrous silk fibroin/reduced graphene oxide scaffolds for tissue engineering and cell culture applications

Cited by 60 publications

References 45 publications

High-Throughput Preparation of Silk Fibroin Nanofibers by Modified Bubble-Electrospinning

High-Throughput Preparation of Silk Fibroin Nanofibers by Modified Bubble-Electrospinning

High antibacterial performance of electrospinning silk fibroin/gelatin film modified with graphene oxide‐sliver nanoparticles

Combined Application of Graphene‐Family Materials and Silk Fibroin in Biomedicine

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