Nanobiotechnology and its applications in drug delivery system: a review

Khan, Imran; Khan, Momin; Umar, Muhammad Naveed; Oh, Deog‐Hwan

doi:10.1049/iet-nbt.2014.0062

Cited by 73 publications

(56 citation statements)

References 67 publications

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“…Chitosan is a naturally obtained biopolymer and has many applications in the food industry (Khan & Deog‐Hwan, ; Khan et al ., ). It has been considered as generally recognized as safe (GRAS) by the United States Food and Drug Administration (USFDA) (USFDA, ) and has shown broad spectrum antimicrobial potential against both Gram‐negative and Gram‐positive bacteria as well as fungi (Chounou et al ., ).…”

Section: Introductionmentioning

confidence: 99%

Development and evaluation of chitosan and its derivative for the shelf life extension of beef meat under refrigeration storage

Khan

Tango

2017

Int J of Food Sci Tech

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Summary The current study was aimed to study the shelf life of beef meat at refrigeration storage using novel chitosan derivative (Ch‐D). Chitosan was modified with antimicrobial monomethyl fumaric acid (MFA). The chemical structure of the resulting material was characterized by FT‐IR and HR‐XRD. The results confirmed the successful synthesis of conjugate sample. For the shelf life study, following lots were used: control (distilled water), chitosan 0.5%, Ch‐D 0.5%. The samples were kept at 4 °C for 16 days and analyzed at 4‐day intervals. Ch‐D treatment significantly reduced the total viable counts, enterobacteriaceae, lactic acid bacteria, psychrotrophic bacteria, and yeasts–moulds when compared with the chitosan and control during refrigeration storage. The peroxide value (PV) for Ch‐D was 0.19 ± 0.04 meq O2 kg−1 fat and chitosan was 0.21 ± 0.07 meq O2 kg−1 fat and showed no significant difference (P < 0.05) at the end of the storage. Thiobarbituric acid reactive substance (TBARs) value for Ch‐D was 0.48 ± 0.02 mg MDA kg−1 and chitosan was 0.57 ± 0.09 mg MDA kg−1, while the carbonyl contents for Ch‐D was 3.16 ± 0.23 nm mg−1 protein and chitosan was 3.11 ± 0.16 nm mg−1 protein at 16 days of storage. Values for Ch‐D and chitosan treatments were significantly lower (P < 0.05) for all the quality attributes as compared with the control throughout storage. At the end of storage, Ch‐D treatment showed a significant increase (P < 0.05) in lightness (L* = 41.54 ± 0.09) and yellowness (b* = 2.23 ± 0.04). The redness for control was high (a* = 6.12 ± 0.09) as compared with the treated samples. Based primarily on microbial counts, Ch‐D treatment extended the shelf life of beef meat by about 8 days, maintaining acceptable quality attributes.

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Section: Introductionmentioning

confidence: 99%

Development and evaluation of chitosan and its derivative for the shelf life extension of beef meat under refrigeration storage

Khan

Tango

2017

Int J of Food Sci Tech

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“…Research over the last decade has highlighted the significance of bioavailability for lipophilic drugs and much attention has been given to developing drug delivery platforms for improving the bioavailability and efficiency of poorly water-soluble compounds [17][18][19]. Given that, TPs and TCs are potent antioxidants, but lipid soluble, it is intriguing whether their bioavailability difference could be affecting their tissue response.…”

Section: Introductionmentioning

confidence: 99%

Effects of nano-emulsion preparations of tocopherols and tocotrienols on oxidative stress and osteoblast differentiation

Song

Zhang

Wang

et al. 2017

ARCH BIOL SCI BELGRA

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Tocopherols and tocotrienols are two groups of compounds in the vitamin E family, of which the tocopherols are widely used as antioxidant dietary supplements. Recent studies have shown mixed observations for tocopherol functions in bone homeostasis. We have evaluated the potency of suspension-and nano-emulsion formulation-based delivery of different vitamin E family members in lipopolysaccharide (LPS)-induced oxidative stress and osteoblast differentiation. Our results showed the both tocopherols and tocotrienols could reduce oxidative stress as evaluated by the levels of reactive oxygen species (ROS). Their effects were enhanced when applied in the nano-emulsion mode of delivery due to increased bioavailability. In addition, our results showed that tocotrienols increased osteoblast differentiation, while tocopherols showed reduced osteoblast differentiation, which may be due to their differential effects on SMAD and p65 signaling. Together, these findings indicate that tocotrienols delivered through nano-emulsion exhibit superior antioxidant properties and osteoblast differentiation, and could serve as a better alternative to tocopherol-based vitamin E supplements.

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“…An ideally designed nanoparticulate system, with size range of 50–200 nm, can provided prolonged circulation time, efficiently translocate across cellular membranes and unload encapsulated actives at desired site in a programmed manner to minimize off‐target adverse effects. Further, the innovative materials with varied chemical make‐up employed in fabrication of nanoparticles allow encapsulation of drugs and diagnostic agents with diverse physicochemical properties …”

Section: Applications Of 3d Cell Culturementioning

confidence: 99%

“…[145][146][147] An ideally agents with diverse physicochemical properties. 148,149 Despite such substantial and alluring advantages that nanoparticulate carrier systems have to offer, the "bench-to-bedside" transition of these nanotechnology based formulations has remained very limited so far. 150 The scope of microfluidic technology for consistent bulk manufacturing of nanoparticles has been well recognized.…”

Section: D Tissue Models For Nanoparticles' Development and Characmentioning

confidence: 99%

Microfluidics‐based 3D cell culture models: Utility in novel drug discovery and delivery research

Gupta¹,

Liu²,

Patel³

et al. 2016

Bioengineering & Transla Med

183

146

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The implementation of microfluidic devices within life sciences has furthered the possibilities of both academic and industrial applications such as rapid genome sequencing, predictive drug studies, and single cell manipulation. In contrast to the preferred two‐dimensional cell‐based screening, three‐dimensional (3D) systems have more in vivo relevance as well as ability to perform as a predictive tool for the success or failure of a drug screening campaign. 3D cell culture has shown an adaptive response to the recent advancements in microfluidic technologies which has allowed better control over spheroid sizes and subsequent drug screening studies. In this review, we highlight the most significant developments in the field of microfluidic 3D culture over the past half‐decade with a special focus on their benefits and challenges down the lane. With the newer technologies emerging, implementation of microfluidic 3D culture systems into the drug discovery pipeline is right around the bend.

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Nanobiotechnology and its applications in drug delivery system: a review

Cited by 73 publications

References 67 publications

Development and evaluation of chitosan and its derivative for the shelf life extension of beef meat under refrigeration storage

Development and evaluation of chitosan and its derivative for the shelf life extension of beef meat under refrigeration storage

Effects of nano-emulsion preparations of tocopherols and tocotrienols on oxidative stress and osteoblast differentiation

Microfluidics‐based 3D cell culture models: Utility in novel drug discovery and delivery research

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