Nanocomposites of 2-arylpropionic acid drugs based on Mg–Al layered double hydroxide for dissolution enhancement

New hybrid materials based on layered double hydroxides and antioxidant compounds. Preparation, characterization and release kinetic studies

“…The result indicates that the VA molecules have been stacked as a monolayer oriented perpendicular to the LDH plane, with the carboxylate ions pointing alternatively to the neighboring hydroxide groups in a similar manner described for other intercalated drugs such as fulbriprofen, bezafibrate, clofibric acid, enalpril, amoxicillin and reported in earlier studies [43][44][45].…”

Versatile Nanocomposite Formulation System of Non-Steroidal Anti-Inflammatory Drugs of the Arylalkanoic Acids

“…Successfully, all the studied synthetic techniques showed drug-LDH composites; however the amounts of the incorporated drugs were different. The coprecipitation technique showed the highest loading ratio, while reconstruction method showed the lowest one as noted in Table 1 (Berber et al, 2008) With no doubt, the preparation technique of LDH-composites affected the incorporation process of the drugs into LDH. In the coprecipitation process, the reaction medium contained the metals and the drug anion, accordingly LDH possesses high affinity to upload the drug anions and form ordered structure.…”

“…Bingxin et al (Bingxin at al., 2004) showed that the release of the intercalated NSAID fenbufen from LDH nanocomposites is a slow process, especially in the case of Mg/Al intercalated materials. Recently, we described a new approach of improving drug solubility and absorption in the gastrointestinal track by using LDH nanoparticles as a drug carrier (Berber et al 2008). In this work, the NSAIDs naproxen and flurbiprofen were chosen as models of poorly soluble drugs.…”

Nanocomposite Formulation System of Lipid-Regulating Drugs Based on Layered Double Hydroxide: Synthesis, Characterization and Drug Release Properties

“…Drug-LDH nanohybrid materials have been formulated to control drug release properties, drug solubility and dissolution (13)(14)(15)(16)(17). In addition, the amount of the incorporated drug into LDH has been controlled by changing the composite preparation technique (17). The intercalation of vitamins (18) and nucleic acids (19) into LDH offered a safe preservation of the guest bioactivity without any deterioration of the structural integrity.…”

“…Many kinds of beneficial organic anions have been stacked as guests into the interlayer of LDH, such as drugs, vitamins and nucleic acids. Drug-LDH nanohybrid materials have been formulated to control drug release properties, drug solubility and dissolution (13)(14)(15)(16)(17). In addition, the amount of the incorporated drug into LDH has been controlled by changing the composite preparation technique (17).…”