Nail psoriasis: a combined treatment with 8% clobetasol nail lacquer and tacalcitol ointment

Regaña, Manuel Sánchez; Balbás, Gemma Márquez; Millet, Pablo Umbert

doi:10.1111/j.1468-3083.2008.02679.x

Cited by 39 publications

(23 citation statements)

References 22 publications

(36 reference statements)

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“…Combined treatment with 8% clobetasol-17-propionate in lacquer applied at the weekend and tacalcitol ointment under occlusion on weekdays for 6 months showed a good and quick response; with 78% improvement in the modified target NAPSI score at the end of therapy along with reduction in nail pain. [71]…”

Section: Treatment Of Nail Psoriasismentioning

confidence: 99%

Nail psoriasis: The journey so far

Dogra

Arora

2014

Indian J Dermatol

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Nail involvement is an extremely common feature of psoriasis and affects approximately 10-78% of psoriasis patients with 5-10% of patients having isolated nail psoriasis. However, it is often an overlooked feature in the management of nail psoriasis, despite the significant burden it places on the patients as a result of functional impairment of manual dexterity, pain, and psychological stress. Affected nail plates often thicken and crumble, and because they are very visible, patients tend to avoid normal day-to-day activities and social interactions. Importantly, 70-80% of patients with psoriatic arthritis have nail psoriasis. In this overview, we review the clinical manifestations of psoriasis affecting the nails, the common differential diagnosis of nail psoriasis, Nail Psoriasis Severity Index and the various diagnostic aids for diagnosing nail psoriasis especially, the cases with isolated nail involvement. We have also discussed the available treatment options, including the topical, physical, systemic, and biological modalities, in great detail in order to equip the present day dermatologist in dealing with a big clinical challenge, that is, management of nail psoriasis.

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Section: Treatment Of Nail Psoriasismentioning

confidence: 99%

Nail psoriasis: The journey so far

Dogra

Arora

2014

Indian J Dermatol

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“…Vitamin D 3 analogues of calcipotriol, calcitriol, and tacalcitol have been used in the treatment of nail psoriasis by inhibiting keratinocyte growth and differentiation and suppressing T-cell activity and cytokine production [1, 7, 21, 33]. In a double-blind study involving 58 patients with nail bed psoriasis, topical application of calcipotriol ointment twice daily was found to be as effective as twice daily application of betamethasone dipropionate in reducing subungual hyperkeratosis after 3–9 months [30].…”

Section: Topical Therapymentioning

confidence: 99%

“…Rigopoulos et al [26] demonstrated that the combined treatment with calcipotriol cream (once daily, 5 days a week) and clobetasol propionate cream (once daily, 2 days a week) for 6 months resulted in a 72% reduction at subungual hyperkeratosis. The synergistic effect of topical vitamin D 3 , which mainly affects the nail bed, togetherwith topical corticosteroid that is more effective on nail matrix, may provide safer and better treatment for nail psoriasis [20, 21, 30]. …”

Section: Topical Therapymentioning

confidence: 99%

Treatment of Nail Psoriasis: Common Concepts and New Trends

Oram

Akkaya

2013

Dermatology Research and Practice

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The lifetime incidence of nail involvement in psoriatic patients is estimated to be 80–90%, and the nails can be affected in 10% to 55% of psoriatic patients. Psoriasis may also solely involve the nails, without any other skin findings, in which the treatment can be more challenging. Nail psoriasis may lead to considerable impairment in quality of life due to aesthetic concerns and more importantly limitations in daily activities resulting from the associated pain, which may be overlooked by the physicians. Several topical and systemic treatment modalities, as well as radiation and light systems, have been used in the treatment of nail psoriasis. In the last decade, the introduction of biologic agents and the utilization of laser systems have brought a new insight into the treatment of nail psoriasis. This paper focuses on the recent advances, as well as the conventional methods, in treating nail psoriasis in adults and children, in reference to an extensive literature search.

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“…[62,63] Pulsed dye Laser (PDL) has been used to treat psoriatic plaques, and recently, PDL has been shown to improve nail psoriasis as well. [64] Chronic paronychia is a common problem among the females which is multifactorial in origin.…”

Section: New In Onychomycosis Treatmentmentioning

confidence: 99%