Nanocolloids of indomethacin prepared using sonication and subsequent encapsulation with polysaccharide films

Milkova, Viktoria; Kamburova, Kamelia; Radeva, Tsetska

doi:10.1016/j.colsurfb.2013.02.024

Cited by 16 publications

(12 citation statements)

References 32 publications

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“…However, small or no differences were observed between the formulations, which suggest that most of the PTX was released within the first 24 h. This is consistent with the release profiles obtained in sink conditions (Figure d). Importantly, there was no additional toxicity induced by the presence of the multilayer polyelectrolyte shell, which is in line with what has been reported for other multilayer encapsulated drug nanocores . Moreover, red blood cells (RBCs) exposed to both Abraxane and NC/PSS 70 (PLR/PSS 17 ) 3 ‐PEG (at PTX concentrations similar to those present in the blood after i.v.…”

Section: Resultssupporting

confidence: 85%

In Vitro and In Vivo Evaluation of PEGylated Layer‐by‐Layer Polyelectrolyte‐Coated Paclitaxel Nanocrystals

Połomska

Gauthier

Leroux

2016

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Drug nanocrystals (NCs) are colloidal dispersions composed almost entirely of drug. As such, there is substantial interest in targeting them to diseased tissues, where they can locally deliver high doses of the therapeutic. However, because of their uncontrolled dissolution characteristics in vivo and uptake by the monomolecular phagocyte system, achieving tumor accumulation is challenging. To address these issues, a layer-by-layer approach is adopted to coat paclitaxel NCs with alternating layers of oppositely charged polyelectrolytes, using a PEGylated copolymer as the top layer. The coating successfully slows down dissolution in comparison to the noncoated NCs and to Abraxane (an approved paclitaxel nanoformulation), provides colloidal stability in physiologically relevant media, and has no intrinsic effect on cell viability at the concentrations tested. Nevertheless, their pharmacokinetic and biodistribution profile indicates that the NCs are rapidly cleared from the bloodstream followed by accumulation in the mononuclear phagocyte system organs (i.e., liver and spleen). This is hypothesized to be a consequence of the shedding of the PEGylated polyelectrolyte from the NCs' surface. While therapeutic efficacy was not investigated (due to poor tumor accumulation), overall, this work questions whether approaches that rely solely on electrostatic interactions for retaining coatings on the surfaces of NCs are appropriate for use in vivo.

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Section: Resultssupporting

confidence: 85%

In Vitro and In Vivo Evaluation of PEGylated Layer‐by‐Layer Polyelectrolyte‐Coated Paclitaxel Nanocrystals

Połomska

Gauthier

Leroux

2016

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“…Similar electrokinetic and stability behavior of oilcore nanocapsules coated by chitosan derivatives at different pH and salt concentration have also been presented in our previous study (11). Recently, we have investigated the influence electrical properties of chitosan on the formation of polyelectrolyte multilayer films on oxide nanoparticles (12)(13)(14). The results demonstrate that the charge density of the chitosan deposited on top of the film defines the electrical properties of the entire polymer-coated particle.…”

Section: Introductionsupporting

confidence: 77%

Electrokinetic behavoir of chitosan adsorbed on o/w nanoemulsion droplets

Goycoolea

Milkova

2017

Colloids and Surfaces A: Physicochemical and Engineering Aspect

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Please cite this article as: Francisco M.Goycoolea, Viktoria Milkova, Electrokinetic behavoir of chitosan adsorbed on o/w nanoemulsion droplets, Colloids and Surfaces A: Physicochemical and Engineering Aspects http://dx.Highlights  Stability of O/W nanoemulsion in the presence of chitosan;  Fraction of condensed counterions released from chitosan molecules upon adsorption on weak charged surface;  Electrical polarizability of chitosan molecule with condensed counterions. AbstractChitosans with different molecular weight and degree of acetylation (DA) were adsorbed onto lecithin stabilized nanoemulsion droplets at pH4.7. The electrokinetic properties of the nanoemulsion were investigated by using dynamic light scattering. According to the experimental data, the isoelectric point (IEP) of the droplets in the suspension at the presence of oppositely charged chitosan, does not depend on the polyelectrolyte molecular weight (when DA of chitosan is lower than 32 %). Due to the high charge density of these polymer chains and low surface charge density of the lecithin stabilized droplets, the chitosan molecules retain part of the condensed counterions upon the adsorption process. Thus, the registered electrophoretic mobility corresponding to the "effective", and not "real", the electrokinetic charge of the droplets covered by a polymer layer. The stability behavior of the nanoemulsion in the presence of chitosan with lower charge density is different, and the IEP and stabilization of the system is achieved at higher polymer concentration. The coincidence in the polyelectrolyte concentration corresponding to IEP and minimum stability of the nanoemulsion against coagulation agrees with the notion that the electrostatic interactions are predominant in the coating layer formation. In spite of the similar electrokinetic behavior of the droplets covered with chitosan with low DA and different molecular weight, the polymers have different biological activity which might be results from different charge density of the molecules. In the present study, we show that the electrical polarizability is a complex parameter that can allow to more detailed characterization of the electrical properties of the chitosan.

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“…Cyclosporine Liposomes (Freise et al, 1994;Shah et al, 2006); polymeric NP (Gref et al, 2001;Italia et al, 2007;Azzi et al, 2010;Tang et al, 2012); lipid NP (Muller et al, 2008) Preclinical Tacrolimus Lipid NP (Pople and Singh, 2012); polymeric NP (Tammam et al, 2012); liposomes (Erdogan et al, 2002;Zhang et al, 2010) Preclinical Rapamycin/sirolimus Polymeric NP (Yuan et al, 2008;Woo et al, 2012;Shah et al, 2013); micelles (Yanez et al, 2008;Chen et al, 2013); liposomes (Rouf et al, 2009;Ghanbarzadeh et al, 2013) Preclinical Mycophenolic acid Polymeric NP (Shirali et al, 2011); nanogels (Look et al, 2013); dendrimers (Hu et al, 2009) Preclinical Corticosteroids Liposomes Linker et al, 2008;Schweingruber et al, 2011;Ulmansky et al, 2012); polymeric NP (Ishihara et al, 2005;Matsuo et al, 2009); solid lipid NP (Jensen et al, 2010;Zhang and Smith, 2011); dendrimers (Khandare et al, 2005) Preclinical Non-steroidal anti-inflammatory Dendrimers (Chauhan et al, 2004;Na et al, 2006;Chandrasekar et al, 2007;Cheng et al, 2007); nanocolloid (Milkova et al, 2013); lipid NP (Castelli et al, 2005); liposomes (Paavola et al, 2000;Srinath et al, 2000;Turker et al, 2008)…”

Section: Nanocarrier Statusmentioning

confidence: 99%

Immunosuppressive and Anti-Inflammatory Properties of Engineered Nanomaterials

Ilinskaya

Dobrovolskaia

2016

Handbook of Immunological Properties of Engineered Nanomaterials

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Nanoparticle interactions with various components of the immune system are determined by their physicochemical properties such as size, charge, hydrophobicity and shape. Nanoparticles can be engineered to either specifically target the immune system or to avoid immune recognition. Nevertheless, identifying their unintended impacts on the immune system and understanding the mechanisms of such accidental effects are essential for establishing a nanoparticle's safety profile. While immunostimulatory properties have been reviewed before, little attention in the literature has been given to immunosuppressive and anti-inflammatory properties. The purpose of this review is to fill this gap. We will discuss intended immunosuppression achieved by either nanoparticle engineering, or the use of nanoparticles to carry immunosuppressive or anti-inflammatory drugs. We will also review unintended immunosuppressive properties of nanoparticles per se and consider how such properties could be either beneficial or adverse. LINKED ARTICLESThis article is part of a themed section on Nanomedicine. To view the other articles in this section visit http://dx

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Nanocolloids of indomethacin prepared using sonication and subsequent encapsulation with polysaccharide films

Cited by 16 publications

References 32 publications

In Vitro and In Vivo Evaluation of PEGylated Layer‐by‐Layer Polyelectrolyte‐Coated Paclitaxel Nanocrystals

In Vitro and In Vivo Evaluation of PEGylated Layer‐by‐Layer Polyelectrolyte‐Coated Paclitaxel Nanocrystals

Electrokinetic behavoir of chitosan adsorbed on o/w nanoemulsion droplets

Immunosuppressive and Anti-Inflammatory Properties of Engineered Nanomaterials

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