Nano-patterned SERS substrate: Application for protein analysis vs. temperature

Das, Gobind; Mecarini, Federico; Gentile, Francesco; Angelis, Francesco De; Kumar, HG Mohan; Candeloro, Patrizio; Liberale, Carlo; Cuda, Giovanni; Fabrizio, E. Di

doi:10.1016/j.bios.2008.08.050

Cited by 220 publications

(136 citation statements)

References 33 publications

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“…These benefit from multiple hot spots being generated in a uniform fashion over a larger substrate area generating high signal enhancement 22 throughout the entire substrate. Various methods exist to fabricate such structures including lithographic 18,23,24 and chemical approaches 19 . Metallic structures can also be fabricated from self assembled non-metallic scaffolds 25 .…”

Section: Introductionmentioning

confidence: 99%

Self-assembled nanoparticle arrays for multiphase trace analyte detection

et al. 2012

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Nanoplasmonic structures designed for trace analyte detection by surface enhanced Raman spectroscopy typically require sophisticated nanofabrication techniques. An alternative to fabricating such arrays is to rely on self-assembly of nanoparticles at liquid-liquid or liquid-air interfaces into close-packed arrays.The density of the arrays can be fine tuned by modifying the nanoparticle functionality, pH of the solution, and salt concentration. Importantly, these arrays are robust, "self-healing", reproducible, and extremely easy to handle. Herein, we report on the use of such platforms made of Au nanoparticles for detection of (multi)analytes from the aqueous, organic, or air phases. The total interfacial area of the Au array, at the liquid-liquid interface, is approximately 25 mm 2 , making this platform ideal for small volume samples, low concentrations, and trace analytes. Importantly, the ease of assembly and rapid 2 detection makes this platform ideal for in-field sample testing of toxins such as explosives, drugs, or other hazardous chemicals.3

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Section: Introductionmentioning

confidence: 99%

Self-assembled nanoparticle arrays for multiphase trace analyte detection

et al. 2012

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“…In the close proximity of metal nanoclusters, field enhancement occurs because of the resonant interaction between the optical fields and surface plasmons in the metal [51][52][53]. In essence, the light from a laser beam excites the surface plasmons, which are collective oscillations of conduction electrons.…”

Section: Discussionmentioning

confidence: 99%

The Five Ws (and one H) of Super-Hydrophobic Surfaces in Medicine

et al. 2014

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Super-hydrophobic surfaces (SHSs) are bio-inspired, artificial microfabricated interfaces, in which a pattern of cylindrical micropillars is modified to incorporate details at the nanoscale. For those systems, the integration of different scales translates into superior properties, including the ability of manipulating biological solutions. The five Ws, five Ws and one H or the six Ws (6W), are questions, whose answers are considered basic in information-gathering. They constitute a formula for getting the complete story on a subject. According to the principle of the six Ws, a report can only be considered complete if it answers these questions starting with an interrogative word: who, why, what, where, when, how. Each question should have a factual answer. In what follows, SHSs and some of the most promising applications thereof are reviewed following the scheme of the 6W. We will show how these surfaces can be integrated into bio-photonic devices for the identification and detection of a single molecule. We will describe how SHSs and nanoporous silicon matrices can be combined to yield devices with the capability of harvesting small molecules, where the cut-off size can be adequately controlled. We will describe how this concept is utilized for obtaining a direct TEM image of a DNA molecule. OPEN ACCESSMicromachines 2014, 5 240

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“…Fortunately, plasmonic nanostructures can strongly improve the Raman effect, with enhancing factors up to 10 12 [35], and producing the well-known SERS effect (Surface Enhanced Raman Scattering). Then, the integration of plasmonic nanosensors into microfluidic devices will circumvent the issue of small Raman scattering cross-section, and will accomplish a valid tool for label-free biochemical analysis in microfluidic environment (Figure 4c).…”

Section: Screening Of Cells By Label-free Plasmonic Sensors Integratementioning

confidence: 99%

Optofluidics for handling and analysis of single living cells

Perozziello¹,

Candeloro²,

Coluccio³

et al. 2017

Optofluidics, Microfluidics and Nanofluidics

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Abstract:Optofluidics is a field with important applications in areas such as biotechnology, chemical synthesis and analytical chemistry. Optofluidic devices combine optical elements into microfluidic devices in ways that increase portability and sensitivity of analysis for diagnostic or screening purposes .In fact in these devices fluids give fine adaptability, mobility and accessibility to nanoscale photonic devices which otherwise could not be realized using conventional devices. This review describes several cases in which optical or microfluidic approaches are used to trap single cells in proximity of integrated optical sensor for being analysed.

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Nano-patterned SERS substrate: Application for protein analysis vs. temperature

Cited by 220 publications

References 33 publications

Self-assembled nanoparticle arrays for multiphase trace analyte detection

Self-assembled nanoparticle arrays for multiphase trace analyte detection

The Five Ws (and one H) of Super-Hydrophobic Surfaces in Medicine

Optofluidics for handling and analysis of single living cells

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