Nanoceria: Metabolic interactions and delivery through PLGA-encapsulation

Mehta, Apoorva; Scammon, Bradley; Shrake, Kevin; Bredikhin, Mikhail; Gil, Dmitry; Шекунова, Т. О.; Baranchikov, А. Е.; Иванов, В. К.; Reukov, Vladimir

doi:10.1016/j.msec.2020.111003

Cited by 15 publications

(11 citation statements)

References 22 publications

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“…In a different study, Mehta et al [167] fabricated PLGA MPs containing nanoceria and ROS-scavenging enzymes, either catalase or SOD, using a previously reported one-stage method [168]. These PLGA MPs are expected to showcase a synergistic effect with the enzymes and were synthesized via a standard double emulsion method [80], where the encapsulants (nanoceria and SOD) were dispersed together with PLGA in the organic phase [167].…”

Section: Other Plga/inorganic-np-based Compositesmentioning

confidence: 99%

“…In a different scenario, PLGA/INP nanocomposites were shown to reduce ROS and counteract oxidative stress. In the work of Mehta et al [167] PLGA MPs were used to encapsulate cerium oxide NPs (nanoceria-CNPs) together with SOD and catalase enzymes. Both the organic and the inorganic part of the system act synergistically to help prevent oxidative stress by scavenging ROS.…”

Section: Therapymentioning

confidence: 99%

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PLGA-Based Composites for Various Biomedical Applications

Rocha

Gonçalves

Silva

et al. 2022

IJMS

135

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Polymeric materials have been extensively explored in the field of nanomedicine; within them, poly lactic-co-glycolic acid (PLGA) holds a prominent position in micro- and nanotechnology due to its biocompatibility and controllable biodegradability. In this review we focus on the combination of PLGA with different inorganic nanomaterials in the form of nanocomposites to overcome the polymer’s limitations and extend its field of applications. We discuss their physicochemical properties and a variety of well-established synthesis methods for the preparation of different PLGA-based materials. Recent progress in the design and biomedical applications of PLGA-based materials are thoroughly discussed to provide a framework for future research.

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Section: Other Plga/inorganic-np-based Compositesmentioning

confidence: 99%

Section: Therapymentioning

confidence: 99%

PLGA-Based Composites for Various Biomedical Applications

Rocha

Gonçalves

Silva

et al. 2022

IJMS

135

View full text Add to dashboard Cite

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“…Mehta and colleagues developed microcarriers for encapsulating both nanoceria and metabolic enzymes, namely superoxide dismutase (SOD), using biocompatible and biodegradable poly(lactic-co-glycolic acid) (PLGA) [ 76 ]. Cellular uptake studies were conducted, along with a cytotoxicity assay.…”

Section: Ceria Additives Improving Implants’ Biodegradabilitymentioning

confidence: 99%

“…The antioxidative properties of PLGA-nanoceria-SOD particles were confirmed by adding H 2 O 2 to cell culture and imaging with fluorescent markers of oxidative stress. The results obtained suggested that PLGA is a suitable encapsulating carrier for the simultaneous delivery of nanoceria and SOD together, and that this combination effectively reduces oxidative stress in vitro [ 76 ]. Aliphatic polyesters such as polylactide (PLA), poly(glycolides) (PGA) and poly(ɛ-caprolactone) (PCL) possess high biodegradability and biocompatibility [ 103 ].…”

Section: Ceria Additives Improving Implants’ Biodegradabilitymentioning

confidence: 99%

“…Aliphatic polyesters such as polylactide (PLA), poly(glycolides) (PGA) and poly(ɛ-caprolactone) (PCL) possess high biodegradability and biocompatibility [ 103 ]. The tunable degradation of poly(lactic- co -glycolic acid) (PLGA) makes it a candidate material for the encapsulation and delivery of active substances and drugs (for example, for SOD protecting by CeNPs [ 76 ]). Conversely, polyurethanes (PU) are slowly degradable or completely lack degradability.…”

Section: Ceria Additives Improving Implants’ Biodegradabilitymentioning

confidence: 99%

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CeO2 Nanoparticle-Containing Polymers for Biomedical Applications: A Review

et al. 2021

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The development of advanced composite biomaterials combining the versatility and biodegradability of polymers and the unique characteristics of metal oxide nanoparticles unveils new horizons in emerging biomedical applications, including tissue regeneration, drug delivery and gene therapy, theranostics and medical imaging. Nanocrystalline cerium(IV) oxide, or nanoceria, stands out from a crowd of other metal oxides as being a truly unique material, showing great potential in biomedicine due to its low systemic toxicity and numerous beneficial effects on living systems. The combination of nanoceria with new generations of biomedical polymers, such as PolyHEMA (poly(2-hydroxyethyl methacrylate)-based hydrogels, electrospun nanofibrous polycaprolactone or natural-based chitosan or cellulose, helps to expand the prospective area of applications by facilitating their bioavailability and averting potential negative effects. This review describes recent advances in biomedical polymeric material practices, highlights up-to-the-minute cerium oxide nanoparticle applications, as well as polymer-nanoceria composites, and aims to address the question: how can nanoceria enhance the biomedical potential of modern polymeric materials?

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Nanodrugs with intrinsic radioprotective exertion: Turning the double‐edged sword into a single‐edged knife

Guo¹,

Zhao

Shang

et al. 2023

Exploration

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Ionizing radiation (IR) poses a growing threat to human health, and thus ideal radioprotectors with high efficacy and low toxicity still receive widespread attention in radiation medicine. Despite significant progress made in conventional radioprotectants, high toxicity, and low bioavailability still discourage their application. Fortunately, the rapidly evolving nanomaterial technology furnishes reliable tools to address these bottlenecks, opening up the cutting‐edge nano‐radioprotective medicine, among which the intrinsic nano‐radioprotectants characterized by high efficacy, low toxicity, and prolonged blood retention duration, represent the most extensively studied class in this area. Herein, we made the systematic review on this topic, and discussed more specific types of radioprotective nanomaterials and more general clusters of the extensive nano‐radioprotectants. In this review, we mainly focused on the development, design innovations, applications, challenges, and prospects of the intrinsic antiradiation nanomedicines, and presented a comprehensive overview, in‐depth analysis as well as an updated understanding of the latest advances in this topic. We hope that this review will promote the interdisciplinarity across radiation medicine and nanotechnology and stimulate further valuable studies in this promising field.

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Nanoceria: Metabolic interactions and delivery through PLGA-encapsulation

Cited by 15 publications

References 22 publications

PLGA-Based Composites for Various Biomedical Applications

PLGA-Based Composites for Various Biomedical Applications

CeO2 Nanoparticle-Containing Polymers for Biomedical Applications: A Review

Nanodrugs with intrinsic radioprotective exertion: Turning the double‐edged sword into a single‐edged knife

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