Nano‐curcumin safely prevents streptozotocin‐induced inflammation and apoptosis in pancreatic beta cells for effective management of Type 1 diabetes mellitus

Ganugula, Raghu; Arora, Meenakshi; Jaisamut, Patcharawalai; Wiwattanapatapee, Ruedeekorn; Jørgensen, Heather G.; Venkatpurwar, Vinod; Zhou, Beiyan; Hoffmann, Aline Rodrigues; Basu, Rita; Guo, Shaodong; Kumar, M. N. V. Ravi

doi:10.1111/bph.13816

Cited by 86 publications

(78 citation statements)

References 44 publications

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“…Pre-treatment of STZ-induced, diabetic, Sprague-Dawley rats with nanosystems encapsulating curcumin (nCurcumin; 50 mg/kg b.w./day) for 28 days resulted in reduced serum glucose levels and increased insulin levels, indicating reduced hyperglycemia [49]. Pancreatic islet cell death was significantly reduced with nCurcumin pre-treatment.…”

Section: Streptozotocin (Stz)-induced Diabetes Modelmentioning

confidence: 99%

“…Pancreatic islet cell death was significantly reduced with nCurcumin pre-treatment. In addition, pancreatic, pro-inflammatory cytokine (IL-1α, granulocyte-colony stimulating factor (G-CSF), IL-10, IL-17A, IL-1β, IL-6, TNF-α, IL-4, granulocyte-macrophage colony stimulating factor (GM-CSF), interferon gamma (IFN-γ), IL-2, IL-5, IL-13 and IL-12p70) levels and pancreatic 8-oxo-dG levels were reduced with nCurcumin pre-treatment, suggesting reduced pro-inflammatory cytokine-induced apoptosis [49].…”

Section: Streptozotocin (Stz)-induced Diabetes Modelmentioning

confidence: 99%

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Antidiabetic Properties of Curcumin II: Evidence from In Vivo Studies

2019

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Type 2 diabetes mellitus (T2DM) is a growing metabolic disease characterized by insulin resistance and hyperglycemia. Current preventative and treatment approaches to insulin resistance and T2DM lack in efficacy, resulting in the need for new approaches to prevent and treat the disease. In recent years, epidemiological studies have suggested that diets rich in fruits and vegetables have beneficial health effects, including protection against insulin resistance and T2DM. Curcumin, a polyphenol found in turmeric, and curcuminoids have been reported to have antioxidant, anti-inflammatory, hepatoprotective, nephroprotective, neuroprotective, immunomodulatory and antidiabetic properties. The current review (II of II) summarizes the existing in vivo studies examining the antidiabetic effects of curcumin.

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Section: Streptozotocin (Stz)-induced Diabetes Modelmentioning

confidence: 99%

Section: Streptozotocin (Stz)-induced Diabetes Modelmentioning

confidence: 99%

Antidiabetic Properties of Curcumin II: Evidence from In Vivo Studies

2019

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“…Recent studies have illustrated that Cur possessed a variety of properties, such as anti-oxidant, anti-inflammation, anti-tumor, anti-viral, anti-bacterial, and had a potential against various disease, i.e. arthritis, allergies, diabetes, AD, and other chronic diseases (Perrone et al., 2015 ; Ganugula et al., 2017 ; Stanic, 2017 ). Cur targets the two histological markers of AD, amyloid beta (Aβ), and tau.…”

Section: Introductionmentioning

confidence: 99%

Curcumin-loaded PLGA-PEG nanoparticles conjugated with B6 peptide for potential use in Alzheimer’s disease

et al. 2018

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Alzheimer’s disease is a neurodegenerative disorder mainly characterized by β-amyloid deposit and tau hyperphosphorylation with no curative treatments. Curcumin (Cur) has been proved to have potential use in Alzheimer’s disease with its anti-amyloid, anti-inflammatory, and anti-oxidant properties, etc. However, its hydrophobicity and low bioavailability hinder its application. In this paper, we designed a novel brain-target nanoparticle, poly(lactide-co-glycolide)-block-poly(ethylene glycol) (PLGA-PEG) conjugated with B6 peptide and was loaded with Cur (PLGA-PEG-B6/Cur) and administered it into HT22 cells and APP/PS1 Al transgenic mice. The in vitro assays including dynamic light scattering (DLS), flow cytometry (FCM), red blood cell (RBC) lysis, and thromboelastography (TEG) analysis indicated that this nanoparticle could narrow the diameter of Cur, increase its cellular uptake and possess good blood compatibility. The results from Morris water maze proved that PLGA-PEG-B6/Cur could tremendously improve the spatial learning and memory capability of APP/PS1 mice, compared with native Cur. The ex vivo assays including Bielschowsky silver staining, immunostaining, and western blotting demonstrated that PLGA-PEG-B6/Cur could reduce hippocampal β-amyloid formation and deposit and tau hyperphosphorylation. Thus, we suggested that PLGA-PEG-B6/Cur nanoparticles would be of potential and promising use for the treatment of Alzheimer’s disease.

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“…A BJP paper provided evidence that biodegradable nanosystem encapsulation have the potential to better translate to humans. Ganugula et al, 2017 T A B L E 2 Acceptance rate of natural product papers in BJP Note: Submissions citing the keyword 'natural product' and their acceptance rate in BJP since 2014 in comparison with overall submission and acceptance. In 2016, BJP began an international initiative to increase awareness of the need for natural product research to adhere to the highest standards of pharmacological research.…”

Section: Papers Describing Novel Formulations For Dietary Supplement mentioning

confidence: 99%

A practical guide for transparent reporting of research on natural products in the British Journal of Pharmacology: Reproducibility of natural product research

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et al. 2020

British J Pharmacology

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Nano‐curcumin safely prevents streptozotocin‐induced inflammation and apoptosis in pancreatic beta cells for effective management of Type 1 diabetes mellitus

Abstract: Together, these data indicate a potentially translatable dose of nCUR that is safe and efficacious in improving beta cell function, which could prevent T1DM.

Cited by 86 publications

References 44 publications

Antidiabetic Properties of Curcumin II: Evidence from In Vivo Studies

Antidiabetic Properties of Curcumin II: Evidence from In Vivo Studies

Curcumin-loaded PLGA-PEG nanoparticles conjugated with B6 peptide for potential use in Alzheimer’s disease

A practical guide for transparent reporting of research on natural products in the British Journal of Pharmacology: Reproducibility of natural product research

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