2022
DOI: 10.22159/ijap.2022v14i4.44865
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Abstract: Objective: The aim of the present study was to formulate and optimize the PLGA polymeric nanoparticle of Nebivolol Hydrochloride for sustain release of drug Methods: The drug-excipients interaction was explored by molecular docking studies by in silico tools. The drug-loaded polymeric nanoparticles prepared by emulsion solvent evaporation method using 32 factorial design and characterized for particle size, zeta potential, and entrapment efficiency. Shape and surface morphology was analysed by SEM and TEM. In … Show more

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Cited by 3 publications
(2 citation statements)
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“…Design-Expert software (Version 13.0.12.0 Trail, Stat Ease Inc, USA) was employed for the generation and evaluation of the 20 experimental runs given in table 1. For optimization of favipiravir nanoparticles, critical formulation attributes were identified to be the polymer (PLGA) fraction, the concentration of stabiliser (PVA), stirring rate, and desired critical quality attributes like particle size (R1), drug entrapment efficiency (R2), and cumulative percentage drug release at 720 min (R3) were selected [16,17].…”
Section: Experimental Designmentioning
confidence: 99%
“…Design-Expert software (Version 13.0.12.0 Trail, Stat Ease Inc, USA) was employed for the generation and evaluation of the 20 experimental runs given in table 1. For optimization of favipiravir nanoparticles, critical formulation attributes were identified to be the polymer (PLGA) fraction, the concentration of stabiliser (PVA), stirring rate, and desired critical quality attributes like particle size (R1), drug entrapment efficiency (R2), and cumulative percentage drug release at 720 min (R3) were selected [16,17].…”
Section: Experimental Designmentioning
confidence: 99%
“…Transdermal delivery of drugs requires penetration through the skin which acts as a barrier to reach the systemic circulation [10]. Various formulation strategies has been applied in order to reach the target site [11,12] and optimisation of formulation parameter was done by using computer tools [13,14]. To improve transdermal delivery, one of the strategies includes use of a microemulsion system which is suitable for hydrophilic and lipophilic drugs.…”
Section: Introductionmentioning
confidence: 99%