Electrokinetic behavoir of chitosan adsorbed on o/w nanoemulsion droplets

Goycoolea, Francisco M.; Milkova, Viktoria

doi:10.1016/j.colsurfa.2016.05.093

Cited by 19 publications

(15 citation statements)

References 36 publications

(37 reference statements)

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“…The panels A–D show the CS distribution as its concentration is increased from 50 CS chains ( Figure 4 A) to 200 CS chains ( Figure 4 D). These maps show that CS is adsorbed over the surface of the nanoliposome, as has been reported in experimental work [ 58 , 59 , 60 ]. It is also possible to see how the surface becomes more homogeneous with increasing CS concentration.…”

Section: Resultssupporting

confidence: 81%

“…This is an encouraging aspect of mesoscale simulation techniques, such as DPD. Additionally, the percentage of capsaicin encapsulation was very close (96%) to that reported experimentally (92%) [ 58 ].…”

Section: Resultssupporting

confidence: 80%

“…The mean size of the simulated nanoliposome is smaller but comparable to those obtained experimentally for CS-coated oil-core nanocapsules (~80–250 nm) [ 18 , 43 , 58 , 59 ]. This is an encouraging aspect of mesoscale simulation techniques, such as DPD.…”

Section: Resultssupporting

confidence: 71%

See 2 more Smart Citations

Mesoscopic Modeling of the Encapsulation of Capsaicin by Lecithin/Chitosan Liposomal Nanoparticles

et al. 2018

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The transport of hydrophobic drugs in the human body exhibits complications due to the low solubility of these compounds. With the purpose of enhancing the bioavailability and biodistribution of such drugs, recent studies have reported the use of amphiphilic molecules, such as phospholipids, for the synthesis of nanoparticles or nanocapsules. Given that phospholipids can self-assemble in liposomes or micellar structures, they are ideal candidates to function as vehicles of hydrophobic molecules. In this work, we report mesoscopic simulations of nanoliposomes, constituted by lecithin and coated with a shell of chitosan. The stability of such structures and the efficiency of the encapsulation of capsaicin, as well as the internal and superficial distribution of capsaicin and chitosan inside the nanoliposome, were analyzed. The characterization of the system was carried out through density maps and the potentials of mean force for the lecithin-capsaicin, lecithin-chitosan, and capsaicin-chitosan interactions. The results of these simulations show that chitosan is deposited on the surface of the nanoliposome, as has been reported in some experimental works. It was also observed that a nanoliposome of approximately 18 nm in diameter is stable during the simulation. The deposition behavior was found to be influenced by a pattern of N-acetylation of chitosan.

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Section: Resultssupporting

confidence: 81%

Section: Resultssupporting

confidence: 80%

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Mesoscopic Modeling of the Encapsulation of Capsaicin by Lecithin/Chitosan Liposomal Nanoparticles

et al. 2018

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“…EE is obtained from the following equation: EE = ((CapsT À CapsF)/CapsT) Â 100, where CapsT is the total concentration of capsaicin in the system and CapsF is the free capsaicin in solution. The percentage of EE for the capsaicin obtained in this work was of 96%, which is very close to that reported experimentally of 92% [48], besides, is very similar to the obtained percentage in our previous study, where the presence of chitosan polymer was included [31].…”

Section: Exploring Self-assembly Of Capsaicin By Lecithin Nanoliposomessupporting

confidence: 91%

Dissipative Particle Dynamics Simulations of Self-Assemblies of Liposomes for Drug Delivery Applications

Terrón-Mejía¹,

Higuera‐Ciapara²,

Martínez-Benavidez³

et al. 2019

Liposomes - Advances and Perspectives

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Liposomes are essential components in the development of functional materials for drug delivery; this is mainly due to its ability to self-associate spontaneously and form bilayer vesicles. In these potential applications, knowing the size of selfassembled liposomes is essential for optimal performance; however, this process still has many unanswered questions. Conventional experimental techniques to study self-assemblies of liposome nanoparticles still have a great challenge. Computational simulations emerge as an alternative to understand the role of thermodynamic properties responsible for the self-assembly, particularly when they are unreachable experimentally because of limited time and length resolutions. In this chapter, we present the advantages and disadvantages of dissipative particle dynamic method to explore the functioning of liposome self-assembly in the transport of drugs.

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“…The density maps corresponding to CS are shown in Figure 4. These maps show that CS is adsorbed over the surface of the nanoliposome, as has been reported in experimental work [50][51][52]. It is also possible to see how the surface becomes more homogeneous with increasing CS concentration.…”

Section: Distribution Of Chitosan On Liposomesupporting

confidence: 76%

Mesoscopic Modeling of Encapsulation of Capsaicin by Lecithin/Chitosan Liposomal Nanoparticles

Terrón-Mejía¹,

Martínez-Benavidez²,

Higuera‐Ciapara³

et al. 2018

Preprint

Self Cite

View full text Add to dashboard Cite

Transport of hydrophobic drugs in the human body exhibits complications due to the low solubility of these compounds. With the purpose of enhancing the bioavailability and biodistribution of such drugs, recent studies have reported the use of amphiphilic molecules, such as phospholipids, for synthesis of nanoparticles or nanocapsules. Given that phospholipids can self–assemble in liposomes or micellar structures, they are ideal candidates to function as vehicles of hydrophobic molecules. In this work, we report mesoscopic simulations of nanoliposomes, constituted by lecithin and coated with a shell of chitosan. The stability of such structure and the efficiency of encapsulation of capsaicin, as well as the internal and superficial distribution of capsaicin and chitosan inside the nanoliposome were analyzed. The characterization of the system was carried out through density maps and the potentials of mean force for the lecithin–capsaicin, lecithin–chitosan and capsaicin–chitosan interactions. The results of these simulations show that chitosan is deposited on the surface of the nanoliposome, as has been reported in some experimental works. It was also observed that a nanoliposome of approximately 18 nm in diameter is stable during the simulation. The deposition behavior was found to be influenced by pattern of N-acetylation of chitosan.

show abstract

Electrokinetic behavoir of chitosan adsorbed on o/w nanoemulsion droplets

Cited by 19 publications

References 36 publications

Mesoscopic Modeling of the Encapsulation of Capsaicin by Lecithin/Chitosan Liposomal Nanoparticles

Mesoscopic Modeling of the Encapsulation of Capsaicin by Lecithin/Chitosan Liposomal Nanoparticles

Dissipative Particle Dynamics Simulations of Self-Assemblies of Liposomes for Drug Delivery Applications

Mesoscopic Modeling of Encapsulation of Capsaicin by Lecithin/Chitosan Liposomal Nanoparticles

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