Nanoencapsulation of Docetaxel Induces Concurrent Apoptosis and Necroptosis in Human Oral Cancer Cells (SCC-9) via TNF-α/RIP1/RIP3 Pathway

Gupta, Parul; Singh, Arpita; Verma, Ajay Kumar; Kant, Surya; Pandey, Anuj Kumar; Mishra, Anupam; Khare, Puneet; Prakash, Ved

doi:10.1007/s12291-022-01055-7

Cited by 3 publications

(3 citation statements)

References 40 publications

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“…Moreover, the development of targeted delivery systems such as PLGA-Dtx (poly-lactic-co-glycolic acid nanoparticles containing docetaxel) has shown enhanced efficacy in inhibiting cancer cell proliferation. This strategy induced both apoptosis and necroptosis in oral cancer cells [89]. These results altogether suggest a potential role for these compounds in triggering necroptosis in OSCC cells.…”

Section: Necroptosismentioning

confidence: 61%

“…Among the selected studies, 46 studies evaluated ferroptosis , 22 studies focused on pyroptosis [28,33,[64][65][66][67][68][69][70][71][72][73][74][75][76][77][78][79][80][81][82][83], 8 studies on necroptosis [84][85][86][87][88][89][90][91] and 5 studies on other types of cell death [92][93][94][95][96]. One study [28] explored both ferroptosis and pyroptosis, Among the selected studies, 46 studies evaluated ferroptosis , 22 studies focused on pyroptosis [28,33,[64][65][66][67][68][69][70][71][72][73]…”

Section: Resultsmentioning

confidence: 99%

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Exploring beyond Common Cell Death Pathways in Oral Cancer: A Systematic Review

Siquara da Rocha,

de Morais,

de Oliveira

et al. 2024

Biology

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Oral squamous cell carcinoma (OSCC) is the most common and lethal type of head and neck cancer in the world. Variable response and acquisition of resistance to traditional therapies show that it is essential to develop novel strategies that can provide better outcomes for the patient. Understanding of cellular and molecular mechanisms of cell death control has increased rapidly in recent years. Activation of cell death pathways, such as the emerging forms of non-apoptotic programmed cell death, including ferroptosis, pyroptosis, necroptosis, NETosis, parthanatos, mitoptosis and paraptosis, may represent clinically relevant novel therapeutic opportunities. This systematic review summarizes the recently described forms of cell death in OSCC, highlighting their potential for informing diagnosis, prognosis and treatment. Original studies that explored any of the selected cell deaths in OSCC were included. Electronic search, study selection, data collection and risk of bias assessment tools were realized. The literature search was carried out in four databases, and the extracted data from 79 articles were categorized and grouped by type of cell death. Ferroptosis, pyroptosis, and necroptosis represented the main forms of cell death in the selected studies, with links to cancer immunity and inflammatory responses, progression and prognosis of OSCC. Harnessing the potential of these pathways may be useful in patient-specific prognosis and individualized therapy. We provide perspectives on how these different cell death types can be integrated to develop decision tools for diagnosis, prognosis, and treatment of OSCC.

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Section: Necroptosismentioning

confidence: 61%

Section: Resultsmentioning

confidence: 99%

Exploring beyond Common Cell Death Pathways in Oral Cancer: A Systematic Review

Siquara da Rocha,

de Morais,

de Oliveira

et al. 2024

Biology

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“…Currently, the mortality and morbidity of OSCC patients remain high, which is still a growing global health concern [ 1 , 2 , 32 ]. The roles of necroptosis in various types of tumors have been reported, but there is limited information regarding the treatment of OSCC through the necroptotic mechanism [ 2 ].…”

Section: Discussionmentioning

confidence: 99%

Prognostic Value of Necroptosis-Related Genes Signature in Oral Squamous Cell Carcinoma

Huang,

Gu,

et al. 2023

Cancers

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The dual role of necroptosis in inhibiting and promoting tumor development has gradually received much attention because of its essential significance for targeted treatment. Accordingly, this study aims to explore the relationship between necroptosis and oral squamous cell carcinoma (OSCC), and search for novel prognostic factors for OSCC. RNA-seq data and clinical information were downloaded from TCGA and GTEx databases. The prognostic signature of necroptosis-related genes (NRGs) was constructed by univariate Cox regression analysis and the LASSO Cox regression model. Moreover, survival analyses, ROC curves, and nomograms were adopted to further analyze. GO and KEGG analyses and immune infiltration analyses were used for function enrichment and immune feature research in turn. The NRG prognostic signature expression was higher in OSCC tissues than in normal tissues, and the overall survival (OS) rate of the high-expression group was much lower. HPRT1 was proved to be an independent prognostic factor in OSCC. Furthermore, the function enrichment analyses revealed that NRGs were involved in necroptosis, apoptosis, inflammation, and immune reaction. The expression of NRGs was related to immunosuppression in OSCC. Furthermore, the knockdown of HPRT1 could suppress the proliferation and migration of OSCC. In conclusion, the high expression of NRG prognostic signature is associated with poor prognosis in OSCC, and HPRT1 can serve as a novel independent prognostic factor for OSCC.

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