Nano-Metal–Organic Framework Decorated With Pt Nanoparticles as an Efficient Theranostic Nanoprobe for CT/MRI/PAI Imaging-Guided Radio-Photothermal Synergistic Cancer Therapy

Abstract

The multifunctional theranostic nanoplatforms, which can realize changing the contrasts of medical images and enhance cancer therapies simultaneously, have attracted tremendous attention from chemists and medicine in past decades. Herein, a nanoscale metal–organic framework-based material was first synthesized and then decorated with platinum (NMOF545@Pt) successfully for multimodal imaging-guided synergistic cancer therapy. The obtained NMOF545@Pt is advantageous in shortening the longitudinal relaxation time (T1), enhancing photoacoustic effects, and elevating X-ray absorption efficiently. Thus, the enchantments of tripe imaging modalities, computed tomography (CT)/magnetic resonance imaging (MRI)/photoacoustic imaging (PAI), were realized with NMOF545@Pt administration simultaneously and can be cleared from the mice. Meanwhile, in vitro and in vivo experiments demonstrate that the synthesized NMOF545@Pt can dramatically increase photothermal therapy (PTT) and radiotherapy (RT) efficacy. Convincing evidence proves that tumor growth can be wholly inhibited without noticeable side effects or organ damage. The results demonstrated the promise of multifunctional nanocomposites NMOF545@Pt to improve biomedical imaging and synergistic tumor treatments.

Recent progress and challenges of MOF-based nanocomposites in bioimaging, biosensing and biocarriers for drug delivery

“…2b. In a study by Ma et al, 69 the NMOF545@Pt synthesized from HfCl 4 , Mn-TCPP, and H 2 PtCl 6 exhibited a CT value of 110 HU, surpassing the MOF synthesized by Bao et al 64 The higher concentration of Pt (Z = 78) in this study may inuence signal enhancement in CT. Additionally, this study highlights NMOF545/Pt as a potential contrast agent for MRI/ CT/PAI imaging modalities, showcasing its promising role in diagnostic imaging technology. Similarly, You et al 63 fabricated a MOF-based therapeutic system integrating modalities such as CT, MRI, and FL for precise cancer chemotherapy.…”

Platinum based theranostics nanoplatforms for antitumor applications

“…Currently, most MRI nanoplatforms use chelating agents that can reduce both T 1 and T 2 relaxation times, such as Fe 3 O 4 or Gd 3+ . In addition, combining the CT imaging ability of Pt element, such as the Pt-modified nanomaterial NMOF545@Pt 88 synthesized by Ma et al In this composite material, the manganese( iii ) porphyrin is beneficial for shortening the longitudinal relaxation time, which can obtain T 1 -weighted MRI images, while the high atomic cluster effect of Pt can weaken X-ray penetration and enhance the quality of CT images. Furthermore, the platinum-based nanomedicine platform can also enhance the photoacoustic effects (Fig.…”