Nanocrystal Suspension of Cefixime Trihydrate Preparation by High-Pressure Homogenization Formulation Design Using 23 Factorial Design

Bhaskar, Rajveer; Patil, Prakash H.

doi:10.22159/ijpps.2017v9i9.19319

Cited by 6 publications

(4 citation statements)

References 34 publications

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“…The Zeta potential of a particle is the overall charge that the particles obtain in a particular medium. Zeta potential values help to assess the stability of the formulation [18,19].…”

Section: Characterization Of Polymeric Nanoparticle Loaded With Nebiv...mentioning

confidence: 99%

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Computational Tools Assisted Formulation Optimization of Nebivolol Hydrochloride Loaded Plga Nanoparticles by 32 Factorial Designs

et al. 2022

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Objective: The aim of the present study was to formulate and optimize the PLGA polymeric nanoparticle of Nebivolol Hydrochloride for sustain release of drug Methods: The drug-excipients interaction was explored by molecular docking studies by in silico tools. The drug-loaded polymeric nanoparticles prepared by emulsion solvent evaporation method using 32 factorial design and characterized for particle size, zeta potential, and entrapment efficiency. Shape and surface morphology was analysed by SEM and TEM. In vitro drug release study was performed by using a diffusion membrane. Results: The docking analysis inferred that the drug has interacted well with PLGA and PF-68, which could prevent the drug crystal formation. The optimized polymeric nanoparticles had a particle size of 291 nm and entrapment efficiency of 83.4% and were found to be within 95% of CI of the predicted value, which is acceptable. SEM and TEM studies showed that the formed polymeric nanoparticles were smooth, spherical in shape and uniform in size. In vitro drug release study of optimized formulation showed sustained release for prolonged time period Conclusion: Based on the computational studies and in vitro release studies, the developed Nebivolol hydrochloride loaded in PLGA nanoparticles could be a promising formulation in oral drug delivery for the treatment of hypertension.

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“…The Zeta potential of a particle is the overall charge that the particles obtain in a particular medium. Zeta potential values help to assess the stability of the formulation [18,19].…”

Section: Characterization Of Polymeric Nanoparticle Loaded With Nebiv...mentioning

confidence: 99%

“…The concentration of Nebivolol Hydrochloride present in the supernatant was analysed by UV spectroscopic method at 281 nm. The percentage entrapment efficiency was calculated using the following formula [19].…”

Section: Percentage Entrapment Efficiencymentioning

confidence: 99%

Computational Tools Assisted Formulation Optimization of Nebivolol Hydrochloride Loaded Plga Nanoparticles by 32 Factorial Designs

et al. 2022

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“…Table 2 shows the selected three variables: spray rate (g/min), atomizing pressure (Bar), and inlet temperature (°C) during process and expected quality attributes, LOD (%), bulk density (g/ml), product temperature (°C), and dissolution (f2). Experimental design with three center points, which were also utilized to evaluate any curvature effect, was designed in Table 3 [8,9]. Eleven batch formulations (300 g each) were prepared by fluid-bed granulator for design of experiments (DoEs) assessment using design expert software version 9.0.5.1 (Stat-Ease Inc., Minneapolis, MN, USA).…”

Section: Preparation Of the Pravastatin Tablet For Reduced Weight Andmentioning

confidence: 99%

A Study of Fluid Bed Granulation of Pravastatin Tablet Using Design of Experiments

Kim

Pyo

2018

Asian J Pharm Clin Res

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Objective: The objective of this study was to reduce size and weight of pravastatin tablet through quality by design approach; potential factors (spray rate, atomizing pressure, and inlet temperature) which could influence on the production process for critical process parameters of wet granulation using fluid-bed granulator were examined.Methods: The manufacturing process of the reduced weight and size formulation pravastatin tablet involves wet granulation, drying, granulate screening, blending, and tableting. Design of experiments study for wet granulation of the reduced weight/size pravastatin tablet was produced on 11 combinations of three factors (spray rate, atomizing pressure, and inlet temperature), which were chosen through initial risk assessment. The process of wet granulation was rated by measuring four responses: loss on drying (LOD) (%), bulk density (g/ml), product temperature (°C), and dissolution similarity (f2).Results: It was measured that LOD varied from 1.46 to 3.24%, bulk density from 0.34 to 0.51 g/ml, product temperature from 40.12 to 51.69°C, and dissolution (f2) of pravastatin from 52.14 to 58.91. Control strategy for wet granulation production of the reduced weight and size pravastatin tablet by our results demonstrated that the most optimized condition of three factors for wet granulation is spray rate (3–5 g/min), atomizing pressure (about 1 bar), and inlet temperature (65–90°C), respectively. Updated risk assessment and justification by all experimental data safely existed within the range of acceptance criteria were presented.Conclusion: It can be concluded that the ideal ranges of three factors (spray rate, atomizing pressure, and inlet temperature) in wet granulation were successfully identified.

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“…[21][22][23] The former primarily employs methods including wet grinding and highpressure homogenization. For example, Rossetti et al 24 prepared atorvastatin calcium nanocrystal suspension by wet grinding, and Bhaskar et al 25 obtained cefixime trihydrate nanocrystal suspension though high-pressure homogenization technology. Both preparation methods have been applied to industrial manufacturing.…”

Section: Introductionmentioning

confidence: 99%

Enhanced Dissolution and Bioavailability of Curcumin Nanocrystals Prepared by Hot Melt Extrusion Technology

Zhao,

Xu,

Dai

et al. 2024

IJN

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Nanocrystal Suspension of Cefixime Trihydrate Preparation by High-Pressure Homogenization Formulation Design Using 23 Factorial Design

Cited by 6 publications

References 34 publications

Computational Tools Assisted Formulation Optimization of Nebivolol Hydrochloride Loaded Plga Nanoparticles by 32 Factorial Designs

Computational Tools Assisted Formulation Optimization of Nebivolol Hydrochloride Loaded Plga Nanoparticles by 32 Factorial Designs

A Study of Fluid Bed Granulation of Pravastatin Tablet Using Design of Experiments

Enhanced Dissolution and Bioavailability of Curcumin Nanocrystals Prepared by Hot Melt Extrusion Technology

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