A practical guide for transparent reporting of research on natural products in the <i>British Journal of Pharmacology</i>: Reproducibility of natural product research

Izzo, Angelo A.; Teixeira, Mauro Martins; Alexander, Stephen P.H.; Cirino, Giuseppe; Docherty, James R.; George, Christopher H.; Insel, Paul A.; Ji, Yong; Kendall, David A.; Panattieri, Reynold A; Sobey, Christopher G.; Stanford, S Clare; Stefańska, Barbara; Stephens, Gary J.; Ahluwalia, Amrita

doi:10.1111/bph.15054

Cited by 185 publications

(182 citation statements)

References 58 publications

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“…The authors have also taken into account the guidelines for best practice in natural products pharmacological research (Heinrich et al, 2020;Izzo et al, 2020).…”

Section: Experimental Methodologymentioning

confidence: 99%

The common diabetes drug metformin can diminish the action of citral against Rhabdomyosarcoma cells in vitro

Duan

Evison

Taylor

et al. 2020

Phytotherapy Research

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Rhabdomyosarcoma (RMS) is a rare type of soft tissue sarcoma most commonly found in pediatric patients. Despite progress, new and improved drug regimens are needed to increase survival rates. Citral, a natural product plant oil can induce cell death in cancer cells. Another compound, metformin, isolated originally from French lilac and used by diabetics, has been shown to reduce the incidence of cancer in these patients. Application of citral to RMS cells showed increase in cell death, and RD and RH30 cells showed half maximal inhibitory concentration (IC50) values as low as 36.28 μM and 62.37 μM, respectively. It was also shown that the citral initiated cell apoptosis through an increase in reactive oxygen species (ROS) and free calcium. In comparison, metformin only showed moderate cell death in RMS cell lines at a very high concentration (1,000 μM). Combinatorial experiments, however, indicated that citral and metformin worked antagonistically when used together. In particular, the ability of metformin to quench the ROS induced by citral could lead to the suppression of activity. These results clearly indicate that while clinical use of citral is a promising anti‐tumor therapy, caution should be exercised in patients using metformin for diabetes.

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“…The authors have also taken into account the guidelines for best practice in natural products pharmacological research (Heinrich et al, 2020;Izzo et al, 2020).…”

Section: Experimental Methodologymentioning

confidence: 99%

The common diabetes drug metformin can diminish the action of citral against Rhabdomyosarcoma cells in vitro

Duan

Evison

Taylor

et al. 2020

Phytotherapy Research

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“…Other critical issues to be considered are the limited quality of some pharmacological reviewed studies that compromises the reliability of the obtained results, and the lack clinical evidence. According to the suggested best practices to be applied in phytopharmacological research [ 288 , 289 ], detailed methodologies, including information about the compound purity, choice of the tested concentrations, experimental procedures, vehicle effects, and comparison with positive controls are recommended. Moreover, promising preclinical results should be confirmed in clinical trials, and possible toxicological concerns and food/drug interactions should be assessed.…”

Section: Open Challenges and Future Directionsmentioning

confidence: 99%

Chemopreventive Potential of Caryophyllane Sesquiterpenes: An Overview of Preliminary Evidence

Sotto

Mancinelli

Gullì

et al. 2020

Cancers

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Chemoprevention is referred to as a strategy to inhibit, suppress, or reverse tumor development and progression in healthy people along with high-risk subjects and oncologic patients through using pharmacological or natural substances. Numerous phytochemicals have been widely described in the literature to possess chemopreventive properties, although their clinical usefulness remains to be defined. Among them, caryophyllane sesquiterpenes are natural compounds widely occurring in nature kingdoms, especially in plants, fungi, and marine environments. Several structures, characterized by a common caryophyllane skeleton with further rearrangements, have been identified, but those isolated from plant essential oils, including β-caryophyllene, β-caryophyllene oxide, α-humulene, and isocaryophyllene, have attracted the greatest pharmacological attention. Emerging evidence has outlined a complex polypharmacological profile of caryophyllane sesquiterpenes characterized by blocking, suppressing, chemosensitizing, and cytoprotective properties, which suggests a possible usefulness of these natural substances in cancer chemoprevention for both preventive and adjuvant purposes. In the present review, the scientific knowledge about the chemopreventive properties of caryophyllane sesquiterpenes and the mechanisms involved have been collected and discussed; moreover, possible structure–activity relationships have been highlighted. Although further high-quality studies are required, the promising preclinical findings and the safe pharmacological profile encourage further studies to define a clinical usefulness of caryophyllane sesquiterpenes in primary, secondary, or tertiary chemoprevention.

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“…According to previous stated critical issues [ 224 , 225 ], herbal products under study must be characterized for the phytochemical composition, using validated analytical methodologies, and for the extraction procedures; moreover, the starting material should be fully defined in terms of origin (country and region), cultivation conditions, botanical identity and plant part. The content of specific compounds, used as analytical or active markers, should be determined too.…”

Section: Further Researchmentioning

confidence: 99%

Plant-Derived Nutraceuticals and Immune System Modulation: An Evidence-Based Overview

2020

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Immunomodulators are agents able to affect the immune system, by boosting the immune defences to improve the body reaction against infectious or exogenous injuries, or suppressing the abnormal immune response occurring in immune disorders. Moreover, immunoadjuvants can support immune system acting on nonimmune targets, thus improving the immune response. The modulation of inflammatory pathways and microbiome can also contribute to control the immune function. Some plant-based nutraceuticals have been studied as possible immunomodulating agents due to their multiple and pleiotropic effects. Being usually more tolerable than pharmacological treatments, their adjuvant contribution is approached as a desirable nutraceutical strategy. In the present review, the up to date knowledge about the immunomodulating properties of polysaccharides, fatty acids and labdane diterpenes have been analyzed, in order to give scientific basic and clinical evidence to support their practical use. Since promising evidence in preclinical studies, limited and sometimes confusing results have been highlighted in clinical trials, likely due to low methodological quality and lacking standardization. More investigations of high quality and specificity are required to describe in depth the usefulness of these plant-derived nutraceuticals in the immune system modulation, for health promoting and disease preventing purposes.

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A practical guide for transparent reporting of research on natural products in the British Journal of Pharmacology: Reproducibility of natural product research

Cited by 185 publications

References 58 publications

The common diabetes drug metformin can diminish the action of citral against Rhabdomyosarcoma cells in vitro

The common diabetes drug metformin can diminish the action of citral against Rhabdomyosarcoma cells in vitro

Chemopreventive Potential of Caryophyllane Sesquiterpenes: An Overview of Preliminary Evidence

Plant-Derived Nutraceuticals and Immune System Modulation: An Evidence-Based Overview

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