Nanofibrous and nanoparticle materials as drug-delivery systems

Zamani, Fatemeh; Jahanmard, Fatemeh; Ghasemkhah, Farzaneh; Amjad‐Iranagh, Sepideh; Bagherzadeh, Roohollah; Tehran, Mohammad Amani; Latifi, Masoud

doi:10.1016/b978-0-323-46143-6.00007-5

Cited by 24 publications

(19 citation statements)

References 190 publications

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“…Electrospun nanofibers are regarded as a promising ECM‐mimicking platform and the effective delivery system of biomolecules which can provide physical support for cellular growth to modulate tissue regeneration . Incorporating biomolecules into scaffold interiors can be obtained by directly mixing the biomolecules in a polymer solution during the electrospinning process (as named blend electrospinning) and provides bioactive scaffolds with an initial burst release followed by a sustained release .…”

Section: Introductionmentioning

confidence: 99%

“…[4][5][6] Electrospun nanofibers are regarded as a promising ECMmimicking platform and the effective delivery system of biomolecules which can provide physical support for cellular growth to modulate tissue regeneration. [7][8][9][10][11] Incorporating biomolecules into scaffold interiors can be obtained by directly mixing the biomolecules in a polymer solution during the electrospinning process (as named blend electrospinning) and provides bioactive scaffolds with an initial burst release followed by a sustained release. 12,13 However, these electrospun scaffolds possess some drawbacks for applying in tissue engineering including losing the bioactivity and reducing the therapeutic efficiency of biomolecules due to conformational changes in organic environments or shortening the lifetime of bioactive scaffolds due to their initial burst release.…”

Section: Introductionmentioning

confidence: 99%

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Potential core–shell designed scaffolds with a gelatin‐based shell in achieving controllable release rates of proteins for tissue engineering approaches

Ghasemkhah

Latifi

Hadjizadeh

et al. 2019

J Biomedical Materials Res

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The biomaterials design as core–shell structures opens a new door to the release of susceptible biomolecules in a controllable manner and enables to place natural biomaterials as shell layers to impart the effective biofunctional features at surfaces. In this study, core–shell designed scaffolds were prepared using coaxial electrospinning with hybrid of gelatin (GT)/polycaprolactone (PCL) at different weight ratios as their shell and protein solution as their core, followed by cross‐linking to impart controllable release rates, tunable mechanical properties, and enhanced cytocompatibility. SEM, FM, and TEM confirmed the successful production of uniform core–shell nanofibers and homogeneous protein distribution. Results showed that an increase in GT proportion in the shell resulted in a decrease in fiber diameter, an increase of Young's modulus, and an intense burst release of BSA 0.2% which could be controlled through cross‐linking. The mechanical tests revealed that the GT/PCL combining and cross‐linking improved mechanical properties which correlated with an increase in spreading and proliferation of HUVECs. A slight burst release was also detected from BSA 0.05% and EGF encapsulated GT73P‐cross‐linked scaffold which demonstrated their applicability for a controlled release of dilute proteins. We were able to successfully incorporate two types of protein with different concentrations without supporting polymer into the GT shell to provide scaffolds possessing tunable mechanical properties and controllable release rates through blending with PCL at different ratios and/or cross‐linking. These findings are promising to promote delivery systems of angiogenic growth factors that are needed a sustained release with different rates at each angiogenesis stage. © 2019 Wiley Periodicals, Inc. J Biomed Mater Res Part A, 2019.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Potential core–shell designed scaffolds with a gelatin‐based shell in achieving controllable release rates of proteins for tissue engineering approaches

Ghasemkhah

Latifi

Hadjizadeh

et al. 2019

J Biomedical Materials Res

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“…In the process of coaxial electrospinning, changing the shell layer flow rate, the shell solution concentration, and the core layer flow rate can produce shell layers of different thicknesses and thus control the release rate [ 14 , 18 ]. Coaxial nanofibers can also be combined with nanoparticle materials to slow down the burst release behavior of drugs [ 19 ]. Generally speaking, nanofibers with core-shell structures are promising platforms for drug delivery.…”

Section: Introductionmentioning

confidence: 99%

“…The ideal drug carriers should be compatible, and drug release behavior based on biodegradable materials is favorable in controlling sustained drug release [ 1 , 19 ]. PCL and PLA are both biocompatible, biodegradable, and non-toxic synthetic polymer materials.…”

Section: Introductionmentioning

confidence: 99%

Antibacterial Porous Coaxial Drug-Carrying Nanofibers for Sustained Drug-Releasing Applications

Chen

et al. 2021

Nanomaterials

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The phenomenon of drug burst release is the main problem in the field of drug delivery systems, as it means that a good therapeutic effect cannot be acheived. Nanofibers developed by electrospinning technology have large specific surface areas, high porosity, and easily controlled morphology. They are being considered as potential carriers for sustained drug release. In this paper, we obtained polycaprolactone (PCL)/polylactic acid (PLA) core-shell porous drug-carrying nanofibers by using coaxial electrospinning technology and the nonsolvent-induced phase separation method. Roxithromycin (ROX), a kind of antibacterial agent, was encapsulated in the core layer. The morphology, composition, and thermal properties of the resultant nanofibers were characterized by scanning electron microscopy (SEM), attenuated total reflection Fourier transform infrared (ATR-FTIR) spectroscopy, differential scanning calorimetry (DSC) and thermogravimetry analysis (TGA). Besides this, the in vitro drug release profile was investigated; it showed that the release rate of the prepared coaxial porous nanofibers with two different pore sizes was 30.10 ± 3.51% and 35.04 ± 1.98% in the first 30 min, and became 92.66 ± 3.13% and 88.94 ± 1.58% after 14 days. Compared with the coaxial nonporous nanofibers and nanofibers prepared by uniaxial electrospinning with or without pores, the prepared coaxial porous nanofibers revealed that the burst release was mitigated and the dissolution rate of the hydrophobic drugs was increased. The further antimicrobial activity demonstrated that the inhibition zone diameter of the coaxial nanofibers with two different pore sizes was 1.70 ± 0.10 cm and 1.73 ± 0.23 cm, exhibiting a good antibacterial effect against Staphylococcus aureus. Therefore, the prepared nanofibers with the coaxial porous structures could serve as promising drug delivery systems.

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“…This method is used to eliminate or inhibit gingival bacteria flora, decrease inflammation, and help to discontinue bone desorption. However, conventional drug administration pathways also have many drawbacks such as serious side effects, poor biodistribution, low selectivity of the therapeutic effect, burst release of the drug, and damage to healthy cells [ 6 , 7 ]. The efficacy of conventional antimicrobial therapy has often been hampered by the difficulties of achieving and maintaining an appropriate concentration of curative agents at the periodontal site when a low dose of the drug is given.…”

Section: Introductionmentioning

confidence: 99%

Polymeric Carriers for Delivery Systems in the Treatment of Chronic Periodontal Disease

et al. 2020

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Periodontitis (PD) is a chronic inflammatory disease of periodontal tissues caused by pathogenic microorganisms and characterized by disruption of the tooth-supporting structures. Conventional drug administration pathways in periodontal disease treatment have many drawbacks such as poor biodistribution, low selectivity of the therapeutic effect, burst release of the drug, and damage to healthy cells. To overcome this limitation, controlled drug delivery systems have been developed as a potential method to address oral infectious disease ailments. The use of drug delivery devices proves to be an excellent auxiliary method in improving the quality and effectiveness in periodontitis treatment, which includes inaccessible periodontal pockets. This review explores the current state of knowledge regarding the applications of various polymer-based delivery systems such as hydrogels, liposomes, micro-, and nanoparticles in the treatment of chronic periodontal disease. Furthermore, to present a more comprehensive understanding of the difficulties concerning the treatment of PD, a brief description of the mechanism and development of the disease is outlined.

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Nanofibrous and nanoparticle materials as drug-delivery systems

Cited by 24 publications

References 190 publications

Potential core–shell designed scaffolds with a gelatin‐based shell in achieving controllable release rates of proteins for tissue engineering approaches

Potential core–shell designed scaffolds with a gelatin‐based shell in achieving controllable release rates of proteins for tissue engineering approaches

Antibacterial Porous Coaxial Drug-Carrying Nanofibers for Sustained Drug-Releasing Applications

Polymeric Carriers for Delivery Systems in the Treatment of Chronic Periodontal Disease

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