Nanocrystalline hydroxyapatite ceramics produced by low-temperature sintering after high-pressure treatment

Фомин, А. С.; Баринов, С. М.; Иевлев, В. М.; Смірнов, В. В.; Михайлов, Б. П.; Belonogov, E. K.; Дроздова, Н. А.

doi:10.1134/s0012500808010084

Cited by 41 publications

(25 citation statements)

References 6 publications

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“…Such nanostructured systems constitute a bridge between single molecules and bulk material systems [165]. For instance, powders of nanocrystalline apatites [166][167][168][169][170][171][172] and β-TCP [173] were found to exhibit an improved sinterability and enhanced densification due to a greater surface area. This is explained by the fact that the distances of material transport during the sintering becomes shorter for ultrafine powders with a high specific surface area, resulting in a densification at a low temperature.…”

Section: Micron-and Submicron-sized Calcium Orthophosphates Versus Thmentioning

confidence: 99%

“…Other preparation techniques of nano-sized apatite might be found elsewhere [275]. Bulk bioceramics made of nanocrystalline HA with a grain size of no more than 50 nm and a near-theoretical density might be prepared by application of a high (~ 3.5 GPa) pressure in uniaxial compaction of nanodimensional powders with subsequent sintering at 640 °C [168]. A similar approach was reported by another research group [406].…”

Section: Yearmentioning

confidence: 99%

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Nanodimensional and Nanocrystalline Calcium Orthophosphates

Dorozhkin¹

2012

AJBE

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Nano-sized particles and crystals play an important role in the formation of calcified tissues of various animals. For example, nano-sized and nanocrystalline calcium orthophosphates in the form of apatites of biological origin represent the basic inorganic building blocks of bones and teeth of mammals. Namely, according the recent developments in biomineralization, tens to hundreds nanodimensional crystals of a biological apatite are self-assembled into these complex structures. This process occurs under a strict control by bioorganic matrixes. Furthermore, both a greater viability and a better proliferation of various types of cells have been detected on smaller crystals of calcium orthophosphates. Thus, the nano-sized and nanocrystalline forms of calcium orthophosphates have a great potential to revolutionize the hard tissue-engineering field, starting from bone repair and augmentation to controlled drug delivery systems. This review reports on current state of the art and recent developments on the subject, starting from synthesis and characterization to biomedical and clinical applications. Furthermore, the review also discusses possible directions for future research and development.

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Section: Micron-and Submicron-sized Calcium Orthophosphates Versus Thmentioning

confidence: 99%

Section: Yearmentioning

confidence: 99%

Nanodimensional and Nanocrystalline Calcium Orthophosphates

Dorozhkin¹

2012

AJBE

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“…Calcium phosphate has been the subject of many studies in the last decade because of it biocompatibility, ability to fill bone cavities and properties which are desirable for surgical applications. The synthesis of nanocrystalline calcium hydroxyapatites for the fabrication of composite materials as bone graft substitutes is a critical issue in bioceramic research [1][2][3][4][5][6][7][8][9][10][11].…”

Section: Introductionmentioning

confidence: 99%

Doped calcium carbonate-phosphate used for bone tissue technology

Koroleva¹,

Dobrinskaya²,

Каманцев³

2017

Intergr Clin Med

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Doped with K + , Mg 2+ , Fe 2+ , Zn 2+ , Mn 2+ , Li + , Au 3+ , SiO 2 nanocrystalline calcium carbonate-phosphate extends significantly the functionality for drug delivery: it can be used to speed up the processes of bone repair and bone tissue strengthening. The advantage over other calcium phosphate biomaterials is strengthening of bone and tooth tissues of a human being of any age, the substances being transported through skin to restore broken bones in a critically short period of time regardless of age. The mechanical fracture strength of bone tissue increases almost in 5 times. These studies suggest doped calcium carbonate-phosphate is the most appropriate material, because reduce of the cholesterol rate in the blood in 2-2.5 time. The best results have been observed with concentrations of 5-10% doped calcium carbonatephosphate in the implant used the polycaprolactone. Young`s modulus is maximal for specimens with 5% doped calcium carbonate-phosphate.

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“…Since calcium orthophosphates are either thermally unstable (MCPM, MCPA, DCPA, DCPD, OCP, ACP, CDHA) or have a melting point at temperatures exceeding ~ 1400 °C with a partial decomposition (α-TCP, β-TCP, HA, FA, TTCP), only the first and the second consolidation approaches are used to prepare bulk bioceramics and scaffolds. The methods include uniaxial compaction [198,199], isostatic pressing (cold or hot) [200][201][202][203][204][205][206], granulation [207,208], loose packing [209], slip casting [210][211][212][213], gel casting [188,189,[214][215][216][217][218][219], pressure mold forming [220], injection molding [221], polymer replication [222][223][224][225], extrusion [226][227][228], slurry dipping and spraying [229], as well as to form ceramic sheets from slurries tape casting [124,216,230,231] doctor blade [232] and colander methods might be employed [194][195][196][197]…”

Section: Forming and Shapingmentioning

confidence: 99%

Medical Application of Calcium Orthophosphate Bioceramics

Dorozhkin¹

2011

BIO

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In the late 1960's, a strong interest was raised in biomedical applications of ceramic materials (named bioceramics a little bit later). Bioceramics was initially used as reasonable alternatives to metals in order to increase their biocompatibility. However, within a short period, it has grown into a diverse class of biomaterials, presently including three essential types: relatively bioinert, bioactive (or surface reactive) and bioresorbable bioceramics. This review is limited to bioceramics prepared from calcium orthophosphates only, which belong to the categories of bioactive and bioresorbable compounds. There have been a number of important advances in this field during the past 30 -40 years. The research was shifted from an initial study on the develop-ment of bioinert bioceramics towards bioactive and bioresorbable bioceramics, and these different types of calcium orthophosphate bioceramics can be tuned through the structural and compositional control. At the turn of the millennium, a new concept of calcium orthophosphate bioceramics has been developed to promote a regeneration of bones. Current biomedical applications of calcium orthophosphate bioceramics include artificial replacements for hips, knees, teeth, tendons and ligaments, as well as repair for periodontal disease, maxillofacial reconstruction, augmenttation and stabilization of the jawbone, spinal fusion and bone fillers after tumor surgery. Potential future applications of calcium orthophosphate bioceramics are demonstrated in drug delivery systems, effective carriers of growth factors, bioactive peptides and/or various types of cells for tissue engineering purposes.

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Nanocrystalline hydroxyapatite ceramics produced by low-temperature sintering after high-pressure treatment

Cited by 41 publications

References 6 publications

Nanodimensional and Nanocrystalline Calcium Orthophosphates

Nanodimensional and Nanocrystalline Calcium Orthophosphates

Doped calcium carbonate-phosphate used for bone tissue technology

Medical Application of Calcium Orthophosphate Bioceramics

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