Doped with K + , Mg 2+ , Fe 2+ , Zn 2+ , Mn 2+ , Li + , Au 3+ , SiO 2 nanocrystalline calcium carbonate-phosphate extends significantly the functionality for drug delivery: it can be used to speed up the processes of bone repair and bone tissue strengthening. The advantage over other calcium phosphate biomaterials is strengthening of bone and tooth tissues of a human being of any age, the substances being transported through skin to restore broken bones in a critically short period of time regardless of age. The mechanical fracture strength of bone tissue increases almost in 5 times. These studies suggest doped calcium carbonate-phosphate is the most appropriate material, because reduce of the cholesterol rate in the blood in 2-2.5 time. The best results have been observed with concentrations of 5-10% doped calcium carbonatephosphate in the implant used the polycaprolactone. Young`s modulus is maximal for specimens with 5% doped calcium carbonate-phosphate.
The possibility of obtaining an alloplastic biomaterial for the implant based on doped calcium carbonate-phosphates and polycaprolactone is studied. Nanocrystalline calcium carbonate-phosphate doped with cations of iron, magnesium, potassium, zinc, manganese, and silicon intended for bone repair by drug delivery is investigated. Histological studies have revealed that samples after 60 days in a living organism are covered by a connective tissue capsule. The formation of blood vessels and nerve endings is observed in the capsule.
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