Nano artificial periosteum PLGA/MgO/Quercetin accelerates repair of bone defects through promoting osteogenic − angiogenic coupling effect via Wnt/ β-catenin pathway

He, Xi; Liu, Wenbin; Liu, Yanling; Zhang, Kai; Sun, Yan; Lei, Pengfei; Hu, Yihe

doi:10.1016/j.mtbio.2022.100348

Cited by 15 publications

(25 citation statements)

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“…Gelatin, as a protein-based polymer, is a collagen partially degraded peptide containing an arginine-glycine-aspartate sequence, which can interact directly with cell surface integrins to promote cell adhesion [ [36] , [37] , [38] ]. It is more attractive as a precursor for hydrogels preparation due to its processability, superior water solubility, and lower immunogenicity compared to collagen [ [39] , [40] , [41] ].…”

Section: Discussionmentioning

confidence: 99%

Human urine-derived stem cell exosomes delivered via injectable GelMA templated hydrogel accelerate bone regeneration

Lü

Zeng

Liu

et al. 2023

Materials Today Bio

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Section: Discussionmentioning

confidence: 99%

Human urine-derived stem cell exosomes delivered via injectable GelMA templated hydrogel accelerate bone regeneration

Lü

Zeng

Liu

et al. 2023

Materials Today Bio

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“…BMSC cells were isolated from rats (60-80 g) femur and tibia as described before. 17 BMSC was sub-cultured at 90% confluency and passage 2-3 BMSC were used for experiments. For osteogenic differentiation, cells were cultured with osteogenic media (MUXMT-90021, Cyagen, Guangzhou, China) for 1-14 days.…”

Section: Cell Culturementioning

confidence: 99%

Functional β‐TCP/MnO₂/PCL artificial periosteum promoting osteogenic differentiation of BMSCs by reducing locally reactive oxygen species level

Feng

Huang

Liu

et al. 2023

J Biomedical Materials Res

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Segmental bone defects caused by trauma, tumor resection or congenital malformations are often reconstructed with autologous, allogeneic bone grafts or artificial bone materials, of which, about 5% ~ 10% will have delayed healing or even nonunion of fractures. The loss of periosteum and excessive accumulation of ROS in fracture site leads to the aging of osteoblasts and the decline of their proliferation and differentiation, thus affecting the fracture healing process. In this study, we prepared a functional modified artificial periosteum β‐TCP/MnO2/PCL(β‐TMP) by electrospinning with a function of catalyzing decomposition of H2O2. We examined the surface morphology of β‐TMP, the concentration of Ca, P and Mn of β‐TMP, as well as the diameter distribution range of nanofibers on β‐TMP. Through X‐ray diffraction patterns and Fourier transform infrared spectra, β‐TMP was characterized and its hydrophilicity was tested. The release of Mn2+ and Ca2+ of 0.1 and 0.05% β‐TMP in different pH values (7.4 and 5.5) determined by ICP. We also identified that β‐TMP could reduce the level of ROS in cells by lowering the level of H2O2. 0%, 0.05% and 0.1% β‐TMP displayed good cell compatibility, cell adhesion and cellular morphology in the condition with or without H2O2. 0.5% β‐TMP showed compromised cell compatibility in normal condition, however, the compromised phenotypes could be partially rescued in the present of H2O2. Compared with 0%, 0.05% and 0.1% β‐TMP displayed higher osteoblastic differentiation with or without H2O2 in BMSCs as well as in MG‐63. In sum, β‐TMP helped osteogenesis and promoted repair of bone defects.

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“… 2 , 3 , 4 In vitro and in vivo studies have shown that a plant-derived polyphenol quercetin has a wide range of biological activities, including anticarcinogenic, anti-inflammatory and antiviral activity, as well as reducing lipid peroxidation, platelet aggregation and capillary permeability. 4 , 5 , 6 , 7 , 8 , 9 …”

Section: Introductionmentioning

confidence: 99%

“… 5 Recent studies show that it has positive effects on osteoblast and osteoclast activities. 1 , 4 , 5 , 6 , 7 …”

Section: Introductionmentioning

confidence: 99%

Investigation of the effects of quercetin and xenograft on the healing of bone defects: An experimental study

Durmaz¹,

Gunes²,

Koparal³

et al. 2023

Journal of Oral Biology and Craniofacial Research

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Nano artificial periosteum PLGA/MgO/Quercetin accelerates repair of bone defects through promoting osteogenic − angiogenic coupling effect via Wnt/ β-catenin pathway

Cited by 15 publications

References 50 publications

Human urine-derived stem cell exosomes delivered via injectable GelMA templated hydrogel accelerate bone regeneration

Human urine-derived stem cell exosomes delivered via injectable GelMA templated hydrogel accelerate bone regeneration

Functional β‐TCP/MnO₂/PCL artificial periosteum promoting osteogenic differentiation of BMSCs by reducing locally reactive oxygen species level

Investigation of the effects of quercetin and xenograft on the healing of bone defects: An experimental study

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Nano artificial periosteum PLGA/MgO/Quercetin accelerates repair of bone defects through promoting osteogenic − angiogenic coupling effect via Wnt/ β-catenin pathway

Cited by 15 publications

References 50 publications

Human urine-derived stem cell exosomes delivered via injectable GelMA templated hydrogel accelerate bone regeneration

Human urine-derived stem cell exosomes delivered via injectable GelMA templated hydrogel accelerate bone regeneration

Functional β‐TCP/MnO2/PCL artificial periosteum promoting osteogenic differentiation of BMSCs by reducing locally reactive oxygen species level

Investigation of the effects of quercetin and xenograft on the healing of bone defects: An experimental study

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Functional β‐TCP/MnO₂/PCL artificial periosteum promoting osteogenic differentiation of BMSCs by reducing locally reactive oxygen species level